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1. Cyclohexanols
1. 108-93-0
2. Cyclohexyl Alcohol
3. Hexahydrophenol
4. 1-cyclohexanol
5. Hydrophenol
6. Hydroxycyclohexane
7. Hexalin
8. Hydralin
9. Adronal
10. Naxol
11. Adronol
12. Anol
13. Cykloheksanol
14. Cicloesanolo
15. Phenol, Hexahydro-
16. Cicloesanolo [italian]
17. Cykloheksanol [polish]
18. Cyclohexanone Cyclohexanol Mixture
19. Cyclohexan-1-ol
20. Nsc 403656
21. Mfcd00003855
22. Chebi:18099
23. 8e7s519m3p
24. Nsc-403656
25. Cxl
26. Cyclohexanols
27. Dsstox_cid_1894
28. Dsstox_rid_76390
29. Dsstox_gsid_21894
30. Hydroxycyclohexane; Nsc 403656; Nsc 54711; Naxol; Phenol, Hexahydro-
31. Cas-108-93-0
32. Hsdb 61
33. Ccris 5896
34. Einecs 203-630-6
35. Brn 0906744
36. Cylcohexanol
37. Unii-8e7s519m3p
38. Ai3-00040
39. Cyclohexyl-alcohol
40. Cyclohexane, Hydroxy-
41. Bdbm5
42. Cyanomethylthioacetic Acid
43. Cyclohexanol [mi]
44. Bmse000431
45. Wln: L6tj Aq
46. Cyclohexanol [hsdb]
47. Ec 203-630-6
48. Schembl5545
49. 4-06-00-00020 (beilstein Handbook Reference)
50. Mls001055343
51. Bidd:er0291
52. Chembl32010
53. Cyclohexanol, P.a., 99.0%
54. Dtxsid4021894
55. Cyclohexanol, Analytical Standard
56. Hms3039k08
57. Zinc1532765
58. Tox21_201481
59. Tox21_302803
60. Bbl013186
61. Cyclohexanol, Reagentplus(r), 99%
62. Nsc403656
63. Stl163965
64. Akos000119038
65. Zinc100502981
66. Db03703
67. Rp10050
68. Ncgc00090982-01
69. Ncgc00090982-02
70. Ncgc00256434-01
71. Ncgc00259032-01
72. Smr000677941
73. Cyclohexanol, Puriss., >=99.0% (gc)
74. Cyclohexanol, Saj First Grade, >=95.0%
75. Db-040851
76. Cs-0017198
77. Cyclohexanol, Jis Special Grade, >=98.0%
78. Ft-0624192
79. Ft-0641073
80. Cyclohexanol, Vetec(tm) Reagent Grade, 98%
81. C00854
82. Q423282
83. Q-200903
84. F0001-0184
| Molecular Weight | 100.16 g/mol |
|---|---|
| Molecular Formula | C6H12O |
| XLogP3 | 1.2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 100.088815002 g/mol |
| Monoisotopic Mass | 100.088815002 g/mol |
| Topological Polar Surface Area | 20.2 Ų |
| Heavy Atom Count | 7 |
| Formal Charge | 0 |
| Complexity | 46.1 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
The substance can be absorbed into the body by inhalation and by ingestion.
International Program on Chemical Safety/Commission of the European Communities; International Chemical Safety Card on Cyclohexanol (November 1998). Available from, as of May 20, 2010: https://www.inchem.org/pages/icsc.html
Animal expt ... In large doses ... /cyclohexanol/ is readily absorbed from the skin ... .
Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 386
Following oral admin ... to rabbits, cmpd is excreted in urine in conjugation with sulfuric & glucuronic acids. Similar results were obtained when animals were subjected to repeated inhalation of cmpd.
Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4648
... Rabbits exposed to lowest concn ... 145 ppm cyclohexanol in air, showed no incr in conjugation of urinary sulfates but excreted 5 times normal amt glucuronic acid.
Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4648
... Incr in glucuronic acid in urine was paralleled by a decr in percentage of inorg sulfates. ... That the urinary sulfate ratio became normal when exposure ceased ... led ... to ... /conclusion/ that there was no prolonged retention in organism.
Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 386
Cyclohexane was hydroxylated to cyclohexanol by rat liver microsomes in presence of NADPH & oxygen. Pretreatment with phenobarbital at 80 mg/kg/day ip stimulated activity 6-fold, while benzopyrene pretreatment at 20 mg/kg ip lowered cyclohexane hydroxylation.
PMID:4388853 ULLRICH V; HOPPE-SEYLER'S Z PHYSIOL CHEM 350 (3): 357 (1969)
Cyclohexanol was identified as the urinary metabolite after admin of cyclohexylamine hydrochloride to rats, rabbits, & guinea pigs (50-500 mg/kg, orally or ip) and humans (25 or 200 mg, orally).
PMID:4655821 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174231 RENWICK AG, RT WILLIAMS; BIOCHEM J 129 (4): 857 (1972)
Fed to rabbits, /cyclohexanol/ ... Is mostly excreted as the glucuronide conjugate (60% of the dose), but a small amt is oxidized further into trans-cyclohexane-1,2-diol (6%).
Parke, D. V. The Biochemistry of Foreign Compounds. Oxford: Pergamon Press, 1968., p. 222
Hepatic NAD-dependent alcohol dehydrogenase ... is responsible for metabolism of ... cyclohexanol ...
Testa, B. and P. Jenner. Drug Metabolism: Chemical & Biochemical Aspects. New York: Marcel Dekker, Inc., 1976., p. 310
For more Metabolism/Metabolites (Complete) data for Cyclohexanol (8 total), please visit the HSDB record page.
No reports found; [TDR, p. 430]
TDR - Ryan RP, Terry CE, Leffingwell SS (eds). Toxicology Desk Reference: The Toxic Exposure and Medical Monitoring Index, 5th Ed. Washington DC: Taylor & Francis, 1999., p. 430
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