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Synopsis

ACTIVE PHARMA INGREDIENTS

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CEP/COS

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NDC API

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0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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DRUG PRODUCT COMPOSITIONS

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0EXCIPIENTS BY APPLICATIONS

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API REF. PRICE (USD/KG)

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Chemistry

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Also known as: Orphanin fq, 170713-75-4, Orphanin fq (swine), Nociceptin/orphanin fq, Nociceptin (1-17), Fggftgarksarklanq
Molecular Formula
C79H129N27O22
Molecular Weight
1809.0  g/mol
InChI Key
PULGYDLMFSFVBL-SMFNREODSA-N
FDA UNII
7AYI9N34FF

Nociceptin
1 2D Structure

Nociceptin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-5-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-5-oxopentanoic acid
2.1.2 InChI
InChI=1S/C79H129N27O22/c1-41(2)33-54(72(122)95-44(5)66(116)103-56(36-59(84)110)73(123)102-53(77(127)128)27-28-58(83)109)104-70(120)49(23-13-15-29-80)100-69(119)52(26-18-32-90-79(87)88)99-65(115)43(4)96-75(125)57(40-107)105-71(121)50(24-14-16-30-81)101-68(118)51(25-17-31-89-78(85)86)98-64(114)42(3)94-61(112)39-93-76(126)63(45(6)108)106-74(124)55(35-47-21-11-8-12-22-47)97-62(113)38-91-60(111)37-92-67(117)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,107-108H,13-18,23-40,80-82H2,1-6H3,(H2,83,109)(H2,84,110)(H,91,111)(H,92,117)(H,93,126)(H,94,112)(H,95,122)(H,96,125)(H,97,113)(H,98,114)(H,99,115)(H,100,119)(H,101,118)(H,102,123)(H,103,116)(H,104,120)(H,105,121)(H,106,124)(H,127,128)(H4,85,86,89)(H4,87,88,90)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1
2.1.3 InChI Key
PULGYDLMFSFVBL-SMFNREODSA-N
2.1.4 Canonical SMILES
CC(C)CC(C(=O)NC(C)C(=O)NC(CC(=O)N)C(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)CNC(=O)C(C(C)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)C(CC2=CC=CC=C2)N
2.1.5 Isomeric SMILES
C[C@H]([C@@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)N)O
2.2 Other Identifiers
2.2.1 UNII
7AYI9N34FF
2.3 Synonyms
2.3.1 MeSH Synonyms

1. N-ofq Peptide

2. Nociceptin-orphanin Fq

3. Orphanin Fq

2.3.2 Depositor-Supplied Synonyms

1. Orphanin Fq

2. 170713-75-4

3. Orphanin Fq (swine)

4. Nociceptin/orphanin Fq

5. Nociceptin (1-17)

6. Fggftgarksarklanq

7. 7ayi9n34ff

8. Chebi:80266

9. L-glutamine, L-phenylalanylglycylglycyl-l-phenylalanyl-l-threonylglycyl-l-alanyl-l-arginyl-l-lysyl-l-seryl-l-alanyl-l-arginyl-l-lysyl-l-leucyl-l-alanyl-l-asparaginyl-

10. Orphanin Fq (rat)

11. Orphanin Fq (human)

12. Human Nociceptin

13. N-ofq Peptide

14. Nociceptin (human)

15. Orphanin Fq (pig)

16. Nociceptin-orphanin Fq

17. Unii-7ayi9n34ff

18. Orphanin-fq

19. Orphanin Fqorphanin Fq

20. Nociceptin [mi]

21. Chembl396460

22. Gtpl1681

23. Dtxsid60168933

24. Bdbm50004178

25. Akos024458690

26. C79h129n27o22

27. Ncgc00167266-01

28. Pheglyglyphethrglyalaarglysseralaarglysleualaasngln

29. Q4327722

30. Y-100028

31. Phe-gly-gly-phe-thr-gly-ala-arg-lys-ser-unk-ala-arg-lys-leu-ala-asn-gln

32. L-phe-gly-gly-l-phe-l-thr-gly-l-ala-l-arg-l-lys-l-ser-l-ala-l-arg-l-lys-l-leu-l-ala-l-asn-l-gln

33. L-phenylalanylglycylglycyl-l-phenylalanyl-l-threonylglycyl-l-alanyl-l-arginyl-l-lysyl-l-seryl-l-alanyl-l-arginyl-l-lysyl-l-leucyl-l-alanyl-l-asparaginyl-l-glutamine

2.4 Create Date
2007-07-03
3 Chemical and Physical Properties
Molecular Weight 1809.0 g/mol
Molecular Formula C79H129N27O22
XLogP3-10.2
Hydrogen Bond Donor Count30
Hydrogen Bond Acceptor Count27
Rotatable Bond Count64
Exact Mass1807.98054885 g/mol
Monoisotopic Mass1807.98054885 g/mol
Topological Polar Surface Area831 Ų
Heavy Atom Count128
Formal Charge0
Complexity3720
Isotope Atom Count0
Defined Atom Stereocenter Count15
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


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Looking for 170713-75-4 / Nociceptin API manufacturers, exporters & distributors?

Nociceptin manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Nociceptin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Nociceptin manufacturer or Nociceptin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Nociceptin manufacturer or Nociceptin supplier.

PharmaCompass also assists you with knowing the Nociceptin API Price utilized in the formulation of products. Nociceptin API Price is not always fixed or binding as the Nociceptin Price is obtained through a variety of data sources. The Nociceptin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Nociceptin

Synonyms

Orphanin fq, 170713-75-4, Orphanin fq (swine), Nociceptin/orphanin fq, Nociceptin (1-17), Fggftgarksarklanq

Cas Number

170713-75-4

Unique Ingredient Identifier (UNII)

7AYI9N34FF

Nociceptin Manufacturers

A Nociceptin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nociceptin, including repackagers and relabelers. The FDA regulates Nociceptin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nociceptin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Nociceptin Suppliers

A Nociceptin supplier is an individual or a company that provides Nociceptin active pharmaceutical ingredient (API) or Nociceptin finished formulations upon request. The Nociceptin suppliers may include Nociceptin API manufacturers, exporters, distributors and traders.

Nociceptin GMP

Nociceptin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Nociceptin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nociceptin GMP manufacturer or Nociceptin GMP API supplier for your needs.

Nociceptin CoA

A Nociceptin CoA (Certificate of Analysis) is a formal document that attests to Nociceptin's compliance with Nociceptin specifications and serves as a tool for batch-level quality control.

Nociceptin CoA mostly includes findings from lab analyses of a specific batch. For each Nociceptin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Nociceptin may be tested according to a variety of international standards, such as European Pharmacopoeia (Nociceptin EP), Nociceptin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nociceptin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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