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Chemistry

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Also known as: 33402-03-8, Metaraminol tartrate, Metaraminol (+)-bitartrate salt, Metaraminol (tartrate), (-)-metaraminol bitartrate, Metaradrine tartrate
Molecular Formula
C13H19NO8
Molecular Weight
317.29  g/mol
InChI Key
VENXSELNXQXCNT-IJYXXVHRSA-N
FDA UNII
ZC4202M9P3

Metaraminol Bitartrate
A sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. It has been used primarily as a vasoconstrictor in the treatment of HYPOTENSION.
1 2D Structure

Metaraminol Bitartrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[(1R,2S)-2-amino-1-hydroxypropyl]phenol;(2R,3R)-2,3-dihydroxybutanedioic acid
2.1.2 InChI
InChI=1S/C9H13NO2.C4H6O6/c1-6(10)9(12)7-3-2-4-8(11)5-7;5-1(3(7)8)2(6)4(9)10/h2-6,9,11-12H,10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t6-,9-;1-,2-/m01/s1
2.1.3 InChI Key
VENXSELNXQXCNT-IJYXXVHRSA-N
2.1.4 Canonical SMILES
CC(C(C1=CC(=CC=C1)O)O)N.C(C(C(=O)O)O)(C(=O)O)O
2.1.5 Isomeric SMILES
C[C@@H]([C@@H](C1=CC(=CC=C1)O)O)N.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
2.2 Other Identifiers
2.2.1 UNII
ZC4202M9P3
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Aramine

2. Araminol

3. Bitartrate, Metaraminol

4. Hydroxyphenylpropanolamine

5. Isophenylephrine

6. M Hydroxynorephedrine

7. M Hydroxyphenylpropanolamine

8. M-hydroxynorephedrine

9. M-hydroxyphenylpropanolamine

10. Meta Hydroxynorephedrine

11. Meta-hydroxynorephedrine

12. Metaradrin

13. Metaraminol

14. Metaraminol Bitartrate (1:1)

15. Metaraminol Tartrate

16. Tartrate, Metaraminol

2.3.2 Depositor-Supplied Synonyms

1. 33402-03-8

2. Metaraminol Tartrate

3. Metaraminol (+)-bitartrate Salt

4. Metaraminol (tartrate)

5. (-)-metaraminol Bitartrate

6. Metaradrine Tartrate

7. Zc4202m9p3

8. Nsc-758425

9. Araminum

10. Benzenemethanol, A-[(1s)-1-aminoethyl]-3-hydroxy-, (ar)-,(2r,3r)-2,3-dihydroxybutanedioate (1:1) (salt)

11. Levicor

12. Metaramin

13. Levicor Ampullen

14. Araminum Ampullen

15. 3-[(1r,2s)-2-amino-1-hydroxypropyl]phenol;(2r,3r)-2,3-dihydroxybutanedioic Acid

