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Ondansetron HCl Dihydrate

Ondansetron HCl Dihydrate

Synopsis, Chemistry

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INJECTABLE;INJECTION - EQ 2MG BASE/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - EQ 24MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - EQ 4MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - EQ 8MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, SOLUTION;ORAL - EQ 4MG BASE/5ML

INJECTABLE;INJECTION - EQ 2MG BASE/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET;ORAL - EQ 24MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET;ORAL - EQ 4MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET;ORAL - EQ 8MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
SOLUTION;ORAL - EQ 4MG BASE/5ML

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Also known as: Ondansetron hcl, 99614-01-4, Zofran, Ondemet, Emeset, Ondansetron (hydrochloride)

Molecular Formula

C₁₈H₂₀ClN₃O

Molecular Weight

329.8 g/mol

InChI Key

MKBLHFILKIKSQM-UHFFFAOYSA-N

FDA UNII

2999F27MAD

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

1 2D Structure

Ondansetron HCl Dihydrate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one;hydrochloride

2.1.2 InChI

InChI=1S/C18H19N3O.ClH/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H

2.1.3 InChI Key

MKBLHFILKIKSQM-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl

2.2 Other Identifiers

2.2.1 UNII

2999F27MAD

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4h-carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-

2. Dihydrate, Ondansetron Monohydrochloride

3. Gr 38032f

4. Gr-38032f

5. Gr38032f

6. Hydrochloride, Ondansetron

7. Monohydrochloride Dihydrate, Ondansetron

8. Monohydrochloride, Ondansetron

9. Odt, Zofran

10. Ondansetron

11. Ondansetron Monohydrochloride

12. Ondansetron Monohydrochloride Dihydrate

13. Ondansetron, (+,-)-isomer

14. Ondansetron, (r)-isomer

15. Ondansetron, (s)-isomer

16. Sn 307

17. Sn-307

18. Sn307

19. Zofran

20. Zofran Odt

2.3.2 Depositor-Supplied Synonyms

1. Ondansetron Hcl

2. 99614-01-4

3. Zofran

4. Ondemet

5. Emeset

6. Ondansetron (hydrochloride)

7. Zofran Odt

8. Nsc 665799

9. Ondansetronhydrochloride

10. 2999f27mad

11. Nsc-665799

12. C18h20cln3o

13. 4h-carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-, Monohydrochloride

14. Emetron

15. 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-4h-carbazol-4-one Hydrochloride

16. 9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-1,2,3,9-tetrahydro-4h-carbazol-4-one Hydrochloride

17. 9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-2,3-dihydro-1h-carbazol-4(9h)-one Hydrochloride

18. Smr000469179

19. Gr 38032

20. Unii-2999f27mad

21. Sr-01000763250

22. Zofran Preservative Free

23. Zofran And Dextrose In Plastic Container

24. Cpd000469179

25. Ondansetron Hydrochloride Preservative Free

26. 9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-4h-carbazol-4-one Monohydrochloride

27. Schembl41455

28. Mls001304076

29. Mls001401397

30. Mls002222312

31. Regid_for_cid_68647

32. Gr 38032 Hcl

33. Ondansetron Hydrochloride, 98%

34. Chembl1201111

35. Ondansetron Hydrochloride- Bio-x

36. Ondansetron Hydrochloride And Dextrose In Plastic Container

37. Dtxsid701027913

38. Hms1571c18

39. Ondansetron Hydrochloride (zofran)

40. Hy-b0002

41. Ondansetron Hydrochloride And Sodium Chloride In Plastic Container

42. Mfcd00764297

43. Nsc665799

44. S1390

45. Ondansetron Hydrochloride [mi]

46. Akos015889292

47. Ab07046

48. Ccg-100852

49. Ccg-221058

50. Cs-1715

51. Gs-3597

52. H39o049

53. Nc00102

54. Ac-12464

55. Bo164177

56. Ondansetron Hydrochloride [who-dd]

57. Ondansetron Hydrochloride Anhydrous

58. O0407

59. Sw100810-5

60. Vu0424014-2

61. C90628

62. (+/-)-ondansetron Hydrochloride Anhydrous

63. A800774

64. Ondansetron Hydrochloride Anhydrous, (+/-)-

65. Q-201515

66. Sr-01000763250-5

67. Q27254405

68. 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one;hydrochloride

69. 1,2,3,4-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-9h-carbazol-4-one Hydrochloride

