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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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API Suppliers

API Suppliers

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

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Listed Suppliers

Other Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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Others

FINISHED DOSAGE FORMULATIONS

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FDA Orange Book

FDA (Orange Book)

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Europe

Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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Listed Dossiers

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

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US Patents

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US Exclusivities

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Health Canada Patents

API REF. PRICE (USD/KG)

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GLOBAL SALES INFORMATION

US Medicaid

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Chemistry

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Also known as: 1254036-71-9, Gsk-2269557 free base, Gsk2269557, Nemiralisib [usan], Oep8jj3ozr, Gsk2269557a
Molecular Formula
C26H28N6O
Molecular Weight
440.5  g/mol
InChI Key
MCIDWGZGWVSZMK-UHFFFAOYSA-N
FDA UNII
OEP8JJ3OZR

Nemiralisib
Nemiralisib is under investigation in clinical trial NCT03345407 (Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)).
1 2D Structure

Nemiralisib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[6-(1H-indol-4-yl)-1H-indazol-4-yl]-5-[(4-propan-2-ylpiperazin-1-yl)methyl]-1,3-oxazole
2.1.2 InChI
InChI=1S/C26H28N6O/c1-17(2)32-10-8-31(9-11-32)16-19-14-28-26(33-19)22-12-18(13-25-23(22)15-29-30-25)20-4-3-5-24-21(20)6-7-27-24/h3-7,12-15,17,27H,8-11,16H2,1-2H3,(H,29,30)
2.1.3 InChI Key
MCIDWGZGWVSZMK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)N1CCN(CC1)CC2=CN=C(O2)C3=C4C=NNC4=CC(=C3)C5=C6C=CNC6=CC=C5
2.2 Other Identifiers
2.2.1 UNII
OEP8JJ3OZR
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 6-(1h-indol-4-yl)-4-(5-((4-(1-methylethyl)-1-piperazinyl)methyl)-1,3-oxazol-2-yl)-1h-indazole

2. Gsk2269557

2.3.2 Depositor-Supplied Synonyms

1. 1254036-71-9

2. Gsk-2269557 Free Base

3. Gsk2269557

4. Nemiralisib [usan]

5. Oep8jj3ozr

6. Gsk2269557a

7. 2-[6-(1h-indol-4-yl)-1h-indazol-4-yl]-5-[(4-propan-2-ylpiperazin-1-yl)methyl]-1,3-oxazole

8. Chembl2216859

9. Gsk2269557 (free Base)

10. Gsk-2269557a

11. 6-(1h-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1h-indazole

12. 1h-indazole, 6-(1h-indol-4-yl)-4-(5-((4-(1-methylethyl)-1-piperazinyl)methyl)-2-oxazolyl)-

13. 1h-indazole, 6-(1h-indol-4-yl)-4-[5-[[4-(1-methylethyl)-1-piperazinyl]methyl]-2-oxazolyl]-

14. 6-(1h-indol-4-yl)-4-(5-((4-(1-methylethyl)-1-piperazinyl)methyl)-1,3-oxazol-2-yl)-1h-indazole

15. Gsk2269557 Free Base

16. Unii-oep8jj3ozr

17. Nemiralisib [inn]

18. Nemiralisib (usan/inn)

19. Nemiralisib [who-dd]

20. Schembl109919

21. Gtpl9425

22. Pi3kdelta Inhibitor Gs2269557

23. Ex-a5754

24. Bdbm50004529

25. Hy-19535a

26. S7937

27. Zinc95564436

28. Ccg-269127

29. Compound 2 [pmid: 26301626]

30. Cs-5683

31. Ac-35584

32. Da-36928

33. Ft-0716060

34. D11267

35. Q27467143

36. 2-(6-(1h-indol-4-yl)-1h-indazol-4-yl)-5-((4-isopropylpiperazin-1-yl)methyl)oxazole

37. 4-(5-(4-isopropyl-1-piperazinyl)methyl-2-oxazolyl)-6-(1h-indole-4-yl)-1h-indazole

38. 6-(1h-indol-4-yl)-4-(5-((4-(1-methylethyl)-1-piperazinyl)methyl)-2-oxazolyl)-1h-indazole

39. Vvx

2.4 Create Date
2010-12-06
3 Chemical and Physical Properties
Molecular Weight 440.5 g/mol
Molecular Formula C26H28N6O
XLogP33.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass440.23245954 g/mol
Monoisotopic Mass440.23245954 g/mol
Topological Polar Surface Area77 Ų
Heavy Atom Count33
Formal Charge0
Complexity655
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)


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Looking for 1254036-71-9 / Nemiralisib API manufacturers, exporters & distributors?

Nemiralisib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Nemiralisib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Nemiralisib manufacturer or Nemiralisib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Nemiralisib manufacturer or Nemiralisib supplier.

PharmaCompass also assists you with knowing the Nemiralisib API Price utilized in the formulation of products. Nemiralisib API Price is not always fixed or binding as the Nemiralisib Price is obtained through a variety of data sources. The Nemiralisib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Nemiralisib

Synonyms

1254036-71-9, Gsk-2269557 free base, Gsk2269557, Nemiralisib [usan], Oep8jj3ozr, Gsk2269557a

Cas Number

1254036-71-9

Unique Ingredient Identifier (UNII)

OEP8JJ3OZR

About Nemiralisib

Nemiralisib is under investigation in clinical trial NCT03345407 (Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)).

Nemiralisib Manufacturers

A Nemiralisib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nemiralisib, including repackagers and relabelers. The FDA regulates Nemiralisib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nemiralisib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Nemiralisib Suppliers

A Nemiralisib supplier is an individual or a company that provides Nemiralisib active pharmaceutical ingredient (API) or Nemiralisib finished formulations upon request. The Nemiralisib suppliers may include Nemiralisib API manufacturers, exporters, distributors and traders.

Nemiralisib GMP

Nemiralisib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Nemiralisib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nemiralisib GMP manufacturer or Nemiralisib GMP API supplier for your needs.

Nemiralisib CoA

A Nemiralisib CoA (Certificate of Analysis) is a formal document that attests to Nemiralisib's compliance with Nemiralisib specifications and serves as a tool for batch-level quality control.

Nemiralisib CoA mostly includes findings from lab analyses of a specific batch. For each Nemiralisib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Nemiralisib may be tested according to a variety of international standards, such as European Pharmacopoeia (Nemiralisib EP), Nemiralisib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nemiralisib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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