16. L-metraminol Bitartrate

17. Metaradrine Bitartrate

18. Aramine (sympathominetic)

19. Metaraminol Tartrate (1:1)

20. Unii-zc4202m9p3

21. Ims Metaraminol Bitartrat Ampullen

22. Metaraminol (r,r)-hydrogentartrat

23. Metaraminol Bitartrate [usp:jan]

24. Aramine (tn)

25. Einecs 251-502-3

26. Metaraminol Bitatrate

27. Prestwick3_000197

28. Metaraminol Bitartrate Salt

29. (-)-m-hydroxyphenylpropanolamine Bitartrate Salt

30. Schembl40982

31. Bspbio_000153

32. Bspbio_003506

33. Bpbio1_000169

34. 1-alpha-(1-aminoethyl)-m-hydroxybenzyl Alcohol Bitartrate

35. (-)-alpha-(1-aminoethyl)-m-hydroxybenzyl Alcohol Bitartrate

36. Hms2093a03

37. Hms3885j21

38. L-1-(m-hydroxyphenyl)-2-amino-1-propanol-d-hydrogen Tartrate

39. Metaraminol Bitartrate (jan/usp)

40. Pharmakon1600-01503251

41. Metaraminol Bitartrate [mi]

42. Ex-a1348

43. Hy-b1116

44. Metaraminol Bitartrate [jan]

45. 1-alpha-(1-aminoethyl)-m-hydroxybenzyl Alcohol Hydrogen D-tartrate

46. Metaraminol Tartrate [mart.]

47. Nsc758425

48. Metaraminol Bitartrate [vandf]

49. Metaraminol Tartrate [who-dd]

50. (-)-alpha-(1-aminoethyl)-m-hydroxybenzyl Alcohol Tartrate (1:1) (salt)

51. Akos037515726

52. Ccg-213141

53. Cs-4715

54. Metaraminol Bitartrate [usp-rs]

55. Nsc 758425

56. Benzyl Alcohol, Alpha-(1-aminoethyl)-m-hydroxy-, (-)-, Tartrate (1:1) (salt)

57. Ac-33541

58. Benzenemethanol, Alpha-(1-aminoethyl)-3-hydroxy-, (r-(r*,s*))-, (r-(r*,r*))-2,3-dihydroxybutanedioate (1:1) (salt)

59. Bm166414

60. Metaraminol Bitartrate [orange Book]

61. Metaraminol Bitartrate (hydrogen L-tartrate)

62. Metaraminol Bitartrate [usp Impurity]

63. Metaraminol Bitartrate [usp Monograph]

64. D01019

65. F18205

66. Metaraminol Bitartrate, (r-(r*,s*))-

67. 402m038

68. Sr-05000001611

69. J-019180

70. Sr-05000001611-1

71. Q27107333

72. Metaraminol Bitartrate, United States Pharmacopeia (usp) Reference Standard

73. (-)-.alpha.-(1-aminoethyl)-m-hydroxybenzyl Alcohol Tartrate (1:1) (salt)

74. 3-((1r,2s)-2-amino-1-hydroxypropyl)phenol (2r,3r)-2,3-dihydroxysuccinate

75. Benzyl Alcohol, Alpha-(1-aminoethyl)-m-hydroxy-, Tartrate (1:1), D-(-)-

76. Benzenemethanol, Alpha-((1s)-1-aminoethyl)-3-hydroxy-, (alphar)-, (2r,3r)-2,3-dihydroxybutanedioate (1:1)

2.3.3 Other Synonyms

1. (-)-metaraminol

2. Hydroxynorephedrine

3. L-metaraminol

4. Metaradrine

5. M-hydroxypropadrine

6. Pressonex

7. Metaraminol

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 317.29 g/mol
Molecular Formula C13H19NO8
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass317.11106656 g/mol
Monoisotopic Mass317.11106656 g/mol
Topological Polar Surface Area182 Ų
Heavy Atom Count22
Formal Charge0
Complexity274
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameMetaraminol bitartrate
Active IngredientMetaraminol bitartrate
Dosage FormInjectable
RouteInjection
Strengtheq 10mg base/ml
Market StatusPrescription
CompanyFresenius Kabi Usa

2 of 2  
Drug NameMetaraminol bitartrate
Active IngredientMetaraminol bitartrate
Dosage FormInjectable
RouteInjection
Strengtheq 10mg base/ml
Market StatusPrescription
CompanyFresenius Kabi Usa

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)


Vasoconstrictor Agents

Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)


Adrenergic alpha-1 Receptor Agonists

Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Agonists.)


EU WC

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Metaraminol Bitartrate BP

Date of Issue : 2022-08-04

Valid Till : 2025-03-04

Written Confirmation Number : WC-0427A3-4

Address of the Firm : Plot No.49 & 50, J.N. Pharma City, Parawada (M), Visakhapatnam - 531019, Andhra ...

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NDC API

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Virtual BoothMalladi is a leader in Ephedrine, Pseudoephedrine Salts & Phenylephrine HCl // USFDA, EDQM, ANSM, KFDA, and TGA inspected.

