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Nikethamide

Nikethamide

Synopsis, Chemistry

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Also known as: N,n-diethylnicotinamide, 59-26-7, Nicethamide, Anacardone, Coramine, Nikethyl

Molecular Formula

C₁₀H₁₄N₂O

Molecular Weight

178.23 g/mol

InChI Key

NCYVXEGFNDZQCU-UHFFFAOYSA-N

FDA UNII

368IVD6M32

A central nervous system stimulant. It was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1229)

1 2D Structure

Nikethamide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N,N-diethylpyridine-3-carboxamide

2.1.2 InChI

InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3

2.1.3 InChI Key

NCYVXEGFNDZQCU-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCN(CC)C(=O)C1=CN=CC=C1

2.2 Other Identifiers

2.2.1 UNII

368IVD6M32

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Coramin

2. Coramine

3. Cordiamine

4. Corethamid

5. Diethylamide, Nicotinic

6. Diethylnicotinamid

7. Nicethamide

8. Nicotinic Diethylamide

9. Nizethamid

2.3.2 Depositor-Supplied Synonyms

1. N,n-diethylnicotinamide

2. 59-26-7

3. Nicethamide

4. Anacardone

5. Coramine

6. Nikethyl

7. Corvotone

8. Corvin

9. 3-pyridinecarboxamide, N,n-diethyl-

10. Anacordone

11. Carbamidal

12. Nicamide

13. Nicetamide

14. Nicorine

15. Pyricardyl

16. Niamine

17. Nicotinic Acid Diethylamide

18. Camphozone

19. Canfodiamina

20. Cardiamide

21. Cardiamina

22. Cardiamine

23. Coraetamidum

24. Coraethamide

25. Coraethamidum

26. Cordiamine

27. Corethamide

28. Dynamicarde

29. Nicordamin

30. Niketamide

31. Niketharol

32. Niketilamid

33. Niquetamida

34. Procardine

35. Salvacorin

36. Stellamine

37. Ventramine

38. Astrocar

39. Cardamine

40. Cardiagen

41. Cardiamid

42. Cardimon

43. Citocor

44. Coracon

45. Coralept

46. Coravita

47. Corazone

48. Cordiamid

49. Cordiamin

50. Corditon

51. Cordynil

52. Corediol

53. Corespin

54. Coretone

55. Cormotyl

56. Cornotone

57. Corotonin

58. Corovit

59. Corvitan

60. Corvitol

61. Corywas

62. Danamine

63. Dinacoryl

64. Dynacoryl

65. Elitone

66. Eucoran

67. Hansacor

68. Inicardio

69. Kardiamid

70. Kardonyl

71. Kordiamin

72. Leptamin

73. Mediamid

74. Nicoryl

75. Nikardin

76. Niketamid

77. Nikorin

78. Percoral

79. Procorman

80. Reformin

81. Rehormin

82. Salvacard

83. Sancora

84. Solyacord

85. Stiminol

86. Stimulin

87. Tonocor

88. Corivo

89. Cormed

90. Cormid

91. Diethylnicotinamide

92. Diethyl-nicotamide

93. Nisetamide

94. N,n-diethylpyridine-3-carboxamide

95. Nicor

96. Dietilamide-carbopiridina

97. Diaethyl-nicotinamid

98. Pyridine-3-carboxydiethylamide

99. Carditonic

100. Vasazol

101. Pyridine-3-carboxylic Acid Diethylamide

102. N,n-diethyl-3-pyridinecarboxamide

103. .beta.-pyrimidum

104. Nicotinamide, N,n-diethyl-

105. Ni-cor

106. Diethylamid Kyseliny Nikotinove

107. Nsc-130820

108. 368ivd6m32

109. Nikethamide (inn)

110. Ncgc00166026-01

111. Nicaethamidum

112. Nicethamidum

113. Nicotinamide,n-diethyl-

114. Beta-pyrimidum

115. Nikethamide [inn]

116. Wln: T6nj Cvn2&2

117. Nicetamide [dcit]

118. 3-pyridinecarboxamide,n-diethyl-

119. Nicetamida

120. Coramin

121. Nicetamida [inn-spanish]

122. Nicethamidum [inn-latin]

123. Diaethyl-nicotinamid [german]

124. Diaethylamidum Acidi Nicotinici

125. Einecs 200-418-5

126. Mfcd00006386

127. Nsc 130820

128. Diethylamid Kyseliny Nikotinove [czech]

129. Brn 0005743

130. Nickethamide

131. Niketamine

132. Nikethamide [inn:ban:nf]

133. Ecoran

134. Unii-368ivd6m32

135. Ai3-01438

136. Coractiv N

137. Carditonic (tn)

138. N,n-diethyl Nicotinamide

139. Nikethamide [mi]

140. Dsstox_cid_26524

141. Dsstox_rid_81689

142. Nikethamide [mart.]

143. Dsstox_gsid_46524

144. Nikethamide [who-dd]

145. Mls004773905

146. Schembl246456

147. N,n-diethylnicotinamide, 99%

148. Zinc1814

149. Chembl2104607

150. Dtxsid9046524

151. 3-(n,n-diethylcarbamoyl)pyridine

152. Chebi:134814

153. Hms3264d18

154. Hms3886g05

155. Nikethamide [ep Monograph]

156. Pharmakon1600-01506157

157. Hy-b1280

158. Nsc62103

159. Tox21_112295

160. Bdbm50248014

161. Nsc-62103

162. Nsc130820

163. Nsc169863

164. Nsc760377

165. S4887

166. Akos003607578

167. Ccg-213619

168. Cs-8003

169. Db13655

170. Mb00187

171. Nsc-169863

172. Nsc-760377

173. Cas-59-26-7

174. Ncgc00166026-02

175. Ac-12043

176. Ac-31724

177. As-48195

178. Smr000059067

179. Db-053354

180. D0514

181. D07408

182. F19704

183. Ab01563149_01

184. Q902548

185. Sr-01000939653

186. Sr-01000939653-2

187. W-105333

188. N,n-diethylnicotinamide, Tested According To Ph.eur.

189. Nikethamide, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₄N₂O
Molecular Weight	178.23 g/mol
XLogP3	0.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	178.110613074 g/mol
Monoisotopic Mass	178.110613074 g/mol
Topological Polar Surface Area	33.2 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	166
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Convulsants

Substances that act in the brain stem or spinal cord to produce tonic or clonic convulsions, often by removing normal inhibitory tone. They were formerly used to stimulate respiration or as antidotes to barbiturate overdose. They are now most commonly used as experimental tools. (See all compounds classified as Convulsants.)

Central Nervous System Stimulants

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)

4.2 ATC Code

R - Respiratory system

R07 - Other respiratory system products

R07A - Other respiratory system products

R07AB - Respiratory stimulants

R07AB02 - Nikethamide