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Chemistry

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Also known as: Ornithine, 70-26-8, (s)-2,5-diaminopentanoic acid, (s)-ornithine, (s)-2,5-diaminovaleric acid, Ornithine [inn]
Molecular Formula
C5H12N2O2
Molecular Weight
132.16  g/mol
InChI Key
AHLPHDHHMVZTML-BYPYZUCNSA-N
FDA UNII
E524N2IXA3

Ornithine
An amino acid produced in the urea cycle by the splitting off of urea from arginine.
1 2D Structure

Ornithine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2,5-diaminopentanoic acid
2.1.2 InChI
InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1
2.1.3 InChI Key
AHLPHDHHMVZTML-BYPYZUCNSA-N
2.1.4 Canonical SMILES
C(CC(C(=O)O)N)CN
2.1.5 Isomeric SMILES
C(C[C@@H](C(=O)O)N)CN
2.2 Other Identifiers
2.2.1 UNII
E524N2IXA3
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2,5 Diaminopentanoic Acid

2. 2,5-diaminopentanoic Acid

3. Ornithine

4. Ornithine Dihydrochloride, (l)-isomer

5. Ornithine Hydrochloride, (d)-isomer

6. Ornithine Hydrochloride, (dl)-isomer

7. Ornithine Hydrochloride, (l)-isomer

8. Ornithine Monoacetate, (l)-isomer

9. Ornithine Monohydrobromide, (l)-isomer

10. Ornithine Monohydrochloride, (d)-isomer

11. Ornithine Monohydrochloride, (dl)-isomer

12. Ornithine Phosphate (1:1), (l)-isomer

13. Ornithine Sulfate (1:1), (l)-isomer

14. Ornithine, (d)-isomer

15. Ornithine, (dl)-isomer

16. Ornithine, (l)-isomer

2.3.2 Depositor-Supplied Synonyms

1. Ornithine

2. 70-26-8

3. (s)-2,5-diaminopentanoic Acid

4. (s)-ornithine

5. (s)-2,5-diaminovaleric Acid

6. Ornithine [inn]

7. (2s)-2,5-diaminopentanoic Acid

8. L-norvaline, 5-amino-

9. (s)-alpha,delta-diaminovaleric Acid

10. Ornithinum [latin]

11. Ornitina [spanish]

12. Ornithine (van)

13. (+)-s-ornithine

14. (s)-2,5-diaminopentanoate

15. Ornithine, (l)-isomer

16. Pentanoic Acid, 2,5-diamino-, (s)-

17. Ornithine, L-

18. L-ornithine, Hcl

19. Brn 1722298

20. L-(-)-ornithine

21. Chebi:15729

22. Nsc-758894

23. E524n2ixa3

24. Ornithine (inn)

25. Polyornithine

26. Poly-l-ornithine

27. L( )-ornithine

28. 5-amino-l-norvaline

29. Ornithinum

30. Ornitina

31. L-ornithine, Homopolymer

32. Orn

33. L(-)-ornithine

34. Einecs 200-731-7

35. Unii-e524n2ixa3

36. Levo-ornithine

37. 1hqg

38. 1lah

39. 3jdw

40. 25104-12-5

41. L-ornithine (9ci)

42. 5-diaminopentanoic Acid

43. Ornithine [mi]

44. Ornithine [inci]

45. (s)-a,d-diaminovalerate

46. Ornithine, L- (8ci)

47. Bmse000162

48. Ornithine [mart.]

49. Ornithine [who-dd]

50. Schembl8579

51. Gtpl725

52. (s)-a,d-diaminovaleric Acid

53. 4-04-00-02644 (beilstein Handbook Reference)