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METARAMINOL BITARTRATE

NDC Package Code : 57218-750

Start Marketing Date : 2017-01-15

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

Malladi

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METARAMINOL BITARTRATE

NDC Package Code : 64274-9001

Start Marketing Date : 2021-02-08

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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Listed Suppliers

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  • fda
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Virtual BoothMalladi is a leader in Ephedrine, Pseudoephedrine Salts & Phenylephrine HCl // USFDA, EDQM, ANSM, KFDA, and TGA inspected.

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Metaraminol Bitartrate

About the Company : Malladi Drugs & Pharmaceuticals Ltd was founded in 1980 by microbiologist Mr. M L N Sastry. Within a few years, Malladi established itself as a leader in manufacturing ephedrine an...

Malladi Drugs & Pharmaceuticals Ltd was founded in 1980 by microbiologist Mr. M L N Sastry. Within a few years, Malladi established itself as a leader in manufacturing ephedrine and pseudoephedrine salts. Today, it is the leading manufacturer of APIs in the cough and cold segment. It also has a dominant presence in several therapeutic segments like antihistamines, anti-convulsants, anti-depressants and anxiolytics (CNS). Malladi exports its products to around 60 countries and over 85% of its revenue is generated from exports. Its manufacturing facilities have been approved by the FDA, EDQM, KFDA, TGA and various other regulatory agencies.
Malladi

02

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Virtual BoothLifecare Labs has been developing innovative products in specialist areas of medicine.

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Metaraminol Bitartrate

About the Company : Lifecare Labs specializes in producing bulk drugs (APIs) and intermediates that adhere to the industry's stringent quality parameters. Its objective is to deliver excellence throug...

Lifecare Labs specializes in producing bulk drugs (APIs) and intermediates that adhere to the industry's stringent quality parameters. Its objective is to deliver excellence through its 'quality designed for excellence' mission and meet its customers' requirements. Cost-effectiveness is a top priority for the company, and it aims to establish long-term relationships with its clients. Lifecare Labs possesses state-of-the-art facilities for manufacturing bulk drugs (APIs) and intermediates and has dedicated units for products. Its mission is to become a globally recognized company responsible for its customers, business partners and society.
LifeCare Laboratories

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Metaraminol Bitartrate

About the Company : Established in 2016, a state-of-the-art R&D facility engaged in the development of Novel processes for Bulk Actives including Deuterated Actives, Advanced Intermediates and up the ...

Established in 2016, a state-of-the-art R&D facility engaged in the development of Novel processes for Bulk Actives including Deuterated Actives, Advanced Intermediates and up the value chain. With experience, Anvitha Life Care Private Limited has knowledge and expertise as a leader in chemical research. Every decision is inspired by our main mission, which is to provide the highest standard of product and services to our clients. In this rapidly changing industry, we’ve realized the importance of continually updating our approach to stay relevant in the market, and are committed to just that.
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Dipharma

Italy
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Dipharma

Italy
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Metaraminol

About the Company : Dipharma is a leading European manufacturer of Active Pharmaceutical Ingredients that has been developing innovative and proprietary processes since 1949. We support our custome...

Dipharma is a leading European manufacturer of Active Pharmaceutical Ingredients that has been developing innovative and proprietary processes since 1949. We support our customers worldwide with a strong and well resourced R&D team, three cGMP facilities in Europe, and offer world-renowned expertise in handling hazardous chemical processes. Our customers can benefit from our broad portfolio of generic Active Pharmaceutical Ingredients and a wide range of advanced technologies available for custom synthesis. They can rely on the highest quality standards, but it does not stop there, they can count on our experience in innovation.
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METARAMINOL BITARTRATE

About the Company : A globally renowned manufacturer of Small Volume Parenterals (SVPs), Gland Pharma was founded in 1978 at Hyderabad by a visionary, PVN Raju, who has always thought far ahead of his...

