Find Nalbuphine Hydrochloride manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Nubain, Nalbuphine hcl, 23277-43-2, Nalbuphine hydrochloride [usan], En-2234a, Nalbufine hydrochloride
Molecular Formula
C21H28ClNO4
Molecular Weight
393.9  g/mol
InChI Key
YZLZPSJXMWGIFH-BCXQGASESA-N
FDA UNII
ZU4275277R

Nalbuphine Hydrochloride
A narcotic used as a pain medication. It appears to be an agonist at KAPPA RECEPTORS and an antagonist or partial agonist at MU RECEPTORS.
1 2D Structure

Nalbuphine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4R,4aS,7S,7aR,12bS)-3-(cyclobutylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol;hydrochloride
2.1.2 InChI
InChI=1S/C21H27NO4.ClH/c23-14-5-4-13-10-16-21(25)7-6-15(24)19-20(21,17(13)18(14)26-19)8-9-22(16)11-12-2-1-3-12;/h4-5,12,15-16,19,23-25H,1-3,6-11H2;1H/t15-,16+,19-,20-,21+;/m0./s1
2.1.3 InChI Key
YZLZPSJXMWGIFH-BCXQGASESA-N
2.1.4 Canonical SMILES
C1CC(C1)CN2CCC34C5C(CCC3(C2CC6=C4C(=C(C=C6)O)O5)O)O.Cl
2.1.5 Isomeric SMILES
C1CC(C1)CN2CC[C@]34[C@@H]5[C@H](CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O)O.Cl
2.2 Other Identifiers
2.2.1 UNII
ZU4275277R
2.3 Synonyms
2.3.1 MeSH Synonyms

1. En 2234a

2. En-2234a

3. En2234a

4. Nalbuphine

5. Nalbuphine Serb

6. Nubain

2.3.2 Depositor-Supplied Synonyms

1. Nubain

2. Nalbuphine Hcl

3. 23277-43-2

4. Nalbuphine Hydrochloride [usan]

5. En-2234a

6. Nalbufine Hydrochloride

7. Nsc-757829

8. Zu4275277r

9. (4r,4as,7s,7ar,12bs)-3-(cyclobutylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol;hydrochloride

10. Nalbuphine Hydrochloride (usan)

11. Chebi:7455

12. Nalbufina Clorhidrato [spanish]

13. En 2234a

14. Einecs 245-549-9

15. Nalbuphinehydrochloride

16. Unii-zu4275277r

17. Prestwick_344

18. Nubain (tn)

19. 17-(cyclobutylmethyl)-4,5alpha-epoxymorphinan-3,6alpha,14-triol Hydrochloride

20. (5alpha,6alpha)-17-(cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol Hydrochloride

21. Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, Hydrochloride, (5-alpha,6-alpha)-

22. Schembl41123

23. Mls002154202

24. Chembl1201132

25. Dtxsid20177844

26. Hms1568g18

27. Nalbuphine Hydrochloride [mi]

28. Ccg-220118

29. Nsc 757829

30. Pw-4142

31. Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, Hydrochloride, (5alpha,6alpha)-

32. Morphinan-3,6-alpha,14-triol, 17-(cyclobutylmethyl)-4,5-alpha-epoxy-, Hydrochloride

33. Nalbuphine Hydrochloride [mart.]

34. Nalbuphine Hydrochloride [vandf]

35. Nalbuphine Hydrochloride [who-dd]

36. Bn161328

37. Smr001233488

38. Nalbuphine Hydrochloride [orange Book]

39. D00843

40. E98629

41. Q27107499

42. (-)-17-(cyclobutylmethyl)- 4,5a-epoxymorphinan- 3,6a,14-triol Hydrochloride

43. 17-(cyclobutylmethyl)-4,5.alpha.-epoxymorphinan-3,6.alpha.,14-triol Hydrochloride

44. Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, Hydrochloride, (5.alpha.,6.alpha.)-

45. Nalbuphine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 393.9 g/mol
Molecular Formula C21H28ClNO4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass393.1706861 g/mol
Monoisotopic Mass393.1706861 g/mol
Topological Polar Surface Area73.2 Ų
Heavy Atom Count27
Formal Charge0
Complexity597
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameNalbuphine hydrochloride
Drug LabelAmpulFliptop VialProtect from light.Rx OnlyNalbuphine hydrochloride is a synthetic opioid agonist-antagonist analgesic of the phenanthrene series. It is chemically related to both the widely used opioid antagonist, naloxone, and the potent opioid ana...
Active IngredientNalbuphine hydrochloride
Dosage FormInjectable
RouteInjection
Strength20mg/ml; 10mg/ml
Market StatusPrescription
CompanyHospira

