menu
    • menu

    Find NAFTIFINE HCL manufacturers, exporters & distributors on PharmaCompass

    Client Email Product
    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    Virtual Booth

    Contact Supplier

    FAMAR CDMO- From early development to commercial manufacturing.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-09-09

    Virtual Booth

    Contact Supplier

    Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients & provides custom-made solutions.

    Access Virtual Booth

    Contact Supplier

    Veranova: A CDMO that manages complexity with confidence.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-09-09

    Virtual Booth

    Contact Supplier

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

    DRUG PRODUCT COMPOSITIONS

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    DIGITAL CONTENT

    GLOBAL SALES INFORMATION

    MARKET PLACE

    PATENTS & EXCLUSIVITIES

    REF. STANDARDS & IMPURITIES

    PharmaCompass

    Synopsis

    Product SearchProduct Search

    Synopsis

    ACTIVE PHARMA INGREDIENTS

    16

    API Suppliers

    API Suppliers

    8

    USDMF

    US DMFs Filed

    0

    CEP/COS

    CEP/COS Certifications

    0

    JDMF

    JDMFs Filed

    2

    EU WC

    EU WC

    1

    KDMF

    KDMF

    3

    NDC API

    NDC API

    0

    VMF

    NDC API

    9

    Listed Suppliers

    Other Suppliers

    API REF. PRICE (USD/KG)

    $
    $ 411

    MARKET PLACE

    14

    API

    0

    FDF

    3INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

    18

    FDF Dossiers

    FDF Dossiers

    10

    FDA Orange Book

    FDA (Orange Book)

    6

    Europe

    Europe

    0

    Canada

    Canada

    0

    Australia

    Australia

    0

    South Africa

    South Africa

    2

    Listed Dossiers

    Listed Dossiers

    0 DRUGS IN DEVELOPMENT

    FDF DossiersDRUG PRODUCT COMPOSITIONS

    REF. STANDARDS OR IMPURITIES

    0

    EDQM

    1

    USP

    0

    JP

    1

    Others

    PATENTS & EXCLUSIVITIES

    6

    US Patents

    0

    US Exclusivities

    0

    Health Canada Patents

    DIGITAL CONTENT

    0

    Data Compilation #PharmaFlow

    0

    Stock Recap #PipelineProspector

    0

    Weekly News Recap #Phispers

    3

    News #PharmaBuzz

    GLOBAL SALES INFORMATION

    US Medicaid

    10,129,720

    Annual Reports

    NA

    Finished Drug Prices

    Listed Dossiers

    47 RELATED EXCIPIENT COMPANIES

    101EXCIPIENTS BY APPLICATIONS

    Chemistry

    Click the arrow to open the dropdown
    read-moreClick the button for full data set
    read-moreClick the button for full data set
    Also known as: 65473-14-5, Naftifine hcl, Naftin, Exoderil, Naftifungin, Naftifine, hcl
    Molecular Formula
    C21H22ClN
    Molecular Weight
    323.9  g/mol
    InChI Key
    OLUNPKFOFGZHRT-YGCVIUNWSA-N
    FDA UNII
    25UR9N9041
    NAFTIFINE HCL
    Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its effect is unknown, it appears to selectively inhibit the enzyme squalene 2,3-epoxidase, thereby inhibiting the biosynthesis of sterol. This results in a decreased amount of sterols, especially ergosterol which is the primary fungal membrane sterol, and a corresponding accumulation of squalene in fungal cells. Naftifine hydrochloride can be fungicidal as well as fungistatic to yeasts depending on the concentration and the organisms involved.
    1 2D Structure

    NAFTIFINE HCL

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine;hydrochloride
    2.1.2 InChI
    InChI=1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
    2.1.3 InChI Key
    OLUNPKFOFGZHRT-YGCVIUNWSA-N
    2.1.4 Canonical SMILES
    CN(CC=CC1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32.Cl
    2.1.5 Isomeric SMILES
    CN(C/C=C/C1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    25UR9N9041
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. N-cinnamyl-n-methyl-1-naphthalenemethylamine Hydrochloride