A globally renowned manufacturer of Small Volume Parenterals (SVPs), Gland Pharma was founded in 1978 at Hyderabad by a visionary, PVN Raju, who has always thought far ahead of his time. Since inception, Gland Pharma stands testimony to the founder’s exemplary commitment to Quality, having emerged as a global player with presence in about 90 countries in five continents. We have a wide range of injectables, including vials, ampoules, pre-filled syringes, lyophilized vials, dry powders, infusions and ophthalmic solutions.
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Metaraminol Bitartrate

About the Company : Hunan Warrant Pharmaceutical Co., Ltd. is a high-tech joint-stock company founded in 2001. With 3 production bases and 2 R&D center, which is engaged in manufacture & supply of API...

Hunan Warrant Pharmaceutical Co., Ltd. is a high-tech joint-stock company founded in 2001. With 3 production bases and 2 R&D center, which is engaged in manufacture & supply of APIs and Intermediates, Solid Dosage Formulations, Herbal Extracts, most of the APIs and all formulation production lines are new GMP certified. Hunan Warrant Chiral Pharmaceutical Co., Ltd. belongs to Hunan Warrant Parmaceutical Co., located in Ltd. & occupies more than 70 000 square meters, Tongguan Circuliar Economy Industrial Park in Wangcheng. It is a CFDA approved pharmaceutical company, focusing on the APIs & advanced intermediates manufacturing in China.
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Metaraminol Bitartrate

About the Company : Liaoyuan Silver Eagle Pharmaceutical Co., Ltd. was founded in 1978, formerly known as Jilin Chemical Industry Company Liaoyuan Pharmaceutical Factory No. 4. Ltd. was renamed as Lia...

Liaoyuan Silver Eagle Pharmaceutical Co., Ltd. was founded in 1978, formerly known as Jilin Chemical Industry Company Liaoyuan Pharmaceutical Factory No. 4. Ltd. was renamed as Liaoyuan Silver Eagle Pharmaceutical Company in 1999 through restructuring. Covering an area of more than 50,000 square meters, the company is a pharmaceutical company specializing in the production of pharmaceutical raw materials and pharmaceutical intermediates.
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SM BIOMED

Malaysia
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SM BIOMED

Malaysia
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Metaraminol Bitartrate

About the Company : Established in 1991, SM Biomed is a joint venture company pioneering the manufacture of API (active pharmaceutical ingredients) products in Malaysia. Company has grown several fold...

Established in 1991, SM Biomed is a joint venture company pioneering the manufacture of API (active pharmaceutical ingredients) products in Malaysia. Company has grown several folds as a market leader in the manufacture of macrolide antibiotics. Quality in the products & excellent service to our clients has been the essence of our success. Asia’s largest producer and exporter of Synthetic Macrolide antibiotics.Malaysia’s largest exporter of pharmaceuticals. We shall learn, we shall seek, attain higher peaks, soar and grow as a major force for the millennium.
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Metaraminol Bitartrate

About the Company : SMS Pharmaceuticals Ltd. is a global player in API manufacturing having a strong research and manufacturing team supported by state of the art facilities. What started off as a sin...

SMS Pharmaceuticals Ltd. is a global player in API manufacturing having a strong research and manufacturing team supported by state of the art facilities. What started off as a single facility - single product manufacturing company in 1990 grew to be a multi-location group having product list spreading across an array of therapeutic segments. SMS was given the export house status in the year 1997-98. SMS is currently a listed company having ever appreciating international and domestic customer base.
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API Reference Price

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Metaraminol Bitartrate (200 mg)

CAS Number : 33402-03-8

Quantity Per Vial : 200

Sale Unit : mg

Price : $245.00

Details : Material Origin- Chemical Synthesis; USMCA- N...

Monograph :

Storage :

Code/Batch No : Catalog #1396003 / R064J1

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Looking for 33402-03-8 / Metaraminol Bitartrate API manufacturers, exporters & distributors?

