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MolPort-001-791-744
Also known as: Propan-2-amine, 2-propanamine, 75-31-0, 2-aminopropane, Monoisopropylamine, 2-propylamine
Molecular Formula
C3H9N
Molecular Weight
59.11  g/mol
InChI Key
JJWLVOIRVHMVIS-UHFFFAOYSA-N
FDA UNII
P8W26T4MTD

1 2D Structure

MolPort-001-791-744

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
propan-2-amine
2.1.2 InChI
InChI=1S/C3H9N/c1-3(2)4/h3H,4H2,1-2H3
2.1.3 InChI Key
JJWLVOIRVHMVIS-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)N
2.2 Other Identifiers
2.2.1 UNII
P8W26T4MTD
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-propylamine

2. 2-propylamine Hydrochloride

3. 2-propylamine Sulfite

2.3.2 Depositor-Supplied Synonyms

1. Propan-2-amine

2. 2-propanamine

3. 75-31-0

4. 2-aminopropane

5. Monoisopropylamine

6. 2-propylamine

7. Sec-propylamine

8. 1-methylethylamine

9. Isopropyl Amine

10. Isopropilamina

11. Propane, 2-amino-

12. 2-aminopropan

13. 2-amino-propaan

14. 2-amino-propano

15. Mfcd00008082

16. Nsc 62775

17. P8w26t4mtd

18. Chebi:15739

19. Nsc-62775

20. 2-propaneamine

21. Isopropilamina [italian]

22. Isopropylamin

23. 2-aminopropan [german]

24. 2-amino-propaan [dutch]

25. 2-amino-propano [italian]

26. Ccris 4318

27. Hsdb 804

28. Einecs 200-860-9

29. Un1221

30. Unii-p8w26t4mtd

31. Isopropylarnine

32. Isoproylamine

33. I-propylamine

34. Iso-propylamine

35. Isopropyl-amine

36. Ai3-15636

37. I-propyl Amine

38. Iso- Propylamine

39. Iso-propyl Amine

40. Propane-2-amine

41. 2-propyl Amine

42. Propan-2 -amine

43. Iso-propylamine Gas

44. Iprnh2

45. (1-methylethyl)amine

46. Isopropylamine Solution (70% Or Less)

47. I-prnh2

48. Isopropylamine, 97%

49. Isopropylamine, 99%

50. Iso-c3h7nh2

51. 2-amino-propane

52. Ec 200-860-9

53. Isopropylamine [mi]

54. Isopropylamine [fhfi]

55. Isopropylamine [hsdb]

56. Isopropylamine [inci]

57. Isopropylamine, >=99.5%

58. Chembl117080

59. Wln: Zy1&1

60. Monoisopropylamine Reagent Grade

61. Dtxsid2025682

62. Fema No. 4238

63. Isopropylamine, >=97.0% (gc)

64. Nsc62775

65. Str00028

66. Zinc8220693

67. Stl194288

68. Akos000119321

69. Un 1221

70. Ft-0611265

71. I0165

72. Isopropylamine, Anhydrous, Analytical Standard

73. Isopropylamine, Saj Special Grade, >=99.0%

74. C06748

75. Isopropylamine [un1221] [flammable Liquid]

76. A838376

77. Q420554

78. Isopropylamine (purified By Distillation From Glass)

79. F2190-0359

80. G4o

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 59.11 g/mol
Molecular Formula C3H9N
XLogP30.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass59.073499291 g/mol
Monoisotopic Mass59.073499291 g/mol
Topological Polar Surface Area26 Ų
Heavy Atom Count4
Formal Charge0
Complexity10.8
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Absorption, Distribution and Excretion

Following a single intravenous injection of (14)C-isopropylamine HCl of 0.3 mg/kg bw into male Wistar rats, radioactivity was rapidly eliminated from the body via the urine with a half-life of about 2 to 4 hr. Following a single intraperitoneal injection of a similar dose, 97% of the radioactivity was excreted in the urine, all being identified as isopropylamine, 1.2% in the feces, and 1% in exhaled air. In in vitro experiments in which isopropylamine was incubated with rat liver microsomes in the presence of a NADPH-generating system, more than 94% was recovered as unchanged compound. /Isopropylamine HCl/

Health Council of the Netherlands, Committee on Updating of Occupational Exposure Limits; Health-Based Reassessment of Administrative Occupational Exposure Limits: Isopropylamine p.4-5 (June 8, 2004). Available from, as of January 12, 2018: https://www.gezondheidsraad.nl/sites/default/files/0015122_0.pdf


In mongrel dogs intravenously infused with isopropylamine (0.25 mg/kg/min, 45 min), an initial rapid and a subsequent slow decline in plasma levels with half life times of 5 and 146 min, respectively, were observed. These values indicate redistribution of isopropylamine into a tissue compartment followed by a slow release into and elimination from the blood. Examinations of tissues 2 hours post-infusion showed highest tissue/plasma ratios (ranging from approximately 5-17) for the kidneys (medulla, cortex), the spleen, the liver, the adrenal glands, and the lungs while significant amounts were found in sections of the brains (ratios of about 3-3.5) and the heart (ratios: ca. 2-3.5) (Pri82).

Health Council of the Netherlands, Committee on Updating of Occupational Exposure Limits; Health-Based Reassessment of Administrative Occupational Exposure Limits: Isopropylamine p.4 (June 8, 2004). Available from, as of January 12, 2018: https://www.gezondheidsraad.nl/sites/default/files/0015122_0.pdf


... Studies on the disposition of isopropylamine indicated that there was significant accumulation of isopropylamine in all tissues as compared to plasma. ...

PMID:7086693 Privitera PJ et al; J Pharmacol Exp Ther 222 (1): 116-21 (1982)


4.2 Biological Half-Life

Following a single intravenous injection of (14)C-isopropylamine HCl of 0.3 mg/kg bw into male Wistar rats, radioactivity was rapidly eliminated from the body via the urine with a half-life of about 2 to 4 hr. /Isopropylamine HCl/

Health Council of the Netherlands, Committee on Updating of Occupational Exposure Limits; Health-Based Reassessment of Administrative Occupational Exposure Limits: Isopropylamine p.4 (June 8, 2004). Available from, as of January 12, 2018: https://www.gezondheidsraad.nl/sites/default/files/0015122_0.pdf


In mongrel dogs intravenously infused with isopropylamine (0.25 mg/kg/min, 45 min), an initial rapid and a subsequent slow decline in plasma levels with half life times of 5 and 146 min, respectively, were observed.

Health Council of the Netherlands, Committee on Updating of Occupational Exposure Limits; Health-Based Reassessment of Administrative Occupational Exposure Limits: Isopropylamine p.4 (June 8, 2004). Available from, as of January 12, 2018: https://www.gezondheidsraad.nl/sites/default/files/0015122_0.pdf


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