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    Also known as: 70356-09-1, Parsol 1789, Butyl methoxydibenzoylmethane, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, Escalol 517, Eusolex 9020
    Molecular Formula
    C20H22O3
    Molecular Weight
    310.4  g/mol
    InChI Key
    XNEFYCZVKIDDMS-UHFFFAOYSA-N
    FDA UNII
    G63QQF2NOX
    Avobenzona
    Avobenzone is a sunscreen blocker. Avobenzone is a topical, broad range UV protector and blocks UVA I, UVA II, and UVB wavelengths, thereby limiting the impact of UV rays on skin. (NCI05)
    1 2D Structure

    Avobenzona

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione
    2.1.2 InChI
    InChI=1S/C20H22O3/c1-20(2,3)16-9-5-14(6-10-16)18(21)13-19(22)15-7-11-17(23-4)12-8-15/h5-12H,13H2,1-4H3
    2.1.3 InChI Key
    XNEFYCZVKIDDMS-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C)(C)C1=CC=C(C=C1)C(=O)CC(=O)C2=CC=C(C=C2)OC
    2.2 Other Identifiers
    2.2.1 UNII
    G63QQF2NOX
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4-tert-butyl-4'-methoxydibenzoylmethane

    2. Bmdbm Cpd

    3. Butyl-methoxydibenzoylmethane

    4. Parsol 1789

    5. Parsol-1789

    2.3.2 Depositor-Supplied Synonyms

    1. 70356-09-1

    2. Parsol 1789

    3. Butyl Methoxydibenzoylmethane

    4. 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione

    5. Escalol 517

    6. Eusolex 9020

    7. 4-tert-butyl-4'-methoxy-dibenzoylmethane

    8. Neoheliopan 357

    9. 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione

    10. 1-(4-(tert-butyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione

    11. 1,3-propanedione, 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-

    12. G63qqf2nox

    13. Nsc-758680

    14. 1-(p-tert-butylphenyl)-3-(p-methoxyphenyl)-1,3-propanedione

    15. 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione

    16. Ncgc00095112-01

    17. 1,3-propanedione, 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)-

    18. Dsstox_cid_24829

    19. Dsstox_rid_80510

    20. Dsstox_gsid_44829

    21. 87075-14-7

    22. Avobenzona

    23. Avobenzonum

    24. Avobenzonum [inn-latin]

    25. 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-1,3-propanedione

    26. Avobenzona [inn-spanish]

    27. Parsol A

    28. Smr001562107

    29. Cas-70356-09-1

    30. Hsdb 7423

    31. Einecs 274-581-6

    32. Unii-g63qqf2nox

    33. 4-tert-butyl-4'-methoxydibenzoylmethane

    34. Avobenzone [usan:usp:inn]

    35. 4-methoxy-4'-tert-butyldibenzoylmethane

    36. Spectrum_001715

    37. Bf2avb

    38. Avobenzone [mi]

    39. Specplus_000764

    40. Avobenzone (usp/inn)

    41. Avobenzone [inn]

    42. Spectrum2_001663

    43. Spectrum3_000990

    44. Spectrum4_001116

    45. Spectrum5_001358

    46. Avobenzone [hsdb]

    47. Avobenzone [usan]

    48. Avobenzone(parsol 1789)

    49. Ec 274-581-6

    50. Avobenzone [mart.]

    51. Avobenzone [usp-rs]

    52. Avobenzone [who-dd]

    53. Avobenzone (parsol 1789)

    54. Schembl15650

    55. Bspbio_002659

    56. Kbiogr_001592

    57. Kbioss_002195

    58. Zinc973

    59. Mls002695918

    60. Mls006010050

    61. Bidd:er0196

    62. Divk1c_006860

    63. Spectrum1504190

    64. Spbio_001845

    65. Avobenzone, Analytical Standard

    66. Avobenzone [orange Book]

    67. Chembl1200522

    68. Dtxsid9044829

    69. Kbio1_001804

    70. Kbio2_002195

    71. Kbio2_004763

    72. Kbio2_007331

    73. Kbio3_001879

    74. Avobenzone [usp Impurity]

    75. Chebi:134751

    76. Avobenzone [usp Monograph]

    77. Hms1922f17

    78. Hms2093c04

    79. Hms3655c22

    80. Hms3715f14

    81. Pharmakon1600-01504190

    82. Hy-b0316

    83. Tox21_111427

    84. Tox21_202796

    85. Ccg-39080

    86. Mfcd00210252

    87. Nsc758680

    88. S1904

    89. 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedi- One

    90. 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione

    91. Akos015838120

    92. Tox21_111427_1

    93. Ac-1682

    94. Db09495

    95. Nsc 758680

    96. Anthelios Sx Component Avobenzone

    97. Ncgc00095112-02

    98. Ncgc00095112-03

    99. Ncgc00095112-04

    100. Ncgc00095112-05

    101. Ncgc00260342-01

    102. Rac-erythro Methylphenidate Hydrochloride

    103. 23644-60-2

    104. As-12797

    105. Capital Soleil Component Avobenzone

    106. Shade Uvaguard Component Avobenzone

    107. Parsol 1789 100 Microg/ml In Methanol

    108. Sbi-0052777.p002

    109. Avobenzone Component Of Anthelios Sx

    110. Butyl Methoxydibenzoylmethane [inci]

    111. Avobenzone Component Of Capital Soleil

    112. Avobenzone Component Of Shade Uvaguard