70. 4h-carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-, Hydrochloride (1:1)

71. 9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-2,3,4,9-tetrahydro-1h-carbazol-4-one Hydrochloride

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₂₀ClN₃O
Molecular Weight	329.8 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	329.1294900 g/mol
Monoisotopic Mass	329.1294900 g/mol
Topological Polar Surface Area	39.8 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	440
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Ondansetron hydrochloride
Drug Label	The active ingredient in ZOFRAN Tablets and ZOFRAN Oral Solution is ondansetron hydrochloride (HCl) as the dihydrate, the racemic form of ondansetron and a selective blocking agent of the serotonin 5-HT3 receptor type. Chemically it is (1, 2, 3, 9-te...
Active Ingredient	Ondansetron hydrochloride
Dosage Form	Tablet; Injectable; Solution
Route	oral; Injection; Oral
Strength	eq 4mg base; eq 2mg base/ml; eq 4mg base/5ml; eq 16mg; eq 16mg base; 16mg; eq 24mg base; eq 8mg base
Market Status	Tentative Approval; Prescription
Company	Amneal Pharms; Wockhardt; Silarx; Bedford; Hospira; Gland Pharma; Sun Pharm Inds (in); Teva; Apotex; Hikma Farmaceutica; Aurobindo Pharma; Natco Pharma; Taro; Sandoz; Par Pharm; Roxane; Glenmark Generics; Emcure Pharms; Fresenius Kabi Usa; Ipca Labs; Hikm

2 of 6
Drug Name	Ondansetron hydrochloride preservative free
Active Ingredient	Ondansetron hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 2mg base/ml
Market Status	Prescription
Company	Wockhardt; Hospira; Teva; Hikma Farmaceutica; Aurobindo Pharma; Sun Pharm Inds; Sandoz; Emcure Pharms; Fresenius Kabi Usa; Hikma Maple; Claris Lifesciences; Taro Pharms Ireland; Luitpold; Bedford Labs; Agila Speclts; Bd Rx

3 of 6
Drug Name	Zofran preservative free
Active Ingredient	Ondansetron hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 2mg base/ml
Market Status	Prescription
Company	Glaxosmithkline

4 of 6
Drug Name	Ondansetron hydrochloride
Drug Label	The active ingredient in ZOFRAN Tablets and ZOFRAN Oral Solution is ondansetron hydrochloride (HCl) as the dihydrate, the racemic form of ondansetron and a selective blocking agent of the serotonin 5-HT3 receptor type. Chemically it is (1, 2, 3, 9-te...
Active Ingredient	Ondansetron hydrochloride
Dosage Form	Tablet; Injectable; Solution
Route	oral; Injection; Oral
Strength	eq 4mg base; eq 2mg base/ml; eq 4mg base/5ml; eq 16mg; eq 16mg base; 16mg; eq 24mg base; eq 8mg base
Market Status	Tentative Approval; Prescription
Company	Amneal Pharms; Wockhardt; Silarx; Bedford; Hospira; Gland Pharma; Sun Pharm Inds (in); Teva; Apotex; Hikma Farmaceutica; Aurobindo Pharma; Natco Pharma; Taro; Sandoz; Par Pharm; Roxane; Glenmark Generics; Emcure Pharms; Fresenius Kabi Usa; Ipca Labs; Hikm

5 of 6
Drug Name	Ondansetron hydrochloride preservative free
Active Ingredient	Ondansetron hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 2mg base/ml
Market Status	Prescription
Company	Wockhardt; Hospira; Teva; Hikma Farmaceutica; Aurobindo Pharma; Sun Pharm Inds; Sandoz; Emcure Pharms; Fresenius Kabi Usa; Hikma Maple; Claris Lifesciences; Taro Pharms Ireland; Luitpold; Bedford Labs; Agila Speclts; Bd Rx

6 of 6
Drug Name	Zofran preservative free
Active Ingredient	Ondansetron hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 2mg base/ml
Market Status	Prescription
Company	Glaxosmithkline

4.2 Drug Indication

Treatment of alcohol use disorder

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Serotonin 5-HT3 Receptor Antagonists

Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS. (See all compounds classified as Serotonin 5-HT3 Receptor Antagonists.)

Antipruritics

Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Serotonin-3 Receptor Antagonist [EPC]; Serotonin 3 Receptor Antagonists [MoA]