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Chemistry

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Also known as: 53179-07-0, 3-(2-methoxyphenoxy)-n-methyl-3-phenylpropan-1-amine, Compound 89218, 3-(2-methoxyphenoxy)-n-methyl-3-phenylpropylamine, 57226-61-6, Dl-n-methyl-3-(o-methoxyphenoxy)-n-methyl-3-phenylpropylamine
Molecular Formula
C17H21NO2
Molecular Weight
271.35  g/mol
InChI Key
ITJNARMNRKSWTA-UHFFFAOYSA-N
FDA UNII
17NV064B2D

Nisoxetine
Nisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s. It was originally investigated as an antidepressant but has no current clinical applications aside from being a research standard SNRI. It has been used to research obesity and energy balance, and exerts some local analgesia effects.
1 2D Structure

Nisoxetine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine
2.1.2 InChI
InChI=1S/C17H21NO2/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2/h3-11,15,18H,12-13H2,1-2H3
2.1.3 InChI Key
ITJNARMNRKSWTA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CNCCC(C1=CC=CC=C1)OC2=CC=CC=C2OC
2.2 Other Identifiers
2.2.1 UNII
17NV064B2D
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-(2-methoxyphenoxy)-n-methyl-3-phenylpropylamine

2. 3-(o-methoxyphenoxy)-n-methyl-3-phenylpropylamine

3. Dl-n-methyl-3-(o-methoxyphenoxy)-n-methyl-3-phenylpropylamine

4. Lilly 135252

5. Lilly 94939

6. Ly 135252

7. Ly 94939

8. Ly-135252

9. N-methyl-gamma-(2-methylphenoxy)phenylpropanolamine

10. Nisoxetine Hydrochloride

11. Nisoxetine Hydrochloride, (+-)-isomer

12. Nisoxetine, (+-)-isomer

2.3.2 Depositor-Supplied Synonyms

1. 53179-07-0

2. 3-(2-methoxyphenoxy)-n-methyl-3-phenylpropan-1-amine

3. Compound 89218

4. 3-(2-methoxyphenoxy)-n-methyl-3-phenylpropylamine

5. 57226-61-6

6. Dl-n-methyl-3-(o-methoxyphenoxy)-n-methyl-3-phenylpropylamine

7. Nsc-283481

8. 3-(o-methoxyphenoxy)-n-methyl-3-phenylpropylamine

9. N-methyl-gamma-(2-methylphenoxy)phenylpropanolamine

10. Chembl295467

11. Chebi:73410

12. 17nv064b2d

13. Benzenepropanamine, Gamma-(2-methoxyphenoxy)-n-methyl-

14. Compound 89218; Nsc 283481

15. Ncgc00015715-04

16. Nisoxetine Inhibitor

17. Dsstox_cid_25175

18. Dsstox_rid_80724

19. Dsstox_gsid_45175

20. Nisoxetina

21. Nisoxetinum

22. Nisoxetine [usan:inn]

23. Cas-53179-07-0

24. Ly-94939

25. Unii-17nv064b2d

26. Nsc 283481

27. Ly 94939

28. Nisoxetine [inn]

29. Antioxidant1425

30. Nisoxetine (usan/inn)

31. Prestwick0_000910

32. Prestwick1_000910

33. Prestwick2_000910

34. Prestwick3_000910

35. Nisoxetine [usan]

36. Lopac0_000901

37. Bspbio_000760

38. Compound-89218

39. Schembl124289

40. Spbio_002959

41. Bpbio1_000836

42. Gtpl4637

43. Dtxsid0045175

44. Bdbm22417

45. Hms2089k13

46. Tox21 110203

47. Tox21_110203

48. Nsc283481

49. Pdsp1_000507

50. Pdsp2_000505

51. Tox21_110203_1

52. Ccg-204983

53. Db09186

54. Sdccgsbi-0050876.p002

55. Ncgc00015715-03

56. Ncgc00015715-05

57. Ncgc00015715-06

58. Ncgc00015715-08

59. Ncgc00015715-15

60. Ncgc00024945-02

61. Ncgc00024945-03

62. As-16468

63. Ab00514644

64. D05173

65. Ab00514644-07

66. N-methyl 3(o-methoxyphenoxy)-3-phenylpropylamine

67. N-methyl 3-(o-methoxyphenoxy)-3-phenylpropylamine

68. Q906885

69. [3-(2-methoxyphenoxy)-3-phenylpropyl](methyl)amine

70. N-methyl-3-phenyl-3-(o-methoxyphenoxy)-propylamine

71. Brd-a95696066-003-03-9

72. Brd-a95696066-003-06-2

73. (+/-)-3-(o-methoxyphenoxy)-n-methyl-3-phenylpropylamine

74. Benzenepropanamine, .gamma.-(2-methoxyphenoxy)-n-methyl-, (+/-)-

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 271.35 g/mol
Molecular Formula C17H21NO2
XLogP33.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count7
Exact Mass271.157228913 g/mol
Monoisotopic Mass271.157228913 g/mol
Topological Polar Surface Area30.5 Ų
Heavy Atom Count20
Formal Charge0
Complexity253
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 53179-07-0 / Nisoxetine API manufacturers, exporters & distributors?

Nisoxetine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Nisoxetine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Nisoxetine manufacturer or Nisoxetine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Nisoxetine manufacturer or Nisoxetine supplier.

PharmaCompass also assists you with knowing the Nisoxetine API Price utilized in the formulation of products. Nisoxetine API Price is not always fixed or binding as the Nisoxetine Price is obtained through a variety of data sources. The Nisoxetine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Nisoxetine

Synonyms

53179-07-0, 3-(2-methoxyphenoxy)-n-methyl-3-phenylpropan-1-amine, Compound 89218, 3-(2-methoxyphenoxy)-n-methyl-3-phenylpropylamine, 57226-61-6, Dl-n-methyl-3-(o-methoxyphenoxy)-n-methyl-3-phenylpropylamine

Cas Number

53179-07-0

Unique Ingredient Identifier (UNII)

17NV064B2D

About Nisoxetine

Nisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s. It was originally investigated as an antidepressant but has no current clinical applications aside from being a research standard SNRI. It has been used to research obesity and energy balance, and exerts some local analgesia effects.

Nisoxetine Manufacturers

A Nisoxetine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nisoxetine, including repackagers and relabelers. The FDA regulates Nisoxetine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nisoxetine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Nisoxetine Suppliers

A Nisoxetine supplier is an individual or a company that provides Nisoxetine active pharmaceutical ingredient (API) or Nisoxetine finished formulations upon request. The Nisoxetine suppliers may include Nisoxetine API manufacturers, exporters, distributors and traders.

Nisoxetine GMP

Nisoxetine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Nisoxetine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nisoxetine GMP manufacturer or Nisoxetine GMP API supplier for your needs.

Nisoxetine CoA

A Nisoxetine CoA (Certificate of Analysis) is a formal document that attests to Nisoxetine's compliance with Nisoxetine specifications and serves as a tool for batch-level quality control.

Nisoxetine CoA mostly includes findings from lab analyses of a specific batch. For each Nisoxetine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Nisoxetine may be tested according to a variety of international standards, such as European Pharmacopoeia (Nisoxetine EP), Nisoxetine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nisoxetine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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