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Mivacurium Chloride

Mivacurium Chloride

Synopsis, Chemistry

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DRUG PRODUCT COMPOSITION

SOLUTION;INTRAVENOUS - EQ 10MG BASE/5ML (EQ 2MG BASE/ML), SOLUTION;INTRAVENOUS - EQ 20MG BASE/10ML (EQ 2MG BASE/ML), SOLUTION;INTRAVENOUS - EQ 2MG BASE/ML (EQ 2MG BASE/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

SOLUTION;INTRAVENOUS - EQ 10MG BASE/5ML (EQ 2MG BASE/ML)
SOLUTION;INTRAVENOUS - EQ 20MG BASE/10ML (EQ 2MG BASE/ML)
SOLUTION;INTRAVENOUS - EQ 2MG BASE/ML (EQ 2MG BASE/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

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Also known as: Mivacron, 106861-44-3, Mivacurium chloride (mixture of isomers), Bw-b 1090u, Mivacurium (dichloride), Bis[3-[(1r)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1h-isoquinolin-2-ium-2-yl]propyl] (e)-oct-4-enedioate;dichloride

Molecular Formula

C₅₈H₈₀Cl₂N₂O₁₄

Molecular Weight

1100.2 g/mol

InChI Key

WMSYWJSZGVOIJW-ONUALHDOSA-L

An isoquinoline derivative that is used as a short-acting non-depolarizing agent.

1 2D Structure

Mivacurium Chloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

bis[3-[(1R)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] (E)-oct-4-enedioate;dichloride

2.1.2 InChI

InChI=1S/C58H80N2O14.2ClH/c1-59(25-21-41-35-47(63-3)49(65-5)37-43(41)45(59)29-39-31-51(67-7)57(71-11)52(32-39)68-8)23-17-27-73-55(61)19-15-13-14-16-20-56(62)74-28-18-24-60(2)26-22-42-36-48(64-4)50(66-6)38-44(42)46(60)30-40-33-53(69-9)58(72-12)54(34-40)70-10;;/h13-14,31-38,45-46H,15-30H2,1-12H3;2*1H/q+2;;/p-2/b14-13+;;/t45-,46-,59?,60?;;/m1../s1

2.1.3 InChI Key

WMSYWJSZGVOIJW-ONUALHDOSA-L

2.1.4 Canonical SMILES

C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C(=C3)OC)OC)OC)OC)OC)CCCOC(=O)CCC=CCCC(=O)OCCC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C(=C6)OC)OC)OC)OC)OC)C.[Cl-].[Cl-]

2.1.5 Isomeric SMILES

C[N+]1(CCC2=CC(=C(C=C2[C@H]1CC3=CC(=C(C(=C3)OC)OC)OC)OC)OC)CCCOC(=O)CC/C=C/CCC(=O)OCCC[N+]4(CCC5=CC(=C(C=C5[C@H]4CC6=CC(=C(C(=C6)OC)OC)OC)OC)OC)C.[Cl-].[Cl-]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Bw B 1090u

2. Bw B1090u

3. Bw-b 1090u

4. Bw-b-1090u

5. Bw-b1090u

6. Bwb 1090u

7. Bwb1090u

8. Mivacron

9. Mivacurium

2.2.2 Depositor-Supplied Synonyms

1. Mivacron

2. 106861-44-3

3. Mivacurium Chloride (mixture Of Isomers)

4. Bw-b 1090u

5. Mivacurium (dichloride)

6. Bis[3-[(1r)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1h-isoquinolin-2-ium-2-yl]propyl] (e)-oct-4-enedioate;dichloride

7. Bwb109ou

8. Bw B109ou Dichloride

9. Mivacurii Chloridum

10. Mivacurii Chloridum [latin]

11. Cloruro De Mivacurio

12. Cloruro De Mivacurio [spanish]

13. Chlorure De Mivacurium

14. Chlorure De Mivacurium [french]

15. Ncgc00167469-01

16. Mivacurium Chloride [usan:inn:ban]

17. Unii-600zg213c3

18. Bw-b1090u

19. Mivacron (tn)

20. Mivacron In Dextrose 5% In Plastic Container

21. Bw B1090u Dichloride

22. Chembl984

23. Dsstox_cid_26649

24. Dsstox_rid_81794

25. Dsstox_gsid_46649

26. Schembl41232

27. (r)-1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium Chloride, (e)-4-octenedioate (2:1)

28. Bw-b109ou Dichloride

29. Bw-1090u Dichloride

30. Chebi:6959

31. Dtxsid5046649

32. Schembl10666657

33. Hy-b1700a

34. Mivacurium Chloride (usan/inn)

35. Hms3886m16

36. Tox21_112473

37. Akos025311198

38. 600zg213c3

39. Isoquinolinium, 2,2'-((1,8-dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl))bis(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-((3,4,5-trimethoxyphenyl)methyl)-, Dichloride, (r-(r*,r*-(e)))-

40. Cas-106861-44-3

41. Cs-0013697

42. D00763

43. Q27263131

2.3 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₅₈H₈₀Cl₂N₂O₁₄
Molecular Weight	1100.2 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	30
Exact Mass	1098.4986606 g/mol
Monoisotopic Mass	1098.4986606 g/mol
Topological Polar Surface Area	145 Å²
Heavy Atom Count	76
Formal Charge	0
Complexity	1550
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Neuromuscular Nondepolarizing Agents

Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants. (See all compounds classified as Neuromuscular Nondepolarizing Agents.)

4.2 ATC Code

M - Musculo-skeletal system

M03 - Muscle relaxants

M03A - Muscle relaxants, peripherally acting agents

M03AC - Other quaternary ammonium compounds

M03AC10 - Mivacurium chloride