Find Milnacipran Hydrochloride manufacturers, exporters & distributors on PharmaCompass

Milnacipran Hydrochloride

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

23 API Suppliers, 15 USDMF, 5 JDMF, 7 EU WC, 1 KDMF, 6 NDC API, 8 Listed Suppliers

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Imports

DOSSIERs // Finished Dosage Formulations

31 Dossiers, 31 FDA Orange Book

DRUG PRODUCT COMPOSITION

TABLET;ORAL - 100MG, TABLET;ORAL - 12.5MG, TABLET;ORAL - 25MG, TABLET;ORAL - 50MG

TABLET;ORAL - 100MG
TABLET;ORAL - 12.5MG
TABLET;ORAL - 25MG
TABLET;ORAL - 50MG

RELATED EXCIPIENT COMPANIES

Suppliers, 18 BASF, 14 Kerry, 10 Corel Pharma Chem, 7 Microlex e.U, 6 Seppic, 6 Lonza Capsugel, 6 Ideal Cures Pvt Ltd, 6 Gangwal Chemicals, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 3 Actylis, 3 Kima Chemical, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 2 Sigachi Industries, 2 Nomisma Healthcare, 2 Roquette, 2 Prachin Chemical, 2 Seqens, 2 The Dow Chemical Company, 1 Gangwal Healthcare, 1 ACG Worldwide, 1 Pharmatrans-Sanaq, 1 DKSH, 1 Boai NKY Pharmaceuticals Ltd, 1 Clariant, 1 Aeon Procare, 1 Finar, 1 Nanjing Well Pharmaceutical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Ulanqab Kema New Material, 1 Vasa Pharmachem, 1 Qualicaps

EXCIPIENTS BY APPLICATIONS

47 Coating Systems & Additives, 28 Controlled & Modified Release, 18 Fillers, Diluents & Binders, 12 Lubricants & Glidants, 12 Solubilizers, 9 Topical, 9 Thickeners and Stabilizers, 9 Film Formers & Plasticizers, 8 Granulation, 7 Direct Compression, 6 Parenteral, 6 Disintegrants & Superdisintegrants, 5 Empty Capsules, 5 API Stability Enhancers, 4 Vegetarian Capsules, 3 Emulsifying Agents, 2 Rheology Modifiers, 2 Taste Masking, 2 Coloring Agents, 1 Chewable & Orodispersible Aids, 1 Co-Processed Excipients, 1 Surfactant & Foaming Agents

GLOBAL SALES INFORMATION

4 Finished Drug Prices

4 Finished Drug Prices

PATENTS

4 US Patents

4 US Patents

ANALYTICAL SOLUTION(s)

1 USP Standards, 1 Other Ref. Standards

DIGITAL CONTENT

6 News

6 News

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

960

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

110

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: Milnacipran hcl, Dalcipran, 101152-94-7, Savella, Toledomin, (1r-cis)-milnacipran hydrochloride

Molecular Formula

C₁₅H₂₃ClN₂O

Molecular Weight

282.81 g/mol

InChI Key

XNCDYJFPRPDERF-PBCQUBLHSA-N

FDA UNII

RNZ43O5WW5

A cyclopropanecarboxamide serotonin and norepinephrine reuptake inhibitor (SNRI) that is used in the treatment of FIBROMYALGIA.

1 2D Structure

Milnacipran Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide;hydrochloride

2.1.2 InChI

InChI=1S/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H/t13-,15+;/m1./s1

2.1.3 InChI Key

XNCDYJFPRPDERF-PBCQUBLHSA-N

2.1.4 Canonical SMILES

CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2.Cl

2.1.5 Isomeric SMILES

CCN(CC)C(=O)[C@@]1(C[C@@H]1CN)C2=CC=CC=C2.Cl

2.2 Other Identifiers

2.2.1 UNII

RNZ43O5WW5

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1 Phenyl 1 Diethylaminocarbonyl 2 Aminomethylcyclopropane Hcl

