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1. 84604-20-6
2. Milkthistleextract
3. 65666-07-1
4. A835184
5. (2s)-3,5,7-trihydroxy-2-[(2s,3r)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one
6. (2s)-3,5,7-trihydroxy-2-[(2s,3r)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2h-1-benzopyran-4-one
| Molecular Weight | 482.4 g/mol |
|---|---|
| Molecular Formula | C25H22O10 |
| XLogP3 | 2.4 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 4 |
| Exact Mass | 482.12129689 g/mol |
| Monoisotopic Mass | 482.12129689 g/mol |
| Topological Polar Surface Area | 155 Ų |
| Heavy Atom Count | 35 |
| Formal Charge | 0 |
| Complexity | 750 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 3 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
EXPL THER The 2008 Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) study, sponsored by the National Institutes of Health (NIH), found that hepatitis C patients who used silymarin had fewer and milder symptoms of liver disease and somewhat better quality of life but no change in virus activity or liver inflammation.
NIH National Center forComplementary and Alternative Medicine; Milk Thistle; Available from, as of November 4, 2013: https://nccam.nih.gov/health/milkthistle/ataglance.htm
EXPL THER A 2012 clinical trial, cofunded by NCCAM and the National Institute of Diabetes and Digestive and Kidney Diseases, showed that two higher-than-usual doses of silymarin were no better than placebo for chronic hepatitis C in people who had not responded to standard antiviral treatment.
NIH National Center forComplementary and Alternative Medicine; Milk Thistle; Available from, as of November 4, 2013: https://nccam.nih.gov/health/milkthistle/ataglance.htm
EXPL THER ...laboratory studies suggested that milk thistle may benefit the liver by protecting and promoting the growth of liver cells, fighting oxidation (a chemical process that can damage cells), and inhibiting inflammation. However, results from small clinical trials of milk thistle for liver diseases have been mixed, and two rigorously designed studies found no benefit.
NIH National Center forComplementary and Alternative Medicine; Milk Thistle; Available from, as of November 4, 2013: https://nccam.nih.gov/health/milkthistle/ataglance.htm
EXPL THER Silymarin has been used in pregnant women who have a bile blockage in the liver, with no toxic effects to the patient or fetus. Silymarin have also been given to children intravenously for mushroom poisoning.
National Cancer Institute; Milk Thistle PDQ; Available from, as of November 2013: https://www.cancer.gov/cancertopics/pdq/cam/milkthistle/Patient/Page2#Section_10
For more Therapeutic Uses (Complete) data for Milk Thistle Extract (16 total), please visit the HSDB record page.
Milk thistle may lower blood sugar levels. People with diabetes or hypoglycemia, or people taking drugs or supplements that affect blood sugar levels, should use caution.
NIH National Center forComplementary and Alternative Medicine; Milk Thistle; Available from, as of November 4, 2013: https://nccam.nih.gov/health/milkthistle/ataglance.htm
Milk thistle can produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy).
NIH National Center forComplementary and Alternative Medicine; Milk Thistle; Available from, as of November 4, 2013: https://nccam.nih.gov/health/milkthistle/ataglance.htm
In clinical trials, milk thistle appears to be well tolerated in recommended doses. Occasionally, people report various gastrointestinal side effects.
NIH National Center forComplementary and Alternative Medicine; Milk Thistle; Available from, as of November 4, 2013: https://nccam.nih.gov/health/milkthistle/ataglance.htm
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