Niaprazine

Synopsis, Chemistry

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Also known as: 27367-90-4, Nopron, 1709 cerm, Niaprazine, (+)-, Niaprazine, (-)-, 1709cerm; nopron

Molecular Formula

C₂₀H₂₅FN₄O

Molecular Weight

356.4 g/mol

InChI Key

RSKQGBFMNPDPLR-UHFFFAOYSA-N

FDA UNII

R2H3YN6E3L

Niaprazine is a selective brain catecholamine depletor.

1 2D Structure

Niaprazine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl]pyridine-3-carboxamide

2.1.2 InChI

InChI=1S/C20H25FN4O/c1-16(23-20(26)17-3-2-9-22-15-17)8-10-24-11-13-25(14-12-24)19-6-4-18(21)5-7-19/h2-7,9,15-16H,8,10-14H2,1H3,(H,23,26)

2.1.3 InChI Key

RSKQGBFMNPDPLR-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(CCN1CCN(CC1)C2=CC=C(C=C2)F)NC(=O)C3=CN=CC=C3

2.2 Other Identifiers

2.2.1 UNII

R2H3YN6E3L

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Niaprazine Trihydrochloride

2. Nopron

2.3.2 Depositor-Supplied Synonyms

1. 27367-90-4

2. Nopron

3. 1709 Cerm

4. Niaprazine, (+)-

5. Niaprazine, (-)-

6. 1709cerm; Nopron

7. R2h3yn6e3l

8. N-(4-(4-(4-fluorophenyl)piperazin-1-yl)butan-2-yl)nicotinamide

9. 1709cerm

10. 5qkw305n9f

11. 1709-cerm

12. Niaprazine (inn)

13. N-(3-(4-(4-fluorophenyl)-1-piperazinyl)-1-methylpropyl)-3-pyridinecarboxamide

14. N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl]pyridine-3-carboxamide

15. J10.716f

16. Niaprazine [inn]

17. 1346q758l9

18. Nicotinamide, N-(3-(4-(p-fluorophenyl)-1-piperazinyl)-1-methylpropyl)-

19. 3-pyridinecarboxamide, N-(3-(4-(4-fluorophenyl)-1-piperazinyl)-1-methylpropyl)-

20. Niaprazina

21. Niaprazinum

22. Niaprazine [inn:dcf]

23. Niaprazinum [inn-latin]

24. Niaprazina [inn-spanish]

25. 3-pyridinecarboxamide, N-(3-(4-(4-fluorophenyl)-1-piperazinyl)-1-methylpropyl)-, (+)-

26. 3-pyridinecarboxamide, N-(3-(4-(4-fluorophenyl)-1-piperazinyl)-1-methylpropyl)-, (-)-

27. 119306-37-5

28. 119328-74-4

29. Einecs 248-431-5

30. Unii-r2h3yn6e3l

31. Brn 0844157

32. N-{4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl}pyridine-3-carboxamide

33. Nopron (tn)

34. Niaprazine [mi]

35. N-(3-(4-(p-fluorophenyl)-1-piperazinyl)-1-methylpropyl)nicotinamide

36. Niaprazine [mart.]

37. Niaprazine [who-dd]

38. Unii-5qkw305n9f

39. Schembl352977

40. Chembl2105141

41. Dtxsid10865369

42. Chebi:135505

43. Unii-1346q758l9

44. Db13687

45. Ac-36434

46. Bs-49185

47. Hy-105542

48. Cs-0026220

49. Ft-0687290

50. D07333

51. E75895

52. Q631457

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₅FN₄O
Molecular Weight	356.4 g/mol
XLogP3	2.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	356.20123960 g/mol
Monoisotopic Mass	356.20123960 g/mol
Topological Polar Surface Area	48.5 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	434
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1