Metoclopramide Hydrochloride

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

21 API Suppliers, 10 USDMF, 3 CEP/COS, 3 EU WC, 9 NDC API, 14 Listed Suppliers

DEVELOPMENTS

2 Drug(s) in Development

2 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports, FDF Imports

INTERMEDIATES

2 Suppliers

2 Suppliers

DOSSIERs // Finished Dosage Formulations

108 Dossiers, 77 FDA Orange Book, 5 Europe, 7 Canada, 4 South Africa, 15 Listed Dossiers

DRUG PRODUCT COMPOSITION

INJECTABLE;INJECTION - EQ 5MG BASE/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, ORALLY DISINTEGRATING;ORAL - EQ 10MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, ORALLY DISINTEGRATING;ORAL - EQ 5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

INJECTABLE;INJECTION - EQ 5MG BASE/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, ORALLY DISINTEGRATING;ORAL - EQ 10MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, ORALLY DISINTEGRATING;ORAL - EQ 5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

Suppliers, 28 Roquette, 27 Kerry, 17 SPI Pharma, 17 BASF, 16 Microlex e.U, 12 Gangwal Healthcare, 10 Sigachi Industries, 7 Gangwal Chemicals, 7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 6 Actylis, 6 DFE Pharma, 5 Rochem International Inc, 5 Boai NKY Pharmaceuticals Ltd, 4 ACG Worldwide, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 4 Pharmatrans-Sanaq, 4 Ingredion Pharma Solutions, 3 Nanjing Well Pharmaceutical, 3 Vasa Pharmachem, 3 Lonza Capsugel, 3 DKSH, 3 Prachin Chemical, 2 Ulanqab Kema New Material, 2 Shijiazhuang Huaxu Pharmaceutical, 2 Corel Pharma Chem, 1 Pfanstiehl, 1 Alcedo Pharmachem, 1 Ideal Cures Pvt Ltd, 1 Qualicaps, 1 Seppic, 1 Evonik, 1 Zhejiang Huakang Pharmaceutical, 1 Finar

EXCIPIENTS BY APPLICATIONS

82 Fillers, Diluents & Binders, 42 Direct Compression, 32 Disintegrants & Superdisintegrants, 23 Granulation, 23 Taste Masking, 18 Chewable & Orodispersible Aids, 18 Thickeners and Stabilizers, 15 Lubricants & Glidants, 15 Co-Processed Excipients, 15 Film Formers & Plasticizers, 14 Parenteral, 10 Controlled & Modified Release, 10 Coating Systems & Additives, 10 Solubilizers, 8 Empty Capsules, 4 Topical, 2 Emulsifying Agents, 2 API Stability Enhancers, 1 Rheology Modifiers, 1 Soft Gelatin

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 5 Finished Drug Prices

MARKET PLACE

10 APIs, 1 DOSSIERS // FDF

PATENTS

4 US Patents

4 US Patents

ANALYTICAL SOLUTION(s)

1 EDQM Standards, 1 USP Standards, 1 Other Ref. Standards

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2 News

2 News

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US DMFs Filed

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API REF. PRICE (USD / KG)

112

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

10.00

Annual Reports

FDF Market Place

EXCIPIENTS

208

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: 7232-21-5, Maxolon, Metoclopramide hcl, Metoclopramide monohydrochloride, Cerucal, Paspertin

Molecular Formula

C₁₄H₂₃Cl₂N₃O₂

Molecular Weight

336.3 g/mol

InChI Key

RVFUNJWWXKCWNS-UHFFFAOYSA-N

FDA UNII

7B1QZY5SWZ

A dopamine D2 antagonist that is used as an antiemetic.

1 2D Structure

Metoclopramide Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;hydrochloride

2.1.2 InChI

InChI=1S/C14H22ClN3O2.ClH/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H

2.1.3 InChI Key

RVFUNJWWXKCWNS-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl.Cl

2.2 Other Identifiers

2.2.1 UNII

7B1QZY5SWZ

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxybenzamide

2. Cerucal

3. Dihydrochloride, Metoclopramide

4. Hydrochloride, Metoclopramide

5. Maxolon

6. Metaclopramide

7. Metoclopramide

8. Metoclopramide Dihydrochloride

9. Metoclopramide Monohydrochloride

10. Metoclopramide Monohydrochloride, Monohydrate

11. Monohydrochloride, Metoclopramide

12. Primperan

13. Reglan

14. Rimetin

2.3.2 Depositor-Supplied Synonyms

1. 7232-21-5

2. Maxolon

3. Metoclopramide Hcl

4. Metoclopramide Monohydrochloride

5. Cerucal

6. Paspertin

7. Clopra

8. Reglan

9. 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxybenzamide Hydrochloride

