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Mephentermine Sulfate

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Also known as: Mephentermine sulfate, 6190-60-9 (sulfate), Mephentermine sodium, N,2-dimethyl-1-phenylpropan-2-amine,sulfuric acid,dihydrate;n,2-dimethyl-1-phenylpropan-2-amine,sulfuric acid,dihydrate, 2-propanamine, 2,n-dimethyl-1-phenyl-, sulfate, Mls002153976

Molecular Formula

C₁₁H₁₉NO₄S

Molecular Weight

261.34 g/mol

InChI Key

NZKLHVGUPFNBFD-UHFFFAOYSA-N

A sympathomimetic agent with specificity for alpha-1 adrenergic receptors. It is used to maintain BLOOD PRESSURE in hypotensive states such as following SPINAL ANESTHESIA.

1 2D Structure

Mephentermine Sulfate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N,2-dimethyl-1-phenylpropan-2-amine;sulfuric acid

2.1.2 InChI

InChI=1S/C11H17N.H2O4S/c1-11(2,12-3)9-10-7-5-4-6-8-10;1-5(2,3)4/h4-8,12H,9H2,1-3H3;(H2,1,2,3,4)

2.1.3 InChI Key

NZKLHVGUPFNBFD-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)(CC1=CC=CC=C1)NC.OS(=O)(=O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Mephentermine

2. Mephentermine Sulfate

3. Mephentermine Sulfate (2:1)

4. Sulfate, Mephentermine

2.2.2 Depositor-Supplied Synonyms

1. Mephentermine Sulfate

2. 6190-60-9 (sulfate)

3. Mephentermine Sodium

4. N,2-dimethyl-1-phenylpropan-2-amine,sulfuric Acid,dihydrate;n,2-dimethyl-1-phenylpropan-2-amine,sulfuric Acid,dihydrate

5. 2-propanamine, 2,n-dimethyl-1-phenyl-, Sulfate

6. Mls002153976

7. Spectrum1503250

8. Schembl6237301

9. Chembl1200996

10. Hms500l11

11. Hms1922m15

12. Hms2092p22

13. Hms2236o06

14. Hms3369h09

15. Pharmakon1600-01503250

16. Ccg-39977

17. Nsc758424

18. Ncgc00095030-01

19. Ncgc00095030-02

20. Smr001233313

21. Sr-05000001843

22. Sr-05000001843-1

2.3 Create Date

2006-03-07

3 Chemical and Physical Properties

Molecular Formula	C₁₁H₁₉NO₄S
Molecular Weight	261.34 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	261.10347926 g/mol
Monoisotopic Mass	261.10347926 g/mol
Topological Polar Surface Area	95 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	204
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adrenergic alpha-1 Receptor Agonists

Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Agonists.)

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

Vasoconstrictor Agents

Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)