    113. B3382

    114. Ft-0623334

    115. Sw219665-1

    116. Parsol 1789 100 Microg/ml In Acetonitrile

    117. D03015

    118. Ab00053273_04

    119. Ab00053273_05

    120. A836855

    121. Sr-05000001974

    122. Q-200661

    123. Q2775914

    124. Sr-05000001974-1

    125. 1-(4-methoxyphenyl)-3-(4-tert-butylphenyl)propane-1,3-dione

    126. 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-propane-1,3-dione

    127. 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propan-1,3-dione

    128. Avobenzone, United States Pharmacopeia (usp) Reference Standard

    129. Avobenzone, Pharmaceutical Secondary Standard; Certified Reference Material

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 310.4 g/mol
    Molecular Formula C20H22O3
    XLogP34.8
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count6
    Exact Mass310.15689456 g/mol
    Monoisotopic Mass310.15689456 g/mol
    Topological Polar Surface Area43.4 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity405
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Daily use of a sunscreen with a high SPF (greater than 15) on usually exposed skin is recommended for residents of areas of high ... /solar radiation/ who work outdoors or ... /enjoy/ regular outdoor recreation. Daily use of a sunscreen can reduce the cumulative ... /solar/ exposure that causes actinic keratoses and squamous-cell carcinoma.

    IARC Working Group on the Evaluation of Cancer-Preventive Agents (2001) Sunscreens (IARC Handbooks of Cancer Prevention, Vol. 5), Lyon, IARC; Unit of Chemoprevention: Cancer-Preventive Effects of Sunscreens.

    Sunscreen agents are indicated for the prevention of sunburn. In addition to limiting the skin's exposure to the sun, using sunscreen agents regularly when in the sun may help reduce long-term sun damage such as premature aging of the skin and skin cancer. /Sunscreen agents, topical; Included in US product labeling/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.

    Sunscreen preparations should be applied uniformly and generously to all exposed skin surfaces, including lips, before exposure to UVB radiation. Two applications of the sunscreen may be needed for maximum protection. PABA-containing sunscreens are most effective when applied 1-2 hours before exposure to sunlight. Sunscreen products that are not water resistant should be reapplied after swimming, towel-drying, or profuse sweating and, because most sunscreens are easily removed from the skin, reapplication every 1-2 hours or according to the manufacturer's directions usually is required to provide adequate protection from UVB light. /Sunscreens/

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013

    4.2 Drug Warning

    The manufacturers of sunscreen preparations with propellants warn that concentrating and subsequently inhaling the fumes from these preparations may be harmful or fatal. /Propellants/

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013

    Because the absorptive characteristics of skin of children younger than 6 months of age may differ from those of adults and because the immaturity of metabolic and excretory pathways of these children may limit their ability to eliminate any percutaneously absorbed sunscreen agent, sunscreen products should be used in children younger than 6 months of age only as directed by a clinician. It is possible that the characteristics of geriatric skin also differ from those of skin in younger adults, but these characteristics and the need for special considerations regarding use of sunscreen preparations in this age group are poorly understood. /Sunscreens/

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013

    Little information is available regarding the safety of chronic sunscreen usage, but commercially available physical and chemical sunscreens appear to have a low incidence of adverse effects. Derivatives of PABA, benzophenone, cinnamic acid, and salicylate and 2-phenylbenzimidazole-5-sulfonic acid have caused skin irritation including burning, stinging, pruritus, and erythema on rare occasions. /Sunscreens/

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013

    Sunscreens should not be used as a means of extending the duration of solar exposure, such as prolonging sunbathing, and should not be used as a substitute for clothing on usually unexposed sites, such as the trunk and buttocks. /Sunscreens/

    IARC Working Group on the Evaluation of Cancer-Preventive Agents (2001) Sunscreens (IARC Handbooks of Cancer Prevention, Vol. 5), Lyon, IARC; Unit of Chemoprevention: Cancer-Preventive Effects of Sunscreens.