10. Metozolv

11. Metozolv Odt

12. Metoclopramide Hydrochloride Anhydrous

13. 7b1qzy5swz

14. Metoclopramide (hydrochloride)

15. Mls000069667

16. 4-amino-5-chloro-n-[2-(diethylamino)ethyl]-2-methoxybenzamide;hydrochloride

17. Benzamide, 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxy-, Monohydrochloride

18. Nsc-354467

19. Rimetin

20. Smr000058471

21. 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-o-anisamide Hydrochloride

22. Primperan (tablet)

23. Metoclopramide Hydrochloride 100 Microg/ml In Acetonitrile

24. Metoclopramide Intensol

25. Reglan Odt

26. Ccris 7142

27. Sr-01000000165

28. Einecs 230-634-5

29. Unii-7b1qzy5swz

30. Nsc 354467

31. 4-amino-5-chloro-n-[2-(diethylamino)ethyl]-o-anisamide Hydrochloride

32. Prestwick_332

33. 4-amino-5-chloro-n-(2-diethylaminoethyl)-2-methoxy-benzamide

34. Mfcd00058011

35. Metoclopramidehcl

36. Opera_id_1671

37. Mls001074186

38. Mls002222202

39. O-anisamide, Monohydrochloride

40. Schembl205200

41. Spectrum1500410

42. Chembl1256771

43. Dtxsid10964306

44. Hms1568j19

45. Hms1920n15

46. Metoclopramide Hydrochloride, Solid

47. Pharmakon1600-01500410

48. Bcp28471

49. Tox21_500762

50. Nsc354467

51. Nsc757117

52. 4-amino-5-chloro-n-(2-diethylaminoethyl)-2-methoxybenzamide Hydrochloride

53. Akos015889947

54. O-anisamide, 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-, Monohydrochloride

55. Ccg-212697

56. Hs-0006

57. Lp00762

58. Nc00519

59. 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxybenzamide Monohydrochloride

60. Ncgc00094102-01

61. Ncgc00094102-02

62. Ncgc00094102-03

63. Ncgc00094102-04

64. Ncgc00094102-05

65. Ncgc00261447-01

66. Wln: 2n2&2mvr Dz Cg Fo1 &gh

67. Eu-0100762

68. Ft-0657870

69. Ft-0672375

70. S4289

71. Sw196611-3

72. Vu0239518-5

73. A14247

74. M 0763

75. A923754

76. Sr-01000000165-2

77. Sr-01000000165-7

78. Q27267998

79. 4-amino-5-chloro-n-(2-diethylaminoethyl)-2-methoxybenzamide Hcl

80. 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-o-anisamidmonohydrochloride

81. 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-o-anisamide Monohydrochloride

82. Benzamide, 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxy-, Monohydrochloride (9ci)

83. Benzamide, 4-amino-5-chloro-n-[2-(diethylamino)ethyl]-2-methoxy-, Hydrochloride (1:1)

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₂₃Cl₂N₃O₂
Molecular Weight	336.3 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Exact Mass	335.1167324 g/mol
Monoisotopic Mass	335.1167324 g/mol
Topological Polar Surface Area	67.6 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	300
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Metoclopramide hydrochloride
Drug Label	Metoclopramide hydrochloride is a white or practically white, crystalline, odorless or practically odorless powder. It is very soluble in water, freely soluble in alcohol, sparingly soluble in chloroform, practically insoluble in ether. Chemically it...
Active Ingredient	Metoclopramide hydrochloride
Dosage Form	Tablet; Injectable; Tablet, orally disintegrating; Solution
Route	Injection; Oral
Strength	eq 5mg base; eq 5mg base/5ml; eq 5mg base/ml; eq 10mg base
Market Status	Prescription
Company	Vintage Pharms; Wockhardt; Silarx; Ani Pharms; Hospira; Teva; Pharm Assoc; Teva Pharms Usa; Northstar Hlthcare; Par Pharm; Novel Labs; Watson Labs; Vistapharm; Ipca Labs; Mutual Pharm; Bd Rx

2 of 4
Drug Name	Metozolv odt
PubMed Health	Metoclopramide
Drug Classes	Antiemetic, Diagnostic Agent, Stimulant, Gastrointestinal
Drug Label	METOZOLV ODT is an orally disintegrating tablet formulation of metoclopramide hydrochloride. The 5 mg strength is a round white tablet debossed on one side with a 5 and plain on the other side; it is comprised of 5 mg metoclopramide (as 5.91...
Active Ingredient	Metoclopramide hydrochloride
Dosage Form	Tablet, orally disintegrating
Route	Oral
Strength	eq 5mg base
Market Status	Prescription
Company	Salix Pharms