2. 1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane Hcl

3. F 2207

4. F-2207

5. F2207

6. Ixel

7. Midalcipran

8. Milnacipran

9. Savella

2.3.2 Depositor-Supplied Synonyms

1. Milnacipran Hcl

2. Dalcipran

3. 101152-94-7

4. Savella

5. Toledomin

6. (1r-cis)-milnacipran Hydrochloride

7. Ixel

8. 175131-61-0

9. Milnacipran (hydrochloride)

10. F 2207

11. Milnacipran Hydrochloride [usan]

12. Rnz43o5ww5

13. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, Monohydrochloride, (1r,2s)-rel-

14. Cis-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide Hydrochloride

15. Z-2 Aminomethyl-1-phenyl-n,n-diethylcyclopropane-carboxamide Hydrochloride

16. (1rs,2sr)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide Hydrochloride

17. Smr000449266

18. Midalcipran Hydrochloride

19. Rac-milnacipran Hydrochloride

20. Unii-rnz43o5ww5

21. F2207

22. Toledomin (tn)

23. Savella (tn)

24. Ncgc00168780-01

25. 1-phenyl-1-(diethylaminocarbonyl)-2-(aminomethyl)cyclopropane Hydrochloride

26. Cis-(+-)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide Monohydrochloride

27. Dsstox_cid_26785

28. Dsstox_rid_81903

29. Dsstox_gsid_46785

30. Mls000758229

31. Mls001424149

32. Schembl161558

33. Chembl1237129

34. Dtxsid4046785

35. Chebi:31854

36. Hy-b0168a

37. Amy22199

38. Bcp05817

39. Tox21_112641

40. S3140

41. Milnacipran Hydrochloride (jan/usan)

42. Milnacipran Hydrochloride [mi]

43. Akos015950801

44. Ccg-101034

45. Cs-2010

46. Ks-1274

47. Milnacipran Hydrochloride [jan]

48. Nc00284

49. Nsc 759806

50. (1r,2s)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide Hydrochloride

51. (1r,2s)-rel-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide Monohydrochloride

52. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, Monohydrochloride, Cis-(+-)-

53. Milnacipran Hydrochloride [mart.]

54. Milnacipran Hydrochloride [vandf]

55. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, Hydrochloride (1:1), (1r,2s)-rel-

56. Milnacipran Hydrochloride [usp-rs]

57. Milnacipran Hydrochloride [who-dd]

58. Cas-101152-94-7

59. Sw197664-2

60. D01107

61. Milnacipran Hydrochloride [orange Book]

62. Milnacipran Hydrochloride, >=98% (hplc), Solid

63. J-011063

64. Q27288221

65. Milnacipran Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₂₃ClN₂O
Molecular Weight	282.81 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	282.1498911 g/mol
Monoisotopic Mass	282.1498911 g/mol
Topological Polar Surface Area	46.3 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	295
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Savella
PubMed Health	Milnacipran (By mouth)
Drug Classes	Central Nervous System Agent
Drug Label	Milnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor; it inhibits norepinephrine uptake with greater potency than serotonin. It is a racemic mixture with the chemical name: ()-[1R(S),2S(R)]-2-(aminomethyl)-N,N-di...
Active Ingredient	Milnacipran hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	25mg; 100mg; 50mg; 12.5mg
Market Status	Prescription
Company	Cypress Bioscience

2 of 2
Drug Name	Savella
PubMed Health	Milnacipran (By mouth)
Drug Classes	Central Nervous System Agent
Drug Label	Milnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor; it inhibits norepinephrine uptake with greater potency than serotonin. It is a racemic mixture with the chemical name: ()-[1R(S),2S(R)]-2-(aminomethyl)-N,N-di...
Active Ingredient	Milnacipran hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	25mg; 100mg; 50mg; 12.5mg
Market Status	Prescription
Company	Cypress Bioscience

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Analgesics, Non-Narcotic

A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)

Serotonin and Noradrenaline Reuptake Inhibitors

Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS. (See all compounds classified as Serotonin and Noradrenaline Reuptake Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Serotonin Uptake Inhibitors [MoA]; Serotonin and Norepinephrine Reuptake Inhibitor [EPC]; Norepinephrine Uptake Inhibitors [MoA]