    2. Naftifin

    3. Naftifine

    4. Naftifine Hydrochloride, (e)-isomer

    2.3.2 Depositor-Supplied Synonyms

    1. 65473-14-5

    2. Naftifine Hcl

    3. Naftin

    4. Exoderil

    5. Naftifungin

    6. Naftifine, Hcl

    7. Aw 105-843

    8. Naftifine (hydrochloride)

    9. (e)-n-methyl-n-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine Hydrochloride

    10. Aw 105843

    11. Nsc-760068

    12. Naft900

    13. Chebi:7452

    14. Naft-900

    15. Naftifin

    16. 25ur9n9041

    17. N-trans-cinnamyl-n-methyl-(1-naphthylmethyl)amine Hydrochloride

    18. Dsstox_cid_25496

    19. Dsstox_rid_80915

    20. Dsstox_gsid_45496

    21. Aw-105-843

    22. 65473-14-5 (hcl); 65472-88-0 (free Base).

    23. (e)-n-methyl-n-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine;hydrochloride

    24. Naftifinehydrochloride

    25. Naftifine Hydrochloride [usan]

    26. Suadian

    27. Sn 105843

    28. Unii-25ur9n9041

    29. (e)-naftifine

    30. Naftin Hydrochloride

    31. Naftifine Hydrochloride [usan:usp]

    32. Mfcd00059047

    33. Naftin (tn)

    34. (e)-n-methyl-n-(1-naphthylmethyl)-3-phenyl-prop-2-en-1-amine

    35. (e)-n-cinnamyl-n-methyl-1-naphthalenemethylamine Hydrochloride

    36. Ncgc00016908-01

    37. (e)-n-methyl-n-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine- Hydrochloride

    38. Cas-65473-14-5

    39. Surecn1649698

    40. Schembl41356

    41. Mls002154136

    42. Naftifine Hydrochloride ,(s)

    43. Naftifine Hydrochloride (usp)

    44. Naft-600

    45. Schembl4932462

    46. Chembl1200493

    47. Dtxsid2045496

    48. Hy-b0518a

    49. Hms1571e08

    50. Pharmakon1600-01505446

    51. Bcp07446

    52. Naftifine Hydrochloride [mi]

    53. Tox21_110677

    54. Nsc760068

    55. S3156

    56. Akos015895211

    57. Tox21_110677_1

    58. Ac-1120

    59. Ccg-213447

    60. H72n880

    61. Naftifine Hydrochloride [mart.]

    62. Naftifine Hydrochloride [vandf]

    63. Nsc 760068

    64. 1-naphthalenemethanamine, N-methyl-n-(3-phenyl-2-propenyl)-, Hydrochloride, (e)-

    65. 1-naphthalenemethanamine, N-methyl-n-[(2e)-3-phenyl-2-propenyl]-,hydrochloride

    66. Naftifine Hydrochloride [usp-rs]

    67. Naftifine Hydrochloride [who-dd]

    68. Ncgc00179332-03

    69. As-13296

    70. Smr001233443

    71. Sn-105843

    72. C1162

    73. Naftifine Hydrochloride [orange Book]

    74. Naftifine Hydrochloride [usp Impurity]

    75. C08072

    76. D00883

    77. Naftifine Hydrochloride [usp Monograph]

    78. A835130

    79. Sr-01000838853

    80. Sr-01000838853-2

    81. Naftifine Hydrochloride 100 Microg/ml In Acetonitrile

    82. Q27107497

    83. (e)-n-cinnamyl-n-methyl(1-naphthylmethyl)amine Hydrochloride

    84. N-methyl-n-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine Hydrochloride

    85. Naftifine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    86. (e)-n-methyl-n-(1-naphthalenylmethyl)-3-phenyl-2-propen-1-amine Hydrochloride