54. Pentanoic Acid, 2,5-diamino

55. Chembl446143

56. Alpha, Delta-diaminovaleric Acid

57. Dtxsid00883219

58. L-ornithine2,5-diaminovalericacid

59. Pharmakon1600-01504524

60. Hy-b1352

61. Zinc1532530

62. (r,s)-2,5-diamino-pentanoic Acid

63. Bdbm50487430

64. L-ornithine;2,5-diaminovaleric Acid

65. Mfcd00242584

66. Nsc758894

67. S4857

68. Akos006239312

69. Cs-4817

70. Db00129

71. Nsc 758894

72. Smp2_000009

73. Ncgc00263569-01

74. Ac-13803

75. As-80993

76. (s)-2

77. S4653

78. C00077

79. D08302

80. Lysine Acetate Impurity E [ep Impurity]

81. 070o268

82. A866639

83. Q410198

84. W-104562

85. 8ab10027-4d34-488a-9f55-e86692ca2853

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 132.16 g/mol
Molecular Formula C5H12N2O2
XLogP3-4.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass132.089877630 g/mol
Monoisotopic Mass132.089877630 g/mol
Topological Polar Surface Area89.3 Ų
Heavy Atom Count9
Formal Charge0
Complexity95
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Used for nutritional supplementation, also for treating dietary shortage or imbalance. It has been claimed that ornithine improves athletic performance, has anabolic effects, has wound-healing effects, and is immuno-enhancing.


5 Pharmacology and Biochemistry
5.1 Pharmacology

A non-essential and nonprotein amino acid, ornithine is critical for the production of the body's proteins, enzymes and muscle tissue. Ornithine plays a central role in the urea cycle and is important for the disposal of excess nitrogen (ammonia). Ornithine is the starting point for the synthesis of many polyamines such as putrescine and spermine. Ornithine supplements are claimed to enhance the release of growth hormone and to burn excess body fat. Ornithine is necessary for proper immune function and good liver function.


5.2 Absorption, Distribution and Excretion

Absorption

Absorbed from the small intestine via a sodium-dependent active transport process


5.3 Metabolism/Metabolites

Ornithine undergoes extensive metabolism in the liver to L-arginine, polyamines, and proline, and several other metabolites.


5.4 Mechanism of Action

L-Ornithine is metabolised to L-arginine. L-arginine stimulates the pituitary release of growth hormone. Burns or other injuries affect the state of L-arginine in tissues throughout the body. As De novo synthesis of L-arginine during these conditions is usually not sufficient for normal immune function, nor for normal protein synthesis, L-ornithine may have immunomodulatory and wound-healing activities under these conditions (by virtue of its metabolism to L-arginine).


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05-Jan-2021
29-Mar-2025
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Looking for 3184-13-2 / Ornithine API manufacturers, exporters & distributors?

Ornithine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Ornithine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ornithine manufacturer or Ornithine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ornithine manufacturer or Ornithine supplier.

PharmaCompass also assists you with knowing the Ornithine API Price utilized in the formulation of products. Ornithine API Price is not always fixed or binding as the Ornithine Price is obtained through a variety of data sources. The Ornithine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Ornithine

Synonyms

70-26-8, (s)-2,5-diaminopentanoic acid, (s)-ornithine, (s)-2,5-diaminovaleric acid, Ornithine [inn], (2s)-2,5-diaminopentanoic acid

Cas Number

3184-13-2

Unique Ingredient Identifier (UNII)

E524N2IXA3

About Ornithine

An amino acid produced in the urea cycle by the splitting off of urea from arginine.

Ornithine Manufacturers

A Ornithine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ornithine, including repackagers and relabelers. The FDA regulates Ornithine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ornithine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Ornithine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Ornithine Suppliers

A Ornithine supplier is an individual or a company that provides Ornithine active pharmaceutical ingredient (API) or Ornithine finished formulations upon request. The Ornithine suppliers may include Ornithine API manufacturers, exporters, distributors and traders.

click here to find a list of Ornithine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ornithine USDMF

A Ornithine DMF (Drug Master File) is a document detailing the whole manufacturing process of Ornithine active pharmaceutical ingredient (API) in detail. Different forms of Ornithine DMFs exist exist since differing nations have different regulations, such as Ornithine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Ornithine DMF submitted to regulatory agencies in the US is known as a USDMF. Ornithine USDMF includes data on Ornithine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ornithine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Ornithine suppliers with USDMF on PharmaCompass.

Ornithine GMP

Ornithine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ornithine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ornithine GMP manufacturer or Ornithine GMP API supplier for your needs.

Ornithine CoA

A Ornithine CoA (Certificate of Analysis) is a formal document that attests to Ornithine's compliance with Ornithine specifications and serves as a tool for batch-level quality control.

Ornithine CoA mostly includes findings from lab analyses of a specific batch. For each Ornithine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ornithine may be tested according to a variety of international standards, such as European Pharmacopoeia (Ornithine EP), Ornithine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ornithine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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