Find Verapamil Hydrochloride manufacturers, exporters & distributors on PharmaCompass

NCGC00024710-03

NCGC00024710-03

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

32 API Suppliers, 17 USDMF, 10 CEP/COS, 1 JDMF, 6 EU WC, 2 KDMF, 14 NDC API, 14 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports, FDF Imports

INTERMEDIATES

3 Suppliers

3 Suppliers

DOSSIERs // Finished Dosage Formulations

159 Dossiers, 113 FDA Orange Book, 22 Europe, 10 Canada, 6 South Africa, 8 Listed Dossiers

DRUG PRODUCT COMPOSITION

TABLET;ORAL - 120MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET;ORAL - 80MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, EXTENDED RELEASE;ORAL - 120MG
TABLET, EXTENDED RELEASE;ORAL - 180MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, EXTENDED RELEASE;ORAL - 240MG
CAPSULE, EXTENDED RELEASE;ORAL - 120MG
CAPSULE, EXTENDED RELEASE;ORAL - 180MG
CAPSULE, EXTENDED RELEASE;ORAL - 240MG
CAPSULE, EXTENDED RELEASE;ORAL - 360MG
CAPSULE, EXTENDED RELEASE;ORAL - 100MG
CAPSULE, EXTENDED RELEASE;ORAL - 200MG
CAPSULE, EXTENDED RELEASE;ORAL - 300MG

RELATED EXCIPIENT COMPANIES

Suppliers, 38 Kerry, 34 BASF, 23 Roquette, 16 Ideal Cures Pvt Ltd, 16 Corel Pharma Chem, 14 Seppic, 13 Gangwal Chemicals, 13 Microlex e.U, 12 Sigachi Industries, 11 Gangwal Healthcare, 11 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 10 Actylis, 7 DFE Pharma, 6 SPI Pharma, 6 Lonza Capsugel, 6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 5 Prachin Chemical, 5 Pharmatrans-Sanaq, 5 Nanjing Well Pharmaceutical, 5 Boai NKY Pharmaceuticals Ltd, 4 Vasa Pharmachem, 4 ACG Worldwide, 4 Ingredion Pharma Solutions, 4 Kima Chemical, 3 The Dow Chemical Company, 3 Jai Radhe Sales, 3 Evonik, 3 Alcedo Pharmachem, 3 DKSH, 2 Seqens, 2 Finar, 2 Qualicaps, 2 Rochem International Inc, 2 Nomisma Healthcare, 2 Ulanqab Kema New Material, 1 Aeon Procare, 1 Vertellus, 1 Bioplus Life Sciences, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Doshion Polyscience, 1 Clariant, 1 NEWEDGE Overseas, 1 Chynops Pharma, 1 Pharm-RX Chemical, 1 Nanjing Bold Chemical, 1 Pfanstiehl, 1 Minakem

EXCIPIENTS BY APPLICATIONS

75 Coating Systems & Additives, 73 Fillers, Diluents & Binders, 49 Controlled & Modified Release, 47 Disintegrants & Superdisintegrants, 39 Direct Compression, 32 Solubilizers, 31 Granulation, 27 Thickeners and Stabilizers, 22 Taste Masking, 21 Lubricants & Glidants, 17 Parenteral, 16 Film Formers & Plasticizers, 15 Topical, 13 Co-Processed Excipients, 12 Chewable & Orodispersible Aids, 9 Empty Capsules, 7 Emulsifying Agents, 6 API Stability Enhancers, 5 Rheology Modifiers, 4 Vegetarian Capsules, 3 Surfactant & Foaming Agents, 2 Coloring Agents

GLOBAL SALES INFORMATION

52 US Medicaid Prescriptions, 36 Finished Drug Prices

MARKET PLACE

13 APIs, 1 DOSSIERS // FDF

PATENTS

4 Health Canada Patents

4 Health Canada Patents

ANALYTICAL SOLUTION(s)

4 EDQM Standards, 1 USP Standards, 1 Other Ref. Standards

DIGITAL CONTENT

18 News

18 News

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

113

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

735.00

Annual Reports

FDF Market Place

EXCIPIENTS

311

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: 152-11-4, Verapamil hcl, Manidon, Cordilox, Calcan hydrochloride, Verelan

Molecular Formula

C₂₇H₃₉ClN₂O₄

Molecular Weight

491.1 g/mol

InChI Key

DOQPXTMNIUCOSY-UHFFFAOYSA-N

FDA UNII

V3888OEY5R

A calcium channel blocker that is a class IV anti-arrhythmia agent.

