Find Palupiprant manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

API REF. PRICE (USD/KG)

$
$ 0

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Regulatory FDF Prices

NA

API/FDF Prices: Book a Demo to
explore the features and consider
upgrading later

MARKET PLACE

0

API

0

FDF

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 1369489-71-3, E7046, E-7046, Er-886046, Palupiprant, Ywy620gu8i
Molecular Formula
C22H18F5N3O4
Molecular Weight
483.4  g/mol
InChI Key
MKLKAQMPKHNQPR-NSHDSACASA-N
FDA UNII
YWY620GU8I

Palupiprant
Palupiprant is an orally bioavailable antagonist of the prostaglandin E2 (PGE2) receptor type 4 (EP4; EP-4), with potential immunomodulating and antineoplastic activities. Upon oral administration, palupiprant selectively targets, binds to and blocks the activity of immunosuppressive tumor-associated myeloid cells (TAMCs) in the microenvironment. This abolishes TAMC-dependent immunosuppression and reduces tumor cell proliferation. The presence of immunosuppressive myeloid cells in certain tumors is associated with a poor prognosis.
1 2D Structure

Palupiprant

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[(1S)-1-[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]pyrazole-4-carbonyl]amino]ethyl]benzoic acid
2.1.2 InChI
InChI=1S/C22H18F5N3O4/c1-11(12-6-8-13(9-7-12)21(32)33)28-19(31)16-17(18(23)24)29-30(2)20(16)34-15-5-3-4-14(10-15)22(25,26)27/h3-11,18H,1-2H3,(H,28,31)(H,32,33)/t11-/m0/s1
2.1.3 InChI Key
MKLKAQMPKHNQPR-NSHDSACASA-N
2.1.4 Canonical SMILES
CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(N(N=C2C(F)F)C)OC3=CC=CC(=C3)C(F)(F)F
2.1.5 Isomeric SMILES
C[C@@H](C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(N(N=C2C(F)F)C)OC3=CC=CC(=C3)C(F)(F)F
2.2 Other Identifiers
2.2.1 UNII
YWY620GU8I
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-((1s)-1-((3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)pyrazole-4-carbonyl)amino)ethyl)benzoic Acid

2. E7046

2.3.2 Depositor-Supplied Synonyms

1. 1369489-71-3

2. E7046

3. E-7046

4. Er-886046

5. Palupiprant

6. Ywy620gu8i

7. (s)-4-(1-(3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1h-pyrazole-4-carboxamido)ethyl)benzoic Acid

8. 4-[(1s)-1-[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]pyrazole-4-carbonyl]amino]ethyl]benzoic Acid

9. 4-[(1s)-1-[[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]-1h-pyrazol-4-yl]carbonyl]amino]ethyl]-benzoic Acid

10. Unii-ywy620gu8i

11. Palupiprant [inn]

12. Schembl881212

13. Chembl3670685

14. Bdbm119448

15. E 7046 [who-dd]

16. Bcp25989

17. Ex-a1726

18. Nsc804040

19. S6649

20. Er 886046 [who-dd]

21. Akos037644995

22. Cs-7559

23. Nsc-804040

24. E7046 Pound Er-886406 Pound(c)

25. Ac-30338

26. As-55893

27. Er 886046

28. Hy-103088

29. E 7046

30. Us8686018, 107

31. Q27294756

32. 4-((1s)-1-(((3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1h-pyrazol-4-yl)carbonyl)amino)ethyl)benzoic Acid

33. 4-[(1s)-1-{[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]pyrazol-4-yl]formamido}ethyl]benzoic Acid

2.4 Create Date
2012-04-23
3 Chemical and Physical Properties
Molecular Weight 483.4 g/mol
Molecular Formula C22H18F5N3O4
XLogP34.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area93.4
Heavy Atom Count34
Formal Charge0
Complexity717
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1369489-71-3 / Palupiprant API manufacturers, exporters & distributors?

Palupiprant manufacturers, exporters & distributors 1

59

PharmaCompass offers a list of Palupiprant API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Palupiprant manufacturer or Palupiprant supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Palupiprant manufacturer or Palupiprant supplier.

PharmaCompass also assists you with knowing the Palupiprant API Price utilized in the formulation of products. Palupiprant API Price is not always fixed or binding as the Palupiprant Price is obtained through a variety of data sources. The Palupiprant Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Palupiprant

Synonyms

1369489-71-3, E7046, E-7046, Er-886046, Ywy620gu8i, (s)-4-(1-(3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1h-pyrazole-4-carboxamido)ethyl)benzoic acid

Cas Number

1369489-71-3

Unique Ingredient Identifier (UNII)

YWY620GU8I

About Palupiprant

Palupiprant is an orally bioavailable antagonist of the prostaglandin E2 (PGE2) receptor type 4 (EP4; EP-4), with potential immunomodulating and antineoplastic activities. Upon oral administration, palupiprant selectively targets, binds to and blocks the activity of immunosuppressive tumor-associated myeloid cells (TAMCs) in the microenvironment. This abolishes TAMC-dependent immunosuppression and reduces tumor cell proliferation. The presence of immunosuppressive myeloid cells in certain tumors is associated with a poor prognosis.

Palupiprant Manufacturers

A Palupiprant manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Palupiprant, including repackagers and relabelers. The FDA regulates Palupiprant manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Palupiprant API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Palupiprant Suppliers

A Palupiprant supplier is an individual or a company that provides Palupiprant active pharmaceutical ingredient (API) or Palupiprant finished formulations upon request. The Palupiprant suppliers may include Palupiprant API manufacturers, exporters, distributors and traders.

Palupiprant GMP

Palupiprant Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Palupiprant GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Palupiprant GMP manufacturer or Palupiprant GMP API supplier for your needs.

Palupiprant CoA

A Palupiprant CoA (Certificate of Analysis) is a formal document that attests to Palupiprant's compliance with Palupiprant specifications and serves as a tool for batch-level quality control.

Palupiprant CoA mostly includes findings from lab analyses of a specific batch. For each Palupiprant CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Palupiprant may be tested according to a variety of international standards, such as European Pharmacopoeia (Palupiprant EP), Palupiprant JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Palupiprant USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty