Find Mezigdomide manufacturers, exporters & distributors on PharmaCompass

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0INTERMEDIATES

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Chemistry

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Also known as: Cc-92480, 2259648-80-9, Unii-la88ih4o02, Mezigdomide [usan], La88ih4o02, Cc92480
Molecular Formula
C32H30FN5O4
Molecular Weight
567.6  g/mol
InChI Key
YTINZZFBHWSAGL-NDEPHWFRSA-N
FDA UNII
LA88IH4O02

Mezigdomide
Mezigdomide is a modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and antineoplastic activities. Upon administration, mezigdomide specifically binds to cereblon (CRBN), thereby affecting the ubiquitin E3 ligase activity, and targeting certain substrate proteins for ubiquitination. This induces proteasome-mediated degradation of certain transcription factors, some of which are transcriptional repressors in T-cells. This leads to modulation of the immune system, including activation of T-lymphocytes, and downregulation of the activity of other proteins, some of which play key roles in the proliferation of certain cancer cell types. CRBN, the substrate recognition component of the CRL4-CRBN E3 ubiquitin ligase complex, plays a key role in the ubiquitination of certain proteins.
1 2D Structure

Mezigdomide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[4-[[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile
2.1.2 InChI
InChI=1S/C32H30FN5O4/c33-26-16-23(17-34)8-9-27(26)37-14-12-36(13-15-37)18-21-4-6-22(7-5-21)20-42-29-3-1-2-24-25(29)19-38(32(24)41)28-10-11-30(39)35-31(28)40/h1-9,16,28H,10-15,18-20H2,(H,35,39,40)/t28-/m0/s1
2.1.3 InChI Key
YTINZZFBHWSAGL-NDEPHWFRSA-N
2.1.4 Canonical SMILES
C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCN(CC5)C6=C(C=C(C=C6)C#N)F
2.1.5 Isomeric SMILES
C1CC(=O)NC(=O)[C@H]1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCN(CC5)C6=C(C=C(C=C6)C#N)F
2.2 Other Identifiers
2.2.1 UNII
LA88IH4O02
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Cc-92480

2. 2259648-80-9

3. Unii-la88ih4o02

4. Mezigdomide [usan]

5. La88ih4o02

6. Cc92480

7. Who 11455

8. (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile

9. 4-[4-[[4-[[2-[(3s)-2,6-dioxopiperidin-3-yl]-1-oxo-3h-isoindol-4-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile

10. (83s)-12-fluoro-71,82,86-trioxo-71,73-dihydro-6-oxa-7(4,2)-isoindola-2(1,4)-piperazina-8(3)-piperidina-1(1),4(1,4)-dibenzenaoctaphane-14-carbonitrile

11. Benzonitrile, 4-(4-((4-(((2-((3s)-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1hisoindol-4-yl)oxy)methyl)phenyl)methyl)-1-piperazinyl)-3-fluoro-

12. Qfc

13. Mezigdomide [who-dd]

14. Mezigdomide [inn]

15. Chembl4648616

16. Schembl20608563

17. Gtpl12718

18. Bcp32805

19. Ex-a5597

20. S8975

21. Akos040732735

22. At18067

23. Compound 4 [pmid: 32130004]

24. Ms-30267

25. Hy-129395

26. Cc 92480; Cc92480

27. Cs-0105182

28. 4-(4-((4-(((2-((3s)-2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1h-isoindol-4- Yl)oxy)methyl)phenyl)methyl)piperazin-1-yl)-3-fluorobenzonitrile

29. 4-[4-({4-[({2-[(3s)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1h-isoindol-4-yl}oxy)methyl]phenyl}methyl)piperazin-1-yl]-3-fluorobenzonitrile

30. Benzonitrile, 4-(4-((4-(((2-((3s)-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1h-isoindol-4-yl)oxy)methyl)phenyl)methyl)-1-piperazinyl)-3-fluoro-

2.4 Create Date
2019-03-16
3 Chemical and Physical Properties
Molecular Weight 567.6 g/mol
Molecular Formula C32H30FN5O4
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area106
Heavy Atom Count42
Formal Charge0
Complexity1050
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of mature B-cell neoplasms


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ABOUT THIS PAGE

Looking for 2259648-80-9 / Mezigdomide API manufacturers, exporters & distributors?

Mezigdomide manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Mezigdomide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Mezigdomide manufacturer or Mezigdomide supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Mezigdomide manufacturer or Mezigdomide supplier.

PharmaCompass also assists you with knowing the Mezigdomide API Price utilized in the formulation of products. Mezigdomide API Price is not always fixed or binding as the Mezigdomide Price is obtained through a variety of data sources. The Mezigdomide Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Mezigdomide

Synonyms

Cc-92480, 2259648-80-9, Unii-la88ih4o02, Mezigdomide [usan], La88ih4o02, Cc92480

Cas Number

2259648-80-9

Unique Ingredient Identifier (UNII)

LA88IH4O02

About Mezigdomide

Mezigdomide is a modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and antineoplastic activities. Upon administration, mezigdomide specifically binds to cereblon (CRBN), thereby affecting the ubiquitin E3 ligase activity, and targeting certain substrate proteins for ubiquitination. This induces proteasome-mediated degradation of certain transcription factors, some of which are transcriptional repressors in T-cells. This leads to modulation of the immune system, including activation of T-lymphocytes, and downregulation of the activity of other proteins, some of which play key roles in the proliferation of certain cancer cell types. CRBN, the substrate recognition component of the CRL4-CRBN E3 ubiquitin ligase complex, plays a key role in the ubiquitination of certain proteins.

Mezigdomide Manufacturers

A Mezigdomide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Mezigdomide, including repackagers and relabelers. The FDA regulates Mezigdomide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Mezigdomide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Mezigdomide Suppliers

A Mezigdomide supplier is an individual or a company that provides Mezigdomide active pharmaceutical ingredient (API) or Mezigdomide finished formulations upon request. The Mezigdomide suppliers may include Mezigdomide API manufacturers, exporters, distributors and traders.

Mezigdomide GMP

Mezigdomide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Mezigdomide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Mezigdomide GMP manufacturer or Mezigdomide GMP API supplier for your needs.

Mezigdomide CoA

A Mezigdomide CoA (Certificate of Analysis) is a formal document that attests to Mezigdomide's compliance with Mezigdomide specifications and serves as a tool for batch-level quality control.

Mezigdomide CoA mostly includes findings from lab analyses of a specific batch. For each Mezigdomide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Mezigdomide may be tested according to a variety of international standards, such as European Pharmacopoeia (Mezigdomide EP), Mezigdomide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Mezigdomide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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