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Muzolimine

Muzolimine

Synopsis, Chemistry

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Also known as: 55294-15-0, Edrul, Muzolimina, Bay g 2821, Bay-g-2821, Bay-g 2821; edrul

Molecular Formula

C₁₁H₁₁Cl₂N₃O

Molecular Weight

272.13 g/mol

InChI Key

RLWRMIYXDPXIEX-UHFFFAOYSA-N

FDA UNII

07Z36289ZX

A pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide because of severe neurological effects.

1 2D Structure

Muzolimine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one

2.1.2 InChI

InChI=1S/C11H11Cl2N3O/c1-6(16-11(17)5-10(14)15-16)7-2-3-8(12)9(13)4-7/h2-4,6H,5H2,1H3,(H2,14,15)

2.1.3 InChI Key

RLWRMIYXDPXIEX-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C1=CC(=C(C=C1)Cl)Cl)N2C(=O)CC(=N2)N

2.2 Other Identifiers

2.2.1 UNII

07Z36289ZX

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Bay G 2821

2. G 2821, Bay

2.3.2 Depositor-Supplied Synonyms

1. 55294-15-0

2. Edrul

3. Muzolimina

4. Bay G 2821

5. Bay-g-2821

6. Bay-g 2821; Edrul

7. 3-amino-1-(1-(3,4-dichlorophenyl)ethyl)-1h-pyrazol-5(4h)-one

8. Bay-g 2821

9. 07z36289zx

10. Muzolimina [spanish]

11. 3h-pyrazol-3-one, 5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-2,4-dihydro-

12. 3h-pyrazol-3-one, 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-

13. Muzoliminum

14. Muzoliminum [inn-latin]

15. Muzolimina [inn-spanish]

16. Einecs 259-573-2

17. Brn 0660881

18. Muzolimine [usan:inn:ban]

19. Unii-07z36289zx

20. 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4h-pyrazol-3-one

21. Muzolimine [mi]

22. 3-amino-1-(3,4-dichloro-alpha-methylbenzyl)-2-pyrazolin-5-one

23. Muzolimine [inn]

24. Muzolimine (usan/inn)

25. Muzolimine [usan]

26. 3-amino-1-(3,4-dichloro-alpha-methylbenzyl)-4,5-dihydro-5-pyrazolon

27. 3h-pyrazol-3-one, 2,4-dihydro-5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-

28. 5-amino-2-(1-(3,4-dichlorophenyl)-ethyl)-2,4-dihydro-3h-pyrazol-3-one

29. Muzolimine [mart.]

30. Muzolimine [who-dd]

31. Schembl123392

32. Chembl1697760

33. Dtxsid50866476

34. Chebi:135124

35. 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-3h-pyrazol-3-one

36. Db13801

37. Da-04927

38. Hy-106616

39. Cs-0026158

40. Ft-0759718

41. D05093

42. Q3868794

43. 3-amino-1-(3,4-dichloro-a-methylbenzyl)-2-pyrazolin-5-one

44. 3-amino-1-(3,4-dichloro-.alpha.-methylbenzyl)-2-pyrazolin-5-one

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₁H₁₁Cl₂N₃O
Molecular Weight	272.13 g/mol
XLogP3	2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	271.0279174 g/mol
Monoisotopic Mass	271.0279174 g/mol
Topological Polar Surface Area	58.7 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	348
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Diuretics

Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)

4.2 ATC Code

C - Cardiovascular system

C03 - Diuretics

C03C - High-ceiling diuretics

C03CD - Pyrazolone derivatives

C03CD01 - Muzolimine