2 of 2  
Drug NameNalbuphine hydrochloride
Drug LabelAmpulFliptop VialProtect from light.Rx OnlyNalbuphine hydrochloride is a synthetic opioid agonist-antagonist analgesic of the phenanthrene series. It is chemically related to both the widely used opioid antagonist, naloxone, and the potent opioid ana...
Active IngredientNalbuphine hydrochloride
Dosage FormInjectable
RouteInjection
Strength20mg/ml; 10mg/ml
Market StatusPrescription
CompanyHospira

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Analgesics, Opioid

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Opioid Agonist/Antagonist [EPC]; Partial Opioid Agonists [MoA]; Competitive Opioid Antagonists [MoA]

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ABOUT THIS PAGE

Looking for 23277-43-2 / Nalbuphine Hydrochloride API manufacturers, exporters & distributors?

Nalbuphine Hydrochloride manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Nalbuphine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Nalbuphine Hydrochloride manufacturer or Nalbuphine Hydrochloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Nalbuphine Hydrochloride manufacturer or Nalbuphine Hydrochloride supplier.

PharmaCompass also assists you with knowing the Nalbuphine Hydrochloride API Price utilized in the formulation of products. Nalbuphine Hydrochloride API Price is not always fixed or binding as the Nalbuphine Hydrochloride Price is obtained through a variety of data sources. The Nalbuphine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Nalbuphine Hydrochloride

Synonyms

Nubain, Nalbuphine hcl, 23277-43-2, Nalbuphine hydrochloride [usan], En-2234a, Nalbufine hydrochloride

Cas Number

23277-43-2

Unique Ingredient Identifier (UNII)

ZU4275277R

About Nalbuphine Hydrochloride

A narcotic used as a pain medication. It appears to be an agonist at KAPPA RECEPTORS and an antagonist or partial agonist at MU RECEPTORS.

Nalbuphine HCL Manufacturers

A Nalbuphine HCL manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nalbuphine HCL, including repackagers and relabelers. The FDA regulates Nalbuphine HCL manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nalbuphine HCL API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Nalbuphine HCL manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Nalbuphine HCL Suppliers

A Nalbuphine HCL supplier is an individual or a company that provides Nalbuphine HCL active pharmaceutical ingredient (API) or Nalbuphine HCL finished formulations upon request. The Nalbuphine HCL suppliers may include Nalbuphine HCL API manufacturers, exporters, distributors and traders.

click here to find a list of Nalbuphine HCL suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Nalbuphine HCL USDMF

A Nalbuphine HCL DMF (Drug Master File) is a document detailing the whole manufacturing process of Nalbuphine HCL active pharmaceutical ingredient (API) in detail. Different forms of Nalbuphine HCL DMFs exist exist since differing nations have different regulations, such as Nalbuphine HCL USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Nalbuphine HCL DMF submitted to regulatory agencies in the US is known as a USDMF. Nalbuphine HCL USDMF includes data on Nalbuphine HCL's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Nalbuphine HCL USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Nalbuphine HCL suppliers with USDMF on PharmaCompass.

Nalbuphine HCL WC

A Nalbuphine HCL written confirmation (Nalbuphine HCL WC) is an official document issued by a regulatory agency to a Nalbuphine HCL manufacturer, verifying that the manufacturing facility of a Nalbuphine HCL active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Nalbuphine HCL APIs or Nalbuphine HCL finished pharmaceutical products to another nation, regulatory agencies frequently require a Nalbuphine HCL WC (written confirmation) as part of the regulatory process.

click here to find a list of Nalbuphine HCL suppliers with Written Confirmation (WC) on PharmaCompass.

Nalbuphine HCL NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Nalbuphine HCL as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Nalbuphine HCL API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Nalbuphine HCL as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Nalbuphine HCL and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Nalbuphine HCL NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Nalbuphine HCL suppliers with NDC on PharmaCompass.

Nalbuphine HCL GMP

Nalbuphine HCL Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Nalbuphine HCL GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nalbuphine HCL GMP manufacturer or Nalbuphine HCL GMP API supplier for your needs.

Nalbuphine HCL CoA

A Nalbuphine HCL CoA (Certificate of Analysis) is a formal document that attests to Nalbuphine HCL's compliance with Nalbuphine HCL specifications and serves as a tool for batch-level quality control.

Nalbuphine HCL CoA mostly includes findings from lab analyses of a specific batch. For each Nalbuphine HCL CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Nalbuphine HCL may be tested according to a variety of international standards, such as European Pharmacopoeia (Nalbuphine HCL EP), Nalbuphine HCL JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nalbuphine HCL USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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