Nafarelin Acetate

Synopsis, Chemistry

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Also known as: Nafarelin acetate hydrate (jan), Synarel (tn), Chebi:7446, Bcp19032, Ft-0642036, D00990

Molecular Formula

C₆₈H₈₉N₁₇O₁₆

Molecular Weight

1400.5 g/mol

InChI Key

FSBTYDWUUWLHBD-UHFFFAOYSA-N

1 2D Structure

Nafarelin Acetate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

acetic acid;N-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide;hydrate

2.1.2 InChI

InChI=1S/C66H83N17O13.C2H4O2.H2O/c1-36(2)25-48(58(89)76-47(13-7-23-71-66(68)69)65(96)83-24-8-14-54(83)64(95)73-33-55(67)86)77-60(91)50(28-38-15-18-39-9-3-4-10-40(39)26-38)78-59(90)49(27-37-16-19-43(85)20-17-37)79-63(94)53(34-84)82-61(92)51(29-41-31-72-45-12-6-5-11-44(41)45)80-62(93)52(30-42-32-70-35-74-42)81-57(88)46-21-22-56(87)75-46;1-2(3)4;/h3-6,9-12,15-20,26,31-32,35-36,46-54,72,84-85H,7-8,13-14,21-25,27-30,33-34H2,1-2H3,(H2,67,86)(H,70,74)(H,73,95)(H,75,87)(H,76,89)(H,77,91)(H,78,90)(H,79,94)(H,80,93)(H,81,88)(H,82,92)(H4,68,69,71);1H3,(H,3,4);1H2

2.1.3 InChI Key

FSBTYDWUUWLHBD-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)C(CC2=CC3=CC=CC=C3C=C2)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8.CC(=O)O.O

2.2 Synonyms

2.2.1 Depositor-Supplied Synonyms

1. Nafarelin Acetate Hydrate (jan)

2. Synarel (tn)

3. Chebi:7446

4. Bcp19032

5. Ft-0642036

6. D00990

7. Rs 94991 298;rs-94991-298;rs94991298

2.3 Create Date

2008-12-10

3 Chemical and Physical Properties

Molecular Formula	C₆₈H₈₉N₁₇O₁₆
Molecular Weight	1400.5 g/mol
Hydrogen Bond Donor Count	18
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	33
Exact Mass	1399.66731982 g/mol
Monoisotopic Mass	1399.66731982 g/mol
Topological Polar Surface Area	513 Å²
Heavy Atom Count	101
Formal Charge	0
Complexity	2760
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	9
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Synarel
PubMed Health	Nafarelin (Into the nose)
Drug Classes	Endocrine-Metabolic Agent
Drug Label	SYNAREL (nafarelin acetate) Nasal Solution is intended for administration as a spray to the nasal mucosa. Nafarelin acetate, the active component of SYNAREL Nasal Solution, is a decapeptide with the chemical name: 5-oxo-L-prolyl-L-histidyl-L-tryptoph...
Active Ingredient	Nafarelin acetate
Dosage Form	Spray, metered
Route	Nasal
Strength	eq 0.2mg base/spray
Market Status	Prescription
Company	Gd Searle

2 of 2
Drug Name	Synarel
PubMed Health	Nafarelin (Into the nose)
Drug Classes	Endocrine-Metabolic Agent
Drug Label	SYNAREL (nafarelin acetate) Nasal Solution is intended for administration as a spray to the nasal mucosa. Nafarelin acetate, the active component of SYNAREL Nasal Solution, is a decapeptide with the chemical name: 5-oxo-L-prolyl-L-histidyl-L-tryptoph...
Active Ingredient	Nafarelin acetate
Dosage Form	Spray, metered
Route	Nasal
Strength	eq 0.2mg base/spray
Market Status	Prescription
Company	Gd Searle