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Also known as: 1426698-88-5, Incb050465, Parsaclisib [inn], Parsaclisib [usan], Incb-050465, Os7097575k

Molecular Formula

C₂₀H₂₂ClFN₆O₂

Molecular Weight

432.9 g/mol

InChI Key

ZQPDJCIXJHUERQ-QWRGUYRKSA-N

FDA UNII

OS7097575K

Parsaclisib is an inhibitor of the delta isoform of phosphoinositide-3 kinase (PI3K) with potential antineoplastic activity. Parsaclisib inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic disease and cell lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.

1 2D Structure

Parsaclisib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4R)-4-[3-[(1S)-1-(4-amino-3-methylpyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl]pyrrolidin-2-one

2.1.2 InChI

InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11-/m0/s1

2.1.3 InChI Key

ZQPDJCIXJHUERQ-QWRGUYRKSA-N

2.1.4 Canonical SMILES

CCOC1=C(C(=C(C=C1C(C)N2C3=NC=NC(=C3C(=N2)C)N)Cl)F)C4CC(=O)NC4

2.1.5 Isomeric SMILES

CCOC1=C(C(=C(C=C1[C@H](C)N2C3=NC=NC(=C3C(=N2)C)N)Cl)F)[C@H]4CC(=O)NC4

2.2 Other Identifiers

2.2.1 UNII

OS7097575K

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (4r)-4-(3-((1s)-1-(4-amino-3-methyl-1h-pyrazolo(3,4-d)pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one

2. 2-pyrrolidinone, 4-(3-((1s)-1-(4-amino-3-methyl-1h-pyrazolo(3,4-d)pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)-, (4r)-

3. Incb050465

2.3.2 Depositor-Supplied Synonyms

1. 1426698-88-5

2. Incb050465

3. Parsaclisib [inn]

4. Parsaclisib [usan]

5. Incb-050465

6. Os7097575k

7. (4r)-4-[3-[(1s)-1-(4-amino-3-methylpyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl]pyrrolidin-2-one

8. (4r)-4-(3-((1s)-1-(4-amino-3-methyl-1h-pyrazolo(3,4-d)pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one

9. 2-pyrrolidinone, 4-(3-((1s)-1-(4-amino-3-methyl-1h-pyrazolo(3,4-d)pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)-, (4r)-

10. Parsaclisib (usan/inn)

11. Parsaclisib [usan:inn]

12. Incb050465 Free Base

13. Parsaclisib [who-dd]

14. Incb-050465 Free Base

15. Parsaclisib (incb050465)

16. Chembl4297615

17. Schembl14736228

18. Unii-os7097575k

19. Bdbm272573

20. Ex-a2638

21. Who 10589

22. Db14867

23. Ac-36916

24. Us10065963, 32c

25. Hy-109068

26. Cs-0033435

27. D11437

28. (r)-4-(3-((s)-1-(4-amino-3-methyl-1h-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one

2.4 Create Date

2015-02-02

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₂ClFN₆O₂
Molecular Weight	432.9 g/mol
XLogP3	2.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	432.1476798 g/mol
Monoisotopic Mass	432.1476798 g/mol
Topological Polar Surface Area	108 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	632
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1