1 2D Structure

NCGC00024710-03

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride

2.1.2 InChI

InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H

2.1.3 InChI Key

DOQPXTMNIUCOSY-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl

2.2 Other Identifiers

2.2.1 UNII

V3888OEY5R

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Calan

2. Cordilox

3. Dexverapamil

4. Falicard

5. Finoptin

6. Hydrochloride, Verapamil

7. Iproveratril

8. Isoptin

9. Isoptine

10. Izoptin

11. Lekoptin

12. Verapamil

2.3.2 Depositor-Supplied Synonyms

1. 152-11-4

2. Verapamil Hcl

3. Manidon

4. Cordilox

5. Calcan Hydrochloride

6. Verelan

7. (+/-)-verapamil Hydrochloride

8. Cardibeltin

9. Isoptin

10. Calan

11. 23313-68-0

12. Verapamil (hydrochloride)

13. Cardiabeltin

14. Cardioprotect

15. Veroptinstada

16. Berkatens

17. Calaptin

18. Cardiagutt

19. Caveril

20. Civicor

21. Coraver

22. Corpamil

23. Dignover

24. Durasoptin

25. Geangin

26. Harteze

27. Hexasoptin

28. Hormitol

29. Ikapress

30. Inselon

31. Isoptino

32. Izoptin

33. Jenapamil

34. Lodixal

35. Magotiron

36. Praecicor

37. Robatelan

38. Vasomil

39. Vasopten

40. Verabeta

41. Veracor

42. Verahexal

43. Veraloc

44. Veramex

45. Veramil

46. Verapin

47. Verasal

48. Verasifar

49. Veratensin

50. Verdilac

51. Vetrimil

52. Akilen

53. Elthon

54. Flamon

55. Ikacor

56. Quasar

57. Univer

58. Univex

59. Vortac

60. Anpec

61. Ormil

62. Rapam

63. Verapamil Ebewe

64. Verapamil Riker

65. Verapamil Verla

66. Civicor Retard

67. Isoptin Retard

68. Manidon Retard

69. Vera-sanorania

70. Verapamil Acis

71. Verapamil Atid

72. Novo-veramil

73. Verapamil Basics

74. Verapamil Nordic

75. Verapamil-abz

76. Novapamyl Lp

77. Verapamil Al

78. Verapamil Nm

79. Verapamil Pb

80. Verapamil Sr

81. Verapamyl Hydrochloride

82. Apo-verap

83. Cordilox Sr

84. Dilacoran Hta

85. Veracaps Sr

86. Verapamil Msd

87. Arpamyl Lp

88. Hexasoptin Retard

89. Isoptin Sr

90. Nu-verap

91. Verapamil Henning

92. Verelan Sr

93. Covera-hs

94. Covera

95. Calan Sr

96. Verapamil Injection

97. Verapamil Nm Pharma

98. Calaptin 240 Sr

99. Verapress 240 Sr

100. Mfcd00055208

101. 5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile Hydrochloride

102. Nsc-272366

103. Nsc-657799

104. Mls000069485

105. V3888oey5r

106. Nsc657799

107. Lu-20175

108. Smr000059109

109. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Hydrochloride

110. 5-[n-(3,4-dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Hydrochloride

111. ( Inverted Exclamation Marka)-verapamil Hydrochlorid

112. Verapamil Chloridrate

113. D-365 Hydrochloride

114. Iproveratril Hydrochloride

115. 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride

116. 5-[(3,4-dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxy Phenyl)-2-isopropylvaleronitrile Hydrochloride

117. Nsc272366

118. Sr-01000000050

119. Einecs 205-800-5

120. Nsc 272366

121. Unii-v3888oey5r

122. Lu 20175

123. C27h38n2o4.hcl

124. Verapamil, Hcl

125. Verapamil-d7 Hcl

126. Prestwick_440

127. Vasolan (tn)

128. Verelan (tn)

129. Covera-hs (tn)

130. Calan (tn)

131. Isotopin Hydrochloride

132. Verapamil Hydrochloride [usan:usp:jan]

133. Verapamili Hydrochloridum

134. Opera_id_1210

135. ()-verapamil Hydrochlorid

136. Cas-152-11-4

137. (y)-verapamil Hydrochloride

138. (?)-verapamil Hydrochloride

139. Chembl1280

140. Dsstox_cid_14095

141. Dsstox_rid_79114

142. Verapamil Hydrochloride,(s)

143. Dsstox_gsid_34095

144. Schembl33296

145. 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Monohydrochloride

146. Benzeneacetonitrile, Alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-, Monohydrochloride

147. Mls001055442

148. Mls002222213

149. (+-)-verapamil Hydrochloride

150. Spectrum2300307

151. Dtxsid2034095

152. Hms1568m04

153. Hms1922j16

154. Pharmakon1600-02300307

155. Bcp06465

156. Hy-a0064

157. Tox21_201180

158. Tox21_501237

159. Verapamil Hydrochloride [mi]

160. Ccg-39491

161. Nsc759589

162. S4202

163. Verapamil Hydrochloride (jp17/usp)

164. Verapamil Hydrochloride [jan]

165. Verapamil Hydrochloride [hsdb]

166. Verapamil Hydrochloride [usan]

167. Akos005267117

168. Ac-8483

169. Cs-1685

170. Lp01237

171. Nsc-759589

172. Verapamil Hydrochloride [mart.]

173. Verapamil Hydrochloride [vandf]

174. Verapamil Hydrochloride [usp-rs]

175. Verapamil Hydrochloride [who-dd]

176. Verapamil Hydrochloride [who-ip]

177. Ncgc00024710-03

178. Ncgc00094479-01

179. Ncgc00094479-02

180. Ncgc00094479-03

181. Ncgc00094479-04

182. Ncgc00094479-05

183. Ncgc00258732-01

184. Ncgc00261922-01

185. (+-)-5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Monohydrochloride

