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Chemistry

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Also known as: 865783-99-9, On-014185, Briciclib (on-013105), On 014185, Briciclib (on-014185), 865783-99-9 (free acid)
Molecular Formula
C19H23O10PS
Molecular Weight
474.4  g/mol
InChI Key
LXENKEWVEVKKGV-BQYQJAHWSA-N
FDA UNII
WG93X96336

ON 013105
Briciclib is a benzyl styryl sulfone analog, and a phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, briciclib is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D and eventually decrease tumor cell proliferation. Cyclin D, a member of the cyclin family of cell cycle regulators, plays a key role in cell cycle division and is often overexpressed in a variety of hematologic and solid tumors and is correlated with poor prognosis. suppresses cyclin D1 accumulation in cancer cells.
1 2D Structure

ON 013105

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]phenyl] dihydrogen phosphate
2.1.2 InChI
InChI=1S/C19H23O10PS/c1-25-14-10-17(27-3)15(18(11-14)28-4)7-8-31(23,24)12-13-5-6-16(26-2)19(9-13)29-30(20,21)22/h5-11H,12H2,1-4H3,(H2,20,21,22)/b8-7+
2.1.3 InChI Key
LXENKEWVEVKKGV-BQYQJAHWSA-N
2.1.4 Canonical SMILES
COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)OP(=O)(O)O
2.1.5 Isomeric SMILES
COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)OP(=O)(O)O
2.2 Other Identifiers
2.2.1 UNII
WG93X96336
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 865783-99-9

2. On-014185

3. Briciclib (on-013105)

4. On 014185

5. Briciclib (on-014185)

6. 865783-99-9 (free Acid)

7. Wg93x96336

8. (e)-2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl Dihydrogen Phosphate

9. Phenol, 2-methoxy-5-((((1e)-2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl)-, 1-(dihydrogen Phosphate)

10. Phenol, 2-methoxy-5-[[[(1e)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]-, 1-(dihydrogen Phosphate)

11. Briciclib [usan:inn]

12. On-013105

13. Unii-wg93x96336

14. Briciclib [usan]

15. Briciclib [inn]

16. Briciclib (usan/inn)

17. Briciclib [who-dd]

18. Briciclib; On 014185

19. Schembl1634579

20. Schembl1634581

21. Chembl1206245

22. [2-methoxy-5-[[(e)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]phenyl] Dihydrogen Phosphate

23. Amy42169

24. Bcp17292

25. Ex-a2492

26. Mfcd22665751

27. S6533

28. Zinc28965775

29. Cs-5589

30. Db12004

31. Ac-36098

32. Hy-16366

33. Briciclib(on 013105,on 014185)

34. D10614

35. Q27292622

36. (2-methoxy-5-{[(e)-2-(2,4,6-trimethoxyphenyl)ethenesulfonyl]methyl}phenoxy)phosphonic Acid

37. (e)-5-((2,4,6-trimethoxystyrylsulfonyl)methyl)-2-methoxyphenyl Dihydrogen Phosphate

38. On013105; On-013105; On 013105;on-014185;on 014185;on014185

39. (e)-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)-2-methoxyphenyl Dihydrogen Phosphate

40. 2-methoxy-5-(((2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl)phenyl Dihydrogen Phosphate

41. Phenol, 2-methoxy-5-[[[(1e)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl] Methyl]-, 1-(dihydrogen Phosphate)

42. Phenol,2-methoxy-5-[[[(1e)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]-,1-(dihydrogen Phosphate)

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 474.4 g/mol
Molecular Formula C19H23O10PS
XLogP31.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count10
Exact Mass474.07495510 g/mol
Monoisotopic Mass474.07495510 g/mol
Topological Polar Surface Area146 Ų
Heavy Atom Count31
Formal Charge0
Complexity717
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 865783-99-9 / ON 013105 API manufacturers, exporters & distributors?

ON 013105 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of ON 013105 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right ON 013105 manufacturer or ON 013105 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred ON 013105 manufacturer or ON 013105 supplier.

PharmaCompass also assists you with knowing the ON 013105 API Price utilized in the formulation of products. ON 013105 API Price is not always fixed or binding as the ON 013105 Price is obtained through a variety of data sources. The ON 013105 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

ON 013105

Synonyms

865783-99-9, On-014185, Briciclib (on-013105), On 014185, Briciclib (on-014185), 865783-99-9 (free acid)

Cas Number

865783-99-9

Unique Ingredient Identifier (UNII)

WG93X96336

About ON 013105

Briciclib is a benzyl styryl sulfone analog, and a phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, briciclib is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D and eventually decrease tumor cell proliferation. Cyclin D, a member of the cyclin family of cell cycle regulators, plays a key role in cell cycle division and is often overexpressed in a variety of hematologic and solid tumors and is correlated with poor prognosis. suppresses cyclin D1 accumulation in cancer cells.

ON 013105 Manufacturers

A ON 013105 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of ON 013105, including repackagers and relabelers. The FDA regulates ON 013105 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. ON 013105 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

ON 013105 Suppliers

A ON 013105 supplier is an individual or a company that provides ON 013105 active pharmaceutical ingredient (API) or ON 013105 finished formulations upon request. The ON 013105 suppliers may include ON 013105 API manufacturers, exporters, distributors and traders.

ON 013105 GMP

ON 013105 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of ON 013105 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right ON 013105 GMP manufacturer or ON 013105 GMP API supplier for your needs.

ON 013105 CoA

A ON 013105 CoA (Certificate of Analysis) is a formal document that attests to ON 013105's compliance with ON 013105 specifications and serves as a tool for batch-level quality control.

ON 013105 CoA mostly includes findings from lab analyses of a specific batch. For each ON 013105 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

ON 013105 may be tested according to a variety of international standards, such as European Pharmacopoeia (ON 013105 EP), ON 013105 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (ON 013105 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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