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Chemistry

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Also known as: 1228013-30-6, Onatasertib, Cc223, Onatasertib [usan], Atg-008, I8ra3543sy
Molecular Formula
C21H27N5O3
Molecular Weight
397.5  g/mol
InChI Key
UFKLYTOEMRFKAD-UHFFFAOYSA-N
FDA UNII
I8RA3543SY

Onatasertib
Onatasertib is an orally available inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. Onatasertib inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays an important role downstream in the PI3K/AKT/mTOR signaling pathway, which is frequently dysregulated in human cancers.
1 2D Structure

Onatasertib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5-(4-methoxycyclohexyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one
2.1.2 InChI
InChI=1S/C21H27N5O3/c1-21(2,28)17-9-4-13(10-22-17)16-11-23-19-20(25-16)26(18(27)12-24-19)14-5-7-15(29-3)8-6-14/h4,9-11,14-15,28H,5-8,12H2,1-3H3,(H,23,24)
2.1.3 InChI Key
UFKLYTOEMRFKAD-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)(C1=NC=C(C=C1)C2=CN=C3C(=N2)N(C(=O)CN3)C4CCC(CC4)OC)O
2.2 Other Identifiers
2.2.1 UNII
I8RA3543SY
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-(4-methoxycyclohexyl)-3,4-dihydropyrazino(2,3-b)pyrazin-2(1h)-one

2. Cc0482223

2.3.2 Depositor-Supplied Synonyms

1. 1228013-30-6

2. Onatasertib

3. Cc223

4. Onatasertib [usan]

5. Atg-008

6. I8ra3543sy

7. Chembl3586404

8. Cc 223

9. Onatasertib (usan)

10. 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((1r,4r)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one

11. 3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5-(4-methoxycyclohexyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one

12. 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-(trans-4-methoxycyclohexyl)-3,4-dihydropyrazino(2,3-b)pyrazin-2(1h)-one

13. 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-(trans-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one

14. Pyrazino(2,3-b)pyrazin-2(1h)-one, 3,4-dihydro-7-(6-(1-hydroxy-1-methylethyl)-3-pyridinyl)-1-(trans-4-methoxycyclohexyl)-

15. Pyrazino[2,3-b]pyrazin-2(1h)-one, 3,4-dihydro-7-[6-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-(trans-4-methoxycyclohexyl)-

16. Compound 37 [pmid: 26083478]

17. Onatasertib [inn]

18. Unii-i8ra3543sy

19. Onatasertib [who-dd]

20. Schembl138069

21. Schembl153700

22. Schembl800493

23. Gtpl8914

24. Schembl16272828

25. Ex-a781

26. Bcp09953

27. Bdbm50092783

28. Mfcd28976054

29. Nsc792971

30. Nsc800982

31. S7886

32. Who 11237

33. Akos030526335

34. Zinc113219373

35. Zinc114617828

36. Ccg-268624

37. Cs-4560

38. Db12570

39. Nsc-792971

40. Nsc-800982

41. Sb19154

42. Ac-31533

43. As-35243

44. Hy-16956

45. Ft-0700128

46. A13078

47. D11663

48. J-690077

49. Q27075761

50. 1-((1beta,4alpha)-4-methoxycyclohexane-1-yl)-7-(2-(1-methyl-1-hydroxyethyl)-5-pyridyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine-2-one

51. 3,4-dihydro-7-(6-(1-hydroxy-1-methylethyl)-3-pyridinyl)-1-(trans-4-methoxycyclohexyl)pyrazino(2,3-b)pyrazin-2(1h)-one

52. 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one

2.4 Create Date
2012-08-19
3 Chemical and Physical Properties
Molecular Weight 397.5 g/mol
Molecular Formula C21H27N5O3
XLogP31.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass397.21138974 g/mol
Monoisotopic Mass397.21138974 g/mol
Topological Polar Surface Area101 Ų
Heavy Atom Count29
Formal Charge0
Complexity581
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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Looking for 1228013-30-6 / Onatasertib API manufacturers, exporters & distributors?

Onatasertib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Onatasertib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Onatasertib manufacturer or Onatasertib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Onatasertib manufacturer or Onatasertib supplier.

PharmaCompass also assists you with knowing the Onatasertib API Price utilized in the formulation of products. Onatasertib API Price is not always fixed or binding as the Onatasertib Price is obtained through a variety of data sources. The Onatasertib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Onatasertib

Synonyms

1228013-30-6, Cc223, Onatasertib [usan], Atg-008, I8ra3543sy, Chembl3586404

Cas Number

1228013-30-6

Unique Ingredient Identifier (UNII)

I8RA3543SY

About Onatasertib

Onatasertib is an orally available inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. Onatasertib inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays an important role downstream in the PI3K/AKT/mTOR signaling pathway, which is frequently dysregulated in human cancers.

Onatasertib Manufacturers

A Onatasertib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Onatasertib, including repackagers and relabelers. The FDA regulates Onatasertib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Onatasertib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Onatasertib Suppliers

A Onatasertib supplier is an individual or a company that provides Onatasertib active pharmaceutical ingredient (API) or Onatasertib finished formulations upon request. The Onatasertib suppliers may include Onatasertib API manufacturers, exporters, distributors and traders.

Onatasertib GMP

Onatasertib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Onatasertib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Onatasertib GMP manufacturer or Onatasertib GMP API supplier for your needs.

Onatasertib CoA

A Onatasertib CoA (Certificate of Analysis) is a formal document that attests to Onatasertib's compliance with Onatasertib specifications and serves as a tool for batch-level quality control.

Onatasertib CoA mostly includes findings from lab analyses of a specific batch. For each Onatasertib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Onatasertib may be tested according to a variety of international standards, such as European Pharmacopoeia (Onatasertib EP), Onatasertib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Onatasertib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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