    For more Drug Warnings (Complete) data for AVOBENZONE (11 total), please visit the HSDB record page.

    4.3 Drug Indication

    Sun protection factor, added in the sunscreen products for its wide spectrum ultraviolet absorption properties.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Sunscreening Agents

    Chemical or physical agents that protect the skin from sunburn and erythema by absorbing or blocking ultraviolet radiation. (See all compounds classified as Sunscreening Agents.)

    5.2 Absorption, Distribution and Excretion

    Solvents used in sunscreen products affect the stability and binding of the drug to the skin; in general, alcoholic solvents allow for the most rapid and deepest epidermal penetration of sunscreens. It appears that sunscreen agents are absorbed by the intact epidermis to varying degrees. /Sunscreens/

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013

    5.3 Mechanism of Action

    It blocks UVA I, UVA II, and UVB wavelengths, thereby limiting the impact of UV rays on skin. Diminish the penetration of ultraviolet (UV) light through the epidermis by absorbing UV radiation within a specific wavelength range. The amount and wavelength of UV radiation absorbed are affected by the molecular structure of the sunscreen agent.

    Diminish the penetration of ultraviolet (UV) light through the epidermis by absorbing UV radiation within a specific wavelength range. The amount and wavelength of UV radiation absorbed are affected by the molecular structure of the sunscreen agent. /Sunscreen agents, topical/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.

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COSMOS CHEMICALS CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"GIVAUDAN (INDIA) PRIVATE LIMITED","customerCountry":"INDIA","quantity":"180.00","actualQuantity":"180","unit":"KGS","unitRateFc":"15","totalValueFC":"2728.8","currency":"USD","unitRateINR":"1267.2","date":"08-Jul-2024","totalValueINR":"228101.98","totalValueInUsd":"2728.8","indian_port":"Madras Sea","hs_no":"29145000","bill_no":"4382035","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"10F,C1 TOWER , JIULONGHUINTERNATIONAL CORPORATIVEHEADQUARTERS, NO 19, JIANGNING CHINA","customerAddress":"PLOT NO.26,2ND CROSS,JIGANI"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728066600,"product":"AVOBENZONE MCS-03 (SUNOBEL AVB) (ORGANIC CHEMICALS FOR MFG OF INDUSTRIAL FRAGRANCE COMPOUNDING ONLY)","address":"PLOT NO.26,2ND CROSS,JIGANI","city":"BANGALORE","supplier":"NANJING COSMOS CHEMICALS CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"GIVAUDAN (INDIA) PRIVATE LIMITED","customerCountry":"INDIA","quantity":"180.00","actualQuantity":"180","unit":"KGS","unitRateFc":"14.9","totalValueFC":"2709.3","currency":"USD","unitRateINR":"1264.8","date":"05-Oct-2024","totalValueINR":"227655.1","totalValueInUsd":"2709.3","indian_port":"Madras Sea","hs_no":"29145000","bill_no":"5959036","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"10F,C1 TOWER , JIULONGHU INTERNATIONAL CORPORATIVE HEADQUARTERS, NO 19, JIANGNING CHINA","customerAddress":"PLOT NO.26,2ND CROSS,JIGANI"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734633000,"product":"AVOBENZONE AVOBENZONE","address":"FIRST FLOOR, ELEGANCE TOWER,","city":"COMMERCIAL CENTRE, JASOLA NEW 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,MAHARASHTRA","supplier":"CATALYNT SOLUTIONS INC","supplierCountry":"UNITED STATES","foreign_port":"HOUSTON","customer":"CHEMSPEC CHEMICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"8475.00","actualQuantity":"8475","unit":"KGS","unitRateFc":"13.2","totalValueFC":"122980.4","currency":"USD","unitRateINR":"1233","date":"21-Dec-2024","totalValueINR":"10449523.37","totalValueInUsd":"122980.4","indian_port":"JNPT","hs_no":"29145000","bill_no":"7372109","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"HOUSTON","supplierAddress":"22817 102ND PLACE WEST EDMONDS, WA 98020 USA SDNF UNITED STATES","customerAddress":"9 WALLACE ST FORT"}]
    12-Jan-2022
    22-Apr-2025
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    ABOUT THIS PAGE

    Looking for 70356-09-1 / Avobenzona API manufacturers, exporters & distributors?

