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Chemistry

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Also known as: 1294000-61-5, Padsevonil [inn], Padsevonil [usan], Ucb0942, Ucb-0942, Ucb1415943-000
Molecular Formula
C14H14ClF5N4O2S
Molecular Weight
432.8  g/mol
InChI Key
DCXFIOLWWRXEQH-SSDOTTSWSA-N
FDA UNII
0R1HN52K0N

Padsevonil
Padsevonil is under investigation in clinical trial NCT03695094 (A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil).
1 2D Structure

Padsevonil

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4R)-4-(2-chloro-2,2-difluoroethyl)-1-[[2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl]pyrrolidin-2-one
2.1.2 InChI
InChI=1S/C14H14ClF5N4O2S/c1-26-6-9-22-24-8(11(14(18,19)20)21-12(24)27-9)5-23-4-7(2-10(23)25)3-13(15,16)17/h7H,2-6H2,1H3/t7-/m1/s1
2.1.3 InChI Key
DCXFIOLWWRXEQH-SSDOTTSWSA-N
2.1.4 Canonical SMILES
COCC1=NN2C(=C(N=C2S1)C(F)(F)F)CN3CC(CC3=O)CC(F)(F)Cl
2.1.5 Isomeric SMILES
COCC1=NN2C(=C(N=C2S1)C(F)(F)F)CN3C[C@H](CC3=O)CC(F)(F)Cl
2.2 Other Identifiers
2.2.1 UNII
0R1HN52K0N
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (4r)-4-(2-chloro-2,2-difluoroethyl)-1-((2-(methoxymethyl)-6-(trifluoromethyl)imidazo(2,1-b)(1,3,4)thiadiazol-5-yl)methyl)-2-pyrrolidinone

2. 2-pyrrolidinone, 4-(2-chloro-2,2-difluoroethyl)-1-((2-(methoxymethyl)-6-(trifluoromethyl)imidazo(2,1-b)-1,3,4-thiadiazol-5-yl)methyl)-, (4r)-

2.3.2 Depositor-Supplied Synonyms

1. 1294000-61-5

2. Padsevonil [inn]

3. Padsevonil [usan]

4. Ucb0942

5. Ucb-0942

6. Ucb1415943-000

7. 0r1hn52k0n

8. Ucb-1415943-000

9. (4r)-4-(2-chloro-2,2-difluoroethyl)-1-((2-(methoxymethyl)-6-(trifluoromethyl)imidazo(2,1-b)(1,3,4)thiadiazol-5-yl)methyl)pyrrolidin-2-one

10. (4r)-4-(2-chloro-2,2-difluoroethyl)-1-[[2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl]pyrrolidin-2-one

11. 2-pyrrolidinone, 4-(2-chloro-2,2-difluoroethyl)-1-((2-(methoxymethyl)-6-(trifluoromethyl)imidazo(2,1-b)-1,3,4-thiadiazol-5-yl)methyl)-, (4r)-

12. Padsevonil [jan]

13. Padsevonil (jan/usan)

14. Padsevonil [who-dd]

15. Unii-0r1hn52k0n

16. Schembl1672843

17. Chembl4297521

18. Ex-a5541

19. Who 10384

20. Db14977

21. Hy-109009

22. Cs-0030507

23. D11842

24. Q27237119

25. (4r)-4-(2-chloro-2,2-difluoroethyl)-1-((2-(methoxymethyl)-6-(trifluoromethyl)imidazo(2,1-b)(1,3,4)thiadiazol-5-yl)methyl)-2-pyrrolidinone

2.4 Create Date
2011-05-23
3 Chemical and Physical Properties
Molecular Weight 432.8 g/mol
Molecular Formula C14H14ClF5N4O2S
XLogP32.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Exact Mass432.0446154 g/mol
Monoisotopic Mass432.0446154 g/mol
Topological Polar Surface Area88 Ų
Heavy Atom Count27
Formal Charge0
Complexity572
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)


ABOUT THIS PAGE

Looking for 1294000-61-5 / Padsevonil API manufacturers, exporters & distributors?

Padsevonil manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Padsevonil API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Padsevonil manufacturer or Padsevonil supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Padsevonil manufacturer or Padsevonil supplier.

PharmaCompass also assists you with knowing the Padsevonil API Price utilized in the formulation of products. Padsevonil API Price is not always fixed or binding as the Padsevonil Price is obtained through a variety of data sources. The Padsevonil Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Padsevonil

Synonyms

1294000-61-5, Padsevonil [inn], Padsevonil [usan], Ucb0942, Ucb-0942, Ucb1415943-000

Cas Number

1294000-61-5

Unique Ingredient Identifier (UNII)

0R1HN52K0N

About Padsevonil

Padsevonil is under investigation in clinical trial NCT03695094 (A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil).

Padsevonil Manufacturers

A Padsevonil manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Padsevonil, including repackagers and relabelers. The FDA regulates Padsevonil manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Padsevonil API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Padsevonil Suppliers

A Padsevonil supplier is an individual or a company that provides Padsevonil active pharmaceutical ingredient (API) or Padsevonil finished formulations upon request. The Padsevonil suppliers may include Padsevonil API manufacturers, exporters, distributors and traders.

Padsevonil GMP

Padsevonil Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Padsevonil GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Padsevonil GMP manufacturer or Padsevonil GMP API supplier for your needs.

Padsevonil CoA

A Padsevonil CoA (Certificate of Analysis) is a formal document that attests to Padsevonil's compliance with Padsevonil specifications and serves as a tool for batch-level quality control.

Padsevonil CoA mostly includes findings from lab analyses of a specific batch. For each Padsevonil CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Padsevonil may be tested according to a variety of international standards, such as European Pharmacopoeia (Padsevonil EP), Padsevonil JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Padsevonil USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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