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Pargyline

Synopsis, Chemistry

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Also known as: 306-07-0, Pargyline hcl, Eutonyl, N-methyl-n-propargylbenzylamine hydrochloride, Eutonyl-ten, N-methyl-n-2-propynylbenzylamine hydrochloride

Molecular Formula

C₁₁H₁₄ClN

Molecular Weight

195.69 g/mol

InChI Key

BCXCABRDBBWWGY-UHFFFAOYSA-N

FDA UNII

W70V6I2OMY

A monoamine oxidase inhibitor with antihypertensive properties.

1 2D Structure

Pargyline

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-benzyl-N-methylprop-2-yn-1-amine;hydrochloride

2.1.2 InChI

InChI=1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H

2.1.3 InChI Key

BCXCABRDBBWWGY-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN(CC#C)CC1=CC=CC=C1.Cl

2.2 Other Identifiers

2.2.1 UNII

W70V6I2OMY

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Hydrochloride, Pargyline

2. Pargyline

2.3.2 Depositor-Supplied Synonyms

1. 306-07-0

2. Pargyline Hcl

3. Eutonyl

4. N-methyl-n-propargylbenzylamine Hydrochloride

5. Eutonyl-ten

6. N-methyl-n-2-propynylbenzylamine Hydrochloride

7. N-benzyl-n-methylprop-2-yn-1-amine Hydrochloride

8. Pargyline Chloride

9. Pargyline, Hcl

10. Pargyline (hydrochloride)

11. Usaf A-19120

12. Benzylmethylpropynylamine Hydrochloride

13. Methylbenzylpropynylamine Hydrochloride

14. Mo-911

15. Benzenemethanamine, N-methyl-n-2-propynyl-, Hydrochloride

16. Pargyline Hydrochloride [usan]

17. Mfcd00012492

18. N-benzyl-n-methyl-2-propynylamine Hydrochloride

19. Nsc-43798

20. A-19120

21. N-benzyl-n-methylprop-2-yn-1-amine;hydrochloride

22. W70v6i2omy

23. Mls000028460

24. Benzylamine, N-methyl-n-2-propynyl-, Hydrochloride

25. Smr000058367

26. Dsstox_cid_24647

27. Dsstox_rid_80375

28. Dsstox_gsid_44647

29. Pargyline Hydrochloride (usan)

30. Nsc43798

31. Pargylamine Hydrochloride

32. Sr-01000003035

33. Ncgc00015841-02

34. Cas-306-07-0

35. Einecs 206-175-1

36. Nsc 43798

37. Unii-w70v6i2omy

38. Ai3-62178

39. N-methyl-n-(2-propynyl)benzylamine Hydrochloride

40. N-methyl-n-propargylbenzylamine Hcl

41. Prestwick_377

42. 2-propynylamine, N-benzyl-n-methyl-, Hydrochloride

43. Eutonyl (tn)

44. Pargyline Hydrochloride [usan:usp]

45. Opera_id_404

46. N-methyl-n-propargylbenzylaminehydrochloride

47. Mls001076511

48. Pargyline Hydrochloride, 99%

49. Schembl121111

50. 2-propynylamine, Hydrochloride

51. Chembl1200425

52. Dtxsid1044647

53. Hms1568f07

54. Pharmakon1600-01500462

55. Amy20608

56. Bcp21320

57. Hy-a0091

58. Pargyline Hydrochloride [mi]

59. Tox21_110241

60. Tox21_302678

61. Tox21_501022

62. Ccg-40239

63. Nsc757264

64. S3690

65. Akos015950558

66. Tox21_110241_1

67. Lp01022

68. Nsc-757264

69. Pargyline Hydrochloride [mart.]

70. Pargyline Hydrochloride [vandf]

71. Wln: 1uu2n1 & 1r & Gh

72. Pargyline Hydrochloride [who-dd]

73. Ncgc00015841-11

74. Ncgc00094313-01

75. Ncgc00094313-02

76. Ncgc00094313-03

77. Ncgc00256654-01

78. Ncgc00261707-01

79. Ac-18917

80. As-16929

81. Sy005867

82. Db-047811

83. Eu-0101022

84. Ft-0631924

85. Pargyline Hydrochloride [orange Book]

86. Bim-0050995.0001

87. D02564

88. Eutron Component Pargyline Hydrochloride

89. P 8013

90. A820454

91. A935225

92. Pargyline Hydrochloride Component Of Eutron

93. N-benzyl-n-methylprop-2-yn-1-amine;hydron;chloride

94. Sr-01000003035-2

95. Sr-01000003035-7

96. Q27292421

97. Sr-01000003035-11

98. N-methyl-n-(phenylmethyl)-2-propyn-1-amine Hydrochloride

99. N-methyl-n-(phenylmethyl)prop-2-yn-1-amine Hydrochloride

100. 4-(3-methylpyrazin-2-yl)-6-methyl-pyrimidin-2-amine

101. Benzenemethanamine, N-methyl-n-2-propyn-1-yl-, Hydrochloride (1:1)

102. Benzenemethanamine,n-methyl-n-2-propyn-1-yl-, Hydrochloride (1:1);

103. Pargyline Hydrochloride, United States Pharmacopeia (usp) Reference Standard

104. N-benzyl-n-methylprop-2-yn-1-amine Hydrochloride; Eutonyl-ten; N-methyl-n-propargylbenzylamine Hydrochloride; Pargyline Hcl

2.4 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	C₁₁H₁₄ClN
Molecular Weight	195.69 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	3
Exact Mass	195.0814771 g/mol
Monoisotopic Mass	195.0814771 g/mol
Topological Polar Surface Area	3.2 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	159
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Monoamine Oxidase Inhibitors

A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414) (See all compounds classified as Monoamine Oxidase Inhibitors.)