    87. (e)-n-methyl-n-(3-phenyl-2-propenyl)-1-naphthalenemethanamine Hydrochloride

    88. (e)-n-methyl-n-(naphthalen-1-ylmethyl)-3-phenyl-prop-2-en-1-amine Hydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 323.9 g/mol
    Molecular Formula C21H22ClN
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count5
    Exact Mass323.1440774 g/mol
    Monoisotopic Mass323.1440774 g/mol
    Topological Polar Surface Area3.2 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity342
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameNaftin
    PubMed HealthNaftifine (On the skin)
    Drug ClassesAntifungal
    Drug LabelNaftin Cream, 1% contains the synthetic, broad-spectrum, antifungal agent naftifine hydrochloride. Naftin Cream, 1% is for topical use only....
    Active IngredientNaftifine hydrochloride
    Dosage FormCream; Gel
    RouteTopical
    Strength1%; 2%
    Market StatusPrescription
    CompanyMerz Pharms

    2 of 2  
    Drug NameNaftin
    PubMed HealthNaftifine (On the skin)
    Drug ClassesAntifungal
    Drug LabelNaftin Cream, 1% contains the synthetic, broad-spectrum, antifungal agent naftifine hydrochloride. Naftin Cream, 1% is for topical use only....
    Active IngredientNaftifine hydrochloride
    Dosage FormCream; Gel
    RouteTopical
    Strength1%; 2%
    Market StatusPrescription
    CompanyMerz Pharms

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antifungal Agents

    Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Allylamine [CS]; Allylamine Antifungal [EPC]

    DRUG PRODUCT COMPOSITIONS

    Do you need Business Intel? Ask us

    DOSAGE - GEL;TOPICAL - 1%

    USFDA APPLICATION NUMBER - 19356

    read-more

    DOSAGE - CREAM;TOPICAL - 1% **Federal Registe...DOSAGE - CREAM;TOPICAL - 1% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 19599

    read-more

    DOSAGE - CREAM;TOPICAL - 2%

    USFDA APPLICATION NUMBER - 19599

    read-more

    DOSAGE - GEL;TOPICAL - 2%

    USFDA APPLICATION NUMBER - 204286

    read-more

    Related Excipient Companies

    Upload your portfolio for free, ask us

    Excipients by Applications

    Click here to find the perfect excipient manufacturers by their capabilities

    Topical

    read-more
    read-more

    Solubilizers

    read-more
    read-more

    Parenteral

    read-more
    read-more

    Emulsifying Agents

    read-more
    read-more

    Thickeners and Stabilizers

    read-more
    read-more

    Surfactant & Foaming Agents

    read-more
    read-more

    Rheology Modifiers

    read-more
    read-more

    Film Formers & Plasticizers

    read-more
    read-more

    Direct Compression

    read-more
    read-more

    API Stability Enhancers

    read-more
    read-more

    Controlled & Modified Release

    read-more
    read-more

    Granulation

    read-more
    read-more

    Lubricants & Glidants

    read-more
    read-more

    Co-Processed Excipients

    read-more
    read-more

    Digital Content read-more

    Create Content with PharmaCompass, ask us

    NEWS #PharmaBuzz

    read-more
    read-more

    Global Sales Information

    Do you need Business Intel? Ask us

    Market Place

    Do you need sourcing support? Ask us

    Patents & EXCLUSIVITIES

    Check the patents & exclusivity for this product

    REF. STANDARDS & IMPURITIES

    Upload your portfolio for free, ask us

    USP

    read-more
    read-more

    ABOUT THIS PAGE

    Ask Us for Pharmaceutical Supplier and Partner
    Ask Us, Find A Supplier / Partner
    No Commissions, No Strings Attached, Get Connected for FREE

    What are you looking for?

    How can we help you?

    The request can't be empty

    Please read our Privacy Policy carefully

    You must agree to the privacy policy

    The name can't be empty
    The company can't be empty.
    The email can't be empty Please enter a valid email.
    The mobile can't be empty

    Market Place

    Market Place

    PharmaCompass

    Home

    Market Place

    Menu

    Post Enquiry

    Post Enquiry

    Market Place

    Market Place

    Search