186. 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile Hydrochloride

187. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]methylamino}-2-(methy Lethyl)pentanenitrile, Chloride

188. Ac-16228

189. As-16018

190. Benzeneacetonitrile, Alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-, Monohydrochloride, (+-)-

191. Bv164516

192. Sy073165

193. Valeronitrile, 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropyl-, Monohydrochloride

194. Eu-0101237

195. Ft-0603360

196. Ft-0630593

197. Ft-0655647

198. Ft-0675800

199. Sw196662-4

200. V0118

201. Verapamil Hydrochloride [ep Impurity]

202. Verapamil Hydrochloride [orange Book]

203. Tarka Component Verapamil Hydrochloride

204. Verapamil Hydrochloride [ep Monograph]

205. D00619

206. D78147

207. D88195

208. V 4629

209. Verapamil Hydrochloride [usp Monograph]

210. ( Inverted Question Mark)-verapamil Hydrochloride

211. Verapamil Hydrochloride Component Of Tarka

212. Verapamili Hydrochloridum [who-ip Latin]

213. 152v114

214. A816666

215. Q-201923

216. Sr-01000000050-2

217. Sr-01000000050-4

218. (+/-)-verapamil, Hydrochloride - Cas 152-11-4

219. Q27291481

220. Sr-01000000050-11

221. Z2210978706

222. (+/-)-verapamil Hydrochloride, >=99% (titration), Powder

223. Verapamil Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

224. Verapamil Hydrochloride, European Pharmacopoeia (ep) Reference Standard

225. Verapamil Hydrochloride, United States Pharmacopeia (usp) Reference Standard

226. (+/-)-5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Monohydrochloride

227. (+/-)-verapamil Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

228. 2-(3,4-dimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)-ethyl](methyl)amino]-2-isopropylpentanenitrile Hydrochloride

229. 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-propan-2-yl-pentanenitrile Hydrochloride

230. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-isopropylpentanenitrile Hydrochloride

231. 5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrilehydrochloride

232. 5-[(3,4-dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Hydrochloride

233. Alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl) Benzeneacetonitrile Hydrochloride

234. Alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile Hydrochloride (1:1)

235. Benzeneacetonitrile, .alpha.-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-.alpha.-(1-methylethyl)-, Monohydrochloride, (+/-)-

236. Benzeneacetonitrile,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-.alpha.-(1-methylethyl)-, Monohydrochloride

237. Verapamil Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₂₇H₃₉ClN₂O₄
Molecular Weight	491.1 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	13
Exact Mass	490.2598354 g/mol
Monoisotopic Mass	490.2598354 g/mol
Topological Polar Surface Area	64 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	606
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Verapamil hydrochloride
Drug Label	Verelan (verapamil hydrochloride capsules) is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist). Verelan is available for oral administration as a 360 mg hard gelatin capsule (lavender cap/yellow body), a 240 mg hard g...
Active Ingredient	Verapamil hydrochloride
Dosage Form	Tablet, extended release; Tablet; Injectable; Capsule, extended release
Route	Injection; Oral
Strength	180mg; 200mg; 2.5mg/ml; 120mg; 300mg; 100mg; 80mg; 40mg; 240mg
Market Status	Prescription
Company	Hospira; Apotex; Sun Pharm Inds; Par Pharm; Watson Labs; Glenmark Generics; Ivax Sub Teva Pharms; Mylan; Heritage Pharms

2 of 2
Drug Name	Verapamil hydrochloride
Drug Label	Verelan (verapamil hydrochloride capsules) is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist). Verelan is available for oral administration as a 360 mg hard gelatin capsule (lavender cap/yellow body), a 240 mg hard g...
Active Ingredient	Verapamil hydrochloride
Dosage Form	Tablet, extended release; Tablet; Injectable; Capsule, extended release
Route	Injection; Oral
Strength	180mg; 200mg; 2.5mg/ml; 120mg; 300mg; 100mg; 80mg; 40mg; 240mg
Market Status	Prescription
Company	Hospira; Apotex; Sun Pharm Inds; Par Pharm; Watson Labs; Glenmark Generics; Ivax Sub Teva Pharms; Mylan; Heritage Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Calcium Channel Blockers

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Calcium Channel Blocker [EPC]; Cytochrome P450 3A Inhibitors [MoA]; Cytochrome P450 3A4 Inhibitors [MoA]; P-Glycoprotein Inhibitors [MoA]; Calcium Channel Antagonists [MoA]