3 of 4
Drug Name	Metoclopramide hydrochloride
Drug Label	Metoclopramide hydrochloride is a white or practically white, crystalline, odorless or practically odorless powder. It is very soluble in water, freely soluble in alcohol, sparingly soluble in chloroform, practically insoluble in ether. Chemically it...
Active Ingredient	Metoclopramide hydrochloride
Dosage Form	Tablet; Injectable; Tablet, orally disintegrating; Solution
Route	Injection; Oral
Strength	eq 5mg base; eq 5mg base/5ml; eq 5mg base/ml; eq 10mg base
Market Status	Prescription
Company	Vintage Pharms; Wockhardt; Silarx; Ani Pharms; Hospira; Teva; Pharm Assoc; Teva Pharms Usa; Northstar Hlthcare; Par Pharm; Novel Labs; Watson Labs; Vistapharm; Ipca Labs; Mutual Pharm; Bd Rx

4 of 4
Drug Name	Metozolv odt
PubMed Health	Metoclopramide
Drug Classes	Antiemetic, Diagnostic Agent, Stimulant, Gastrointestinal
Drug Label	METOZOLV ODT is an orally disintegrating tablet formulation of metoclopramide hydrochloride. The 5 mg strength is a round white tablet debossed on one side with a 5 and plain on the other side; it is comprised of 5 mg metoclopramide (as 5.91...
Active Ingredient	Metoclopramide hydrochloride
Dosage Form	Tablet, orally disintegrating
Route	Oral
Strength	eq 5mg base
Market Status	Prescription
Company	Salix Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Dopamine D2 Receptor Antagonists

Compounds and drugs that bind to and inhibit or block the activation of DOPAMINE D2 RECEPTORS. (See all compounds classified as Dopamine D2 Receptor Antagonists.)

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Dopamine-2 Receptor Antagonist [EPC]; Dopamine D2 Antagonists [MoA]

Find Metoclopramide Hydrochloride manufacturers, exporters & distributors on PharmaCompass

Metoclopramide Hydrochloride

Metoclopramide Hydrochloride

Synopsis

Chemistry

APIs // Active Pharmaceutical Ingredients

21 API Suppliers

10 USDMF

3 CEP/COS

3 EU WC

9 NDC API

14 Listed Suppliers

DEVELOPMENTS

2 Drug(s) in Development

PRICE INFORMATION

API Reference Price

API Exports

API Imports

FDF Exports

FDF Imports

INTERMEDIATES

2 Suppliers

DOSSIERs // Finished Dosage Formulations

108 Dossiers

77 FDA Orange Book

5 Europe

7 Canada

4 South Africa

15 Listed Dossiers

DRUG PRODUCT COMPOSITION

INJECTABLE;INJECTION - EQ 5MG BASE/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET, ORALLY DISINTEGRATING;ORAL - EQ 10MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET, ORALLY DISINTEGRATING;ORAL - EQ 5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

Suppliers

28 Roquette

27 Kerry

17 SPI Pharma

17 BASF

16 Microlex e.U

12 Gangwal Healthcare

10 Sigachi Industries

7 Gangwal Chemicals

7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

6 Actylis

6 DFE Pharma

5 Rochem International Inc

5 Boai NKY Pharmaceuticals Ltd

4 ACG Worldwide

4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

4 Pharmatrans-Sanaq

4 Ingredion Pharma Solutions

3 Nanjing Well Pharmaceutical

3 Vasa Pharmachem

3 Lonza Capsugel

3 DKSH

3 Prachin Chemical

2 Ulanqab Kema New Material

2 Shijiazhuang Huaxu Pharmaceutical

2 Corel Pharma Chem

1 Pfanstiehl

1 Alcedo Pharmachem

1 Ideal Cures Pvt Ltd

1 Qualicaps

1 Seppic

1 Evonik

1 Zhejiang Huakang Pharmaceutical

1 Finar

EXCIPIENTS BY APPLICATIONS

82 Fillers, Diluents & Binders

42 Direct Compression

32 Disintegrants & Superdisintegrants

23 Granulation

23 Taste Masking

18 Chewable & Orodispersible Aids

18 Thickeners and Stabilizers

15 Lubricants & Glidants

15 Co-Processed Excipients

15 Film Formers & Plasticizers

14 Parenteral

INJECTABLE;INJECTION - EQ 5MG BASE/ML Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET, ORALLY DISINTEGRATING;ORAL - EQ 10MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET, ORALLY DISINTEGRATING;ORAL - EQ 5MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons