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Morphine
Also known as: Morphine sulfate, Schembl29317, Morphinesulfatenarcoticanalgesic
Molecular Formula
C17H21NO7S
Molecular Weight
383.4  g/mol
InChI Key
OOZBZVAQKFGLOL-VYKNHSEDSA-N

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
1 2D Structure

Morphine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;sulfuric acid
2.1.2 InChI
InChI=1S/C17H19NO3.H2O4S/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;1-5(2,3)4/h2-5,10-11,13,16,19-20H,6-8H2,1H3;(H2,1,2,3,4)/t10-,11+,13-,16-,17-;/m0./s1
2.1.3 InChI Key
OOZBZVAQKFGLOL-VYKNHSEDSA-N
2.1.4 Canonical SMILES
CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O.OS(=O)(=O)O
2.1.5 Isomeric SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O.OS(=O)(=O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Chloride, Morphine

2. Contin, Ms

3. Duramorph

4. Morphia

5. Morphine

6. Morphine Chloride

7. Morphine Sulfate

8. Morphine Sulfate (2:1), Anhydrous

9. Morphine Sulfate (2:1), Pentahydrate

10. Ms Contin

11. Oramorph Sr

12. Sdz 202 250

13. Sdz 202-250

14. Sdz 202250

15. Sdz202 250

16. Sdz202-250

17. Sdz202250

18. Sulfate, Morphine

2.2.2 Depositor-Supplied Synonyms

1. Morphine Sulfate

2. Schembl29317

3. Morphinesulfatenarcoticanalgesic

2.3 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 383.4 g/mol
Molecular Formula C17H21NO7S
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count0
Exact Mass383.10387318 g/mol
Monoisotopic Mass383.10387318 g/mol
Topological Polar Surface Area136 Ų
Heavy Atom Count26
Formal Charge0
Complexity576
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameAstramorph pf
PubMed HealthMorphine (Injection)
Active IngredientMorphine sulfate
Dosage FormInjectable
RouteInjection
Strength1mg/ml; 0.5mg/ml
Market StatusPrescription
CompanyFresenius Kabi Usa

2 of 6  
Drug NameDuramorph pf
Active IngredientMorphine sulfate
Dosage FormInjectable
RouteInjection
Strength1mg/ml; 0.5mg/ml
Market StatusPrescription
CompanyHikma Maple

3 of 6  
Drug NameMorphine sulfate
PubMed HealthMorphine Sulfate Liposome (Injection)
Drug ClassesAnalgesic, Anesthetic Adjunct, Central Nervous System Agent
Drug LabelDESCRIPTIONChemically, morphine sulfate is 7, 8-didehydro-4, 5-epoxy-17-methylmorphinan-3, 6-diol sulfate (2:1) (salt) pentahydrate...
Active IngredientMorphine sulfate
Dosage FormTablet, extended release; Tablet; Injectable; Capsule, extended release; Solution
RouteIntramuscular, intravenous; oral; Injection; Oral
Strength2mg/ml; 200mg; 10mg/5ml; 1mg/ml; 8mg/ml (8mg/ml); 30mg; 10mg/ml (10mg/ml); 100mg/5ml; 90mg; 15mg; 120mg; 4mg/ml (4mg/ml); 10mg/ml; 0.5mg/ml; 2mg/ml (2mg/ml); 75mg; 4mg/ml; 5mg/ml; 100mg; 5mg/ml (5mg/ml); 8mg/ml; 50mg; 60mg; 10mg; 15mg/ml; 20mg/5ml; 80mg;
Market StatusPrescription
CompanyClonmel Hlthcare; Vintage Pharms; Mylan Pharms; Upsher Smith; Hospira; Mallinckrodt; Rhodes Pharms; Meridian Medcl; Par Pharm; Roxane; Lannett Holdings; Nesher Pharms; Vistapharm; Actavis Elizabeth; Paddock; Caraco; Ranbaxy Labs; Bd Rx

4 of 6  
Drug NameAstramorph pf
PubMed HealthMorphine (Injection)
Active IngredientMorphine sulfate
Dosage FormInjectable
RouteInjection
Strength1mg/ml; 0.5mg/ml
Market StatusPrescription
CompanyFresenius Kabi Usa

5 of 6  
Drug NameDuramorph pf
Active IngredientMorphine sulfate
Dosage FormInjectable
RouteInjection
Strength1mg/ml; 0.5mg/ml
Market StatusPrescription
CompanyHikma Maple