Metaraminol Bitartrate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Metaraminol Bitartrate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Metaraminol Bitartrate manufacturer or Metaraminol Bitartrate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Metaraminol Bitartrate manufacturer or Metaraminol Bitartrate supplier.

PharmaCompass also assists you with knowing the Metaraminol Bitartrate API Price utilized in the formulation of products. Metaraminol Bitartrate API Price is not always fixed or binding as the Metaraminol Bitartrate Price is obtained through a variety of data sources. The Metaraminol Bitartrate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Metaraminol Bitartrate

Synonyms

33402-03-8, Metaraminol tartrate, Metaraminol (+)-bitartrate salt, Metaraminol (tartrate), (-)-metaraminol bitartrate, Metaradrine tartrate

Cas Number

33402-03-8

Unique Ingredient Identifier (UNII)

ZC4202M9P3

About Metaraminol Bitartrate

A sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. It has been used primarily as a vasoconstrictor in the treatment of HYPOTENSION.

Metaraminol Bitartrate Manufacturers

A Metaraminol Bitartrate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Metaraminol Bitartrate, including repackagers and relabelers. The FDA regulates Metaraminol Bitartrate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Metaraminol Bitartrate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Metaraminol Bitartrate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Metaraminol Bitartrate Suppliers

A Metaraminol Bitartrate supplier is an individual or a company that provides Metaraminol Bitartrate active pharmaceutical ingredient (API) or Metaraminol Bitartrate finished formulations upon request. The Metaraminol Bitartrate suppliers may include Metaraminol Bitartrate API manufacturers, exporters, distributors and traders.

click here to find a list of Metaraminol Bitartrate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Metaraminol Bitartrate USDMF

A Metaraminol Bitartrate DMF (Drug Master File) is a document detailing the whole manufacturing process of Metaraminol Bitartrate active pharmaceutical ingredient (API) in detail. Different forms of Metaraminol Bitartrate DMFs exist exist since differing nations have different regulations, such as Metaraminol Bitartrate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Metaraminol Bitartrate DMF submitted to regulatory agencies in the US is known as a USDMF. Metaraminol Bitartrate USDMF includes data on Metaraminol Bitartrate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Metaraminol Bitartrate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Metaraminol Bitartrate suppliers with USDMF on PharmaCompass.

Metaraminol Bitartrate WC

A Metaraminol Bitartrate written confirmation (Metaraminol Bitartrate WC) is an official document issued by a regulatory agency to a Metaraminol Bitartrate manufacturer, verifying that the manufacturing facility of a Metaraminol Bitartrate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Metaraminol Bitartrate APIs or Metaraminol Bitartrate finished pharmaceutical products to another nation, regulatory agencies frequently require a Metaraminol Bitartrate WC (written confirmation) as part of the regulatory process.

click here to find a list of Metaraminol Bitartrate suppliers with Written Confirmation (WC) on PharmaCompass.

Metaraminol Bitartrate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Metaraminol Bitartrate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Metaraminol Bitartrate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Metaraminol Bitartrate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Metaraminol Bitartrate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Metaraminol Bitartrate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Metaraminol Bitartrate suppliers with NDC on PharmaCompass.

Metaraminol Bitartrate GMP

Metaraminol Bitartrate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Metaraminol Bitartrate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Metaraminol Bitartrate GMP manufacturer or Metaraminol Bitartrate GMP API supplier for your needs.

Metaraminol Bitartrate CoA

A Metaraminol Bitartrate CoA (Certificate of Analysis) is a formal document that attests to Metaraminol Bitartrate's compliance with Metaraminol Bitartrate specifications and serves as a tool for batch-level quality control.

Metaraminol Bitartrate CoA mostly includes findings from lab analyses of a specific batch. For each Metaraminol Bitartrate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Metaraminol Bitartrate may be tested according to a variety of international standards, such as European Pharmacopoeia (Metaraminol Bitartrate EP), Metaraminol Bitartrate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Metaraminol Bitartrate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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