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Morphine Hydrochloride

Synopsis, Chemistry

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Also known as: 52-26-6, Morphine hcl, Thebametten, Morphine chlorhydrate, Morphine chloride, Epimore

Molecular Formula

C₁₇H₂₀ClNO₃

Molecular Weight

321.8 g/mol

InChI Key

XCKKIKBIPZJUET-VYKNHSEDSA-N

FDA UNII

J28GE0ROVX

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

1 2D Structure

Morphine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;hydrochloride

2.1.2 InChI

InChI=1S/C17H19NO3.ClH/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;/h2-5,10-11,13,16,19-20H,6-8H2,1H3;1H/t10-,11+,13-,16-,17-;/m0./s1

2.1.3 InChI Key

XCKKIKBIPZJUET-VYKNHSEDSA-N

2.1.4 Canonical SMILES

CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O.Cl

2.1.5 Isomeric SMILES

CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O.Cl

2.2 Other Identifiers

2.2.1 UNII

J28GE0ROVX

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Chloride, Morphine

2. Contin, Ms

3. Duramorph

4. Morphia

5. Morphine

6. Morphine Chloride

7. Morphine Sulfate

8. Morphine Sulfate (2:1), Anhydrous

9. Morphine Sulfate (2:1), Pentahydrate

10. Ms Contin

11. Oramorph Sr

12. Sdz 202 250

13. Sdz 202-250

14. Sdz 202250

15. Sdz202 250

16. Sdz202-250

17. Sdz202250

18. Sulfate, Morphine

2.3.2 Depositor-Supplied Synonyms

1. 52-26-6

2. Morphine Hcl

3. Thebametten

4. Morphine Chlorhydrate

5. Morphine Chloride

6. Epimore

7. Ampek

8. (-)-morphine Hydrochloride

9. Theba-intran

10. Vendal

11. Morphinum Muriaticum

12. Morphinium Chloride

13. J28ge0rovx

14. Chebi:55340

15. Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-, Hydrochloride

16. Morphine Hydrochloride Hydrate

17. Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-, Hydrochloride, (5-alpha,6-alpha)-

18. (4r,4ar,7s,7ar,12bs)-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;hydrochloride

19. Unii-j28ge0rovx

20. Morphine-hcl

21. Morphin-hcl

22. Morphine Hydrochloride [usp:jan]

23. Einecs 200-136-2

24. Opso

25. Morphini Hydrochloridum

26. Morphine Hydro Chloride

27. Morphiniumchloride

28. Schembl40902

29. (+/-)-morphine Hydrochloride

30. Morphine Hydrochloric Acid Salt

31. Chembl556578

32. Dtxsid10110023

33. Dtxsid501045894

34. Morphine Hydrochloride [mi]

35. Morphinum Muriaticum [hpus]

36. Akos024458522

37. Morphine Hydrochloride [mart.]

38. Morphine Hydrochloride [who-dd]

39. B5814

40. Morphine Hydrochloride [ep Monograph]

41. Q27124243

42. 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol Hydrochloride

43. 7,8-didehydro-4,5-epoxy-17-methyl-(5?,6?)-morphinan-3,6-diol Hydrochloride

44. Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-, (5alpha,6alpha)-, Hydrochloride

45. Morphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoxy-17-methyl-, Hydrochloride (8ci)

46. (5alpha,6alpha)-7,8-didehydro-4,5-epoxy-17-methyl-morphinan-3,6-diol, Hydrochloride (1:1)

47. Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5.alpha.,6.alpha.)-, Hydrochloride (1:1)

48. Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, Hydrochloride (9ci)

2.4 Create Date

2005-06-01

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₀ClNO₃
Molecular Weight	321.8 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	321.1131712 g/mol
Monoisotopic Mass	321.1131712 g/mol
Topological Polar Surface Area	52.9 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	494
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Analgesics, Opioid

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)

Narcotics

Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS. (See all compounds classified as Narcotics.)