6 of 6  
Drug NameMorphine sulfate
PubMed HealthMorphine Sulfate Liposome (Injection)
Drug ClassesAnalgesic, Anesthetic Adjunct, Central Nervous System Agent
Drug LabelDESCRIPTIONChemically, morphine sulfate is 7, 8-didehydro-4, 5-epoxy-17-methylmorphinan-3, 6-diol sulfate (2:1) (salt) pentahydrate...
Active IngredientMorphine sulfate
Dosage FormTablet, extended release; Tablet; Injectable; Capsule, extended release; Solution
RouteIntramuscular, intravenous; oral; Injection; Oral
Strength2mg/ml; 200mg; 10mg/5ml; 1mg/ml; 8mg/ml (8mg/ml); 30mg; 10mg/ml (10mg/ml); 100mg/5ml; 90mg; 15mg; 120mg; 4mg/ml (4mg/ml); 10mg/ml; 0.5mg/ml; 2mg/ml (2mg/ml); 75mg; 4mg/ml; 5mg/ml; 100mg; 5mg/ml (5mg/ml); 8mg/ml; 50mg; 60mg; 10mg; 15mg/ml; 20mg/5ml; 80mg;
Market StatusPrescription
CompanyClonmel Hlthcare; Vintage Pharms; Mylan Pharms; Upsher Smith; Hospira; Mallinckrodt; Rhodes Pharms; Meridian Medcl; Par Pharm; Roxane; Lannett Holdings; Nesher Pharms; Vistapharm; Actavis Elizabeth; Paddock; Caraco; Ranbaxy Labs; Bd Rx

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Analgesics, Opioid

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)


Narcotics

Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS. (See all compounds classified as Narcotics.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Opioid Agonist [EPC]; Full Opioid Agonists [MoA]
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  • TABLET, EXTENDED RELEASE;ORAL - 100MG
  • TABLET, EXTENDED RELEASE;ORAL - 15MG
  • TABLET, EXTENDED RELEASE;ORAL - 200MG
  • TABLET, EXTENDED RELEASE;ORAL - 30MG
  • TABLET, EXTENDED RELEASE;ORAL - 60MG
  • INJECTABLE;INJECTION - 1MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
  • INJECTABLE;INJECTION - 5MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
  • SOLUTION;INTRAMUSCULAR - 10MG/0.7ML (10MG/0.7ML)
  • INJECTABLE;INJECTION - 10MG/ML
  • INJECTABLE;INJECTION - 15MG/ML
  • INJECTABLE;INJECTION - 2MG/ML
  • INJECTABLE;INJECTION - 4MG/ML
  • INJECTABLE;INJECTION - 50MG/ML
  • INJECTABLE;INJECTION - 8MG/ML
  • CAPSULE, EXTENDED RELEASE;ORAL - 100MG
  • CAPSULE, EXTENDED RELEASE;ORAL - 10MG
  • CAPSULE, EXTENDED RELEASE;ORAL - 130MG
  • CAPSULE, EXTENDED RELEASE;ORAL - 150MG
  • CAPSULE, EXTENDED RELEASE;ORAL - 200MG
  • CAPSULE, EXTENDED RELEASE;ORAL - 20MG
  • CAPSULE, EXTENDED RELEASE;ORAL - 30MG
  • CAPSULE, EXTENDED RELEASE;ORAL - 40MG
  • CAPSULE, EXTENDED RELEASE;ORAL - 50MG
  • CAPSULE, EXTENDED RELEASE;ORAL - 60MG
  • CAPSULE, EXTENDED RELEASE;ORAL - 70MG
  • CAPSULE, EXTENDED RELEASE;ORAL - 80MG
  • TABLET, EXTENDED RELEASE;ORAL - 100MG
  • TABLET, EXTENDED RELEASE;ORAL - 15MG
  • TABLET, EXTENDED RELEASE;ORAL - 30MG
  • TABLET, EXTENDED RELEASE;ORAL - 60MG
  • TABLET, EXTENDED RELEASE;ORAL - 15MG
  • TABLET, EXTENDED RELEASE;ORAL - 30MG
  • TABLET, EXTENDED RELEASE;ORAL - 60MG
  • SOLUTION;ORAL - 100MG/5ML
  • SOLUTION;ORAL - 10MG/5ML
  • SOLUTION;ORAL - 20MG/5ML
  • TABLET;ORAL - 15MG
  • TABLET;ORAL - 30MG
  • CAPSULE, EXTENDED RELEASE;ORAL - 100MG;4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
  • CAPSULE, EXTENDED RELEASE;ORAL - 20MG;0.8MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
  • CAPSULE, EXTENDED RELEASE;ORAL - 30MG;1.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
  • CAPSULE, EXTENDED RELEASE;ORAL - 50MG;2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
  • CAPSULE, EXTENDED RELEASE;ORAL - 60MG;2.4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
  • CAPSULE, EXTENDED RELEASE;ORAL - 80MG;3.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
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