    Avobenzona manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Avobenzona API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Avobenzona manufacturer or Avobenzona supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Avobenzona manufacturer or Avobenzona supplier.

    PharmaCompass also assists you with knowing the Avobenzona API Price utilized in the formulation of products. Avobenzona API Price is not always fixed or binding as the Avobenzona Price is obtained through a variety of data sources. The Avobenzona Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Avobenzona

    Synonyms

    70356-09-1, Parsol 1789, Butyl methoxydibenzoylmethane, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, Escalol 517, Eusolex 9020

    Cas Number

    70356-09-1

    Unique Ingredient Identifier (UNII)

    G63QQF2NOX

    About Avobenzona

    Avobenzone is a sunscreen blocker. Avobenzone is a topical, broad range UV protector and blocks UVA I, UVA II, and UVB wavelengths, thereby limiting the impact of UV rays on skin. (NCI05)

    PARSOL 1789 (AVOBENZONE) Manufacturers

    A PARSOL 1789 (AVOBENZONE) manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of PARSOL 1789 (AVOBENZONE), including repackagers and relabelers. The FDA regulates PARSOL 1789 (AVOBENZONE) manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. PARSOL 1789 (AVOBENZONE) API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of PARSOL 1789 (AVOBENZONE) manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    PARSOL 1789 (AVOBENZONE) Suppliers

    A PARSOL 1789 (AVOBENZONE) supplier is an individual or a company that provides PARSOL 1789 (AVOBENZONE) active pharmaceutical ingredient (API) or PARSOL 1789 (AVOBENZONE) finished formulations upon request. The PARSOL 1789 (AVOBENZONE) suppliers may include PARSOL 1789 (AVOBENZONE) API manufacturers, exporters, distributors and traders.

    click here to find a list of PARSOL 1789 (AVOBENZONE) suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    PARSOL 1789 (AVOBENZONE) USDMF

    A PARSOL 1789 (AVOBENZONE) DMF (Drug Master File) is a document detailing the whole manufacturing process of PARSOL 1789 (AVOBENZONE) active pharmaceutical ingredient (API) in detail. Different forms of PARSOL 1789 (AVOBENZONE) DMFs exist exist since differing nations have different regulations, such as PARSOL 1789 (AVOBENZONE) USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A PARSOL 1789 (AVOBENZONE) DMF submitted to regulatory agencies in the US is known as a USDMF. PARSOL 1789 (AVOBENZONE) USDMF includes data on PARSOL 1789 (AVOBENZONE)'s chemical properties, information on the facilities and procedures used, and details about packaging and storage. The PARSOL 1789 (AVOBENZONE) USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of PARSOL 1789 (AVOBENZONE) suppliers with USDMF on PharmaCompass.

    PARSOL 1789 (AVOBENZONE) NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing PARSOL 1789 (AVOBENZONE) as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for PARSOL 1789 (AVOBENZONE) API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture PARSOL 1789 (AVOBENZONE) as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain PARSOL 1789 (AVOBENZONE) and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a PARSOL 1789 (AVOBENZONE) NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of PARSOL 1789 (AVOBENZONE) suppliers with NDC on PharmaCompass.

    PARSOL 1789 (AVOBENZONE) GMP

    PARSOL 1789 (AVOBENZONE) Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of PARSOL 1789 (AVOBENZONE) GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right PARSOL 1789 (AVOBENZONE) GMP manufacturer or PARSOL 1789 (AVOBENZONE) GMP API supplier for your needs.

    PARSOL 1789 (AVOBENZONE) CoA

    A PARSOL 1789 (AVOBENZONE) CoA (Certificate of Analysis) is a formal document that attests to PARSOL 1789 (AVOBENZONE)'s compliance with PARSOL 1789 (AVOBENZONE) specifications and serves as a tool for batch-level quality control.

    PARSOL 1789 (AVOBENZONE) CoA mostly includes findings from lab analyses of a specific batch. For each PARSOL 1789 (AVOBENZONE) CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    PARSOL 1789 (AVOBENZONE) may be tested according to a variety of international standards, such as European Pharmacopoeia (PARSOL 1789 (AVOBENZONE) EP), PARSOL 1789 (AVOBENZONE) JP (Japanese Pharmacopeia) and the US Pharmacopoeia (PARSOL 1789 (AVOBENZONE) USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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