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Monydrin
Also known as: Phenylpropanolamine hydrochloride, (+)-phenylpropanolamine hydrochloride, 40626-29-7, Phenylpropanolamine hydrochloride, (+)-, 184m412sjh, Dl-norephedrine hydrochloride
Molecular Formula
C9H14ClNO
Molecular Weight
187.66  g/mol
InChI Key
DYWNLSQWJMTVGJ-PRCZDLBKSA-N
FDA UNII
184M412SJH

A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.
1 2D Structure

Monydrin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1S,2R)-2-amino-1-phenylpropan-1-ol;hydrochloride
2.1.2 InChI
InChI=1S/C9H13NO.ClH/c1-7(10)9(11)8-5-3-2-4-6-8;/h2-7,9,11H,10H2,1H3;1H/t7-,9-;/m1./s1
2.1.3 InChI Key
DYWNLSQWJMTVGJ-PRCZDLBKSA-N
2.1.4 Canonical SMILES
CC(C(C1=CC=CC=C1)O)N.Cl
2.1.5 Isomeric SMILES
C[C@H]([C@H](C1=CC=CC=C1)O)N.Cl
2.2 Other Identifiers
2.2.1 UNII
184M412SJH
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Dexatrim

2. Hydrochloride, Phenylpropanolamine

3. Norephedrine

4. Phenylpropanolamine

5. Phenylpropanolamine Hydrochloride

6. Prolamine

7. Propagest

8. Triaminic Dm

2.3.2 Depositor-Supplied Synonyms

1. Phenylpropanolamine Hydrochloride

2. (+)-phenylpropanolamine Hydrochloride

3. 40626-29-7

4. Phenylpropanolamine Hydrochloride, (+)-

5. 184m412sjh

6. Dl-norephedrine Hydrochloride

7. (1s,2r)-2-amino-1-phenylpropan-1-ol Hydrochloride

8. 154-41-6

9. Dsstox_cid_5896

10. D-norephedrine Hydrochloride

11. Dsstox_rid_77964

12. Dsstox_gsid_25896

13. (+)-norephedrine Hydrochloride

14. Unii-184m412sjh

15. (1s,2r)-norephedrine Hydrochloride

16. Norephedrine, Hydrochloride, (+)-

17. Einecs 255-008-9

18. (1s,2r)-(+)-norephedrine Hydrochloride

19. Dl-norephedrinhydrochlorid

20. Ncgc00016416-01

21. Cas-154-41-6

22. Schembl16986

23. 1s,2r-phenylpropanolamine Hydrochloride

24. Chembl3189135

25. Dtxsid2025896

26. Tox21_110431

27. Tox21_110431_1

28. Ccg-212747

29. Dl-norephedrine Hydrochloride, >=99%

30. Ncgc00274057-01

31. D-phenylpropanolamine Hydrochloride

32. (1s, 2r)-(+)-norephedrine Hydrochloride

33. (1s,2r)-2-amino-1-phenylpropan-1-ol;hydrochloride

34. D-(+)-norephedrine Hydrochloride, >=98.0% (at)

35. Q27251969

36. Dl-norephedrine Hydrochloride, Sigma Reference Standard

37. Phenylpropanolamine (+)-form Hydrochloride [mi]

38. (s-(r*,s*))-alpha-(1-aminoethyl)benzyl Alcohol Hydrochloride

39. Benzenemethanol, .alpha.-((1r)-1-aminoethyl)-, Hydrochloride (1:1), (.alpha.s)-

40. Phenylpropanolamine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

41. Phenylpropanolamine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

42. (+/-)-phenylpropanolamine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2006-04-28
3 Chemical and Physical Properties
Molecular Weight 187.66 g/mol
Molecular Formula C9H14ClNO
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass187.0763918 g/mol
Monoisotopic Mass187.0763918 g/mol
Topological Polar Surface Area46.2 Ų
Heavy Atom Count12
Formal Charge0
Complexity110
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Nasal Decongestants

Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)


Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)


Adrenergic alpha-Agonists

Drugs that selectively bind to and activate alpha adrenergic receptors. (See all compounds classified as Adrenergic alpha-Agonists.)


Appetite Depressants

Agents that are used to suppress appetite. (See all compounds classified as Appetite Depressants.)


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