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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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API REF. PRICE (USD/KG)

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Chemistry

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Also known as: Ch5132799, 1007207-67-1, Ch-5132799, Ch 5132799, Izorlisib, Chembl1684984
Molecular Formula
C15H19N7O3S
Molecular Weight
377.4  g/mol
InChI Key
JEGHXKRHKHPBJD-UHFFFAOYSA-N
FDA UNII
JCL936W835

MEN1611
Izorlisib is an orally bioavailable inhibitor of the class I phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) catalytic subunit alpha (PIK3CA), with potential antineoplastic activity. Upon administration, izorlisib selectively binds to and inhibits PIK3CA and its mutated forms in the PI3K/Akt (protein kinase B)/mammalian target of rapamycin (mTOR) pathway. This results in both apoptosis and growth inhibition in PIK3CA-expressing tumor cells. By specifically targeting PIK3CA, izorlisib may be more efficacious and less toxic than pan-PI3K inhibitors. In addition, izorlisib also targets mutated forms of PI3K gamma (PI3Kg). It may also stimulate the immune system to restore CD8+ T-cell activation and cytotoxicity. Dysregulation of the PI3K/Akt/mTOR pathway is often found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to chemo- and radio-therapy. PIK3CA, one of the most frequently mutated oncogenes, encodes the p110-alpha catalytic subunit of the class I PI3K. In most solid tumors, the activation of the PI3K pathway is induced by mutations of PIK3CA.
1 2D Structure

MEN1611

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-(7-methylsulfonyl-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine
2.1.2 InChI
InChI=1S/C15H19N7O3S/c1-26(23,24)22-3-2-11-12(10-8-17-14(16)18-9-10)19-15(20-13(11)22)21-4-6-25-7-5-21/h8-9H,2-7H2,1H3,(H2,16,17,18)
2.1.3 InChI Key
JEGHXKRHKHPBJD-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CS(=O)(=O)N1CCC2=C(N=C(N=C21)N3CCOCC3)C4=CN=C(N=C4)N
2.2 Other Identifiers
2.2.1 UNII
JCL936W835
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ch 5132799

2. Ch-5132799

3. Ch5132799

2.3.2 Depositor-Supplied Synonyms

1. Ch5132799

2. 1007207-67-1

3. Ch-5132799

4. Ch 5132799

5. Izorlisib

6. Chembl1684984

7. Ch5132799 (pa-799)

8. Jcl936w835

9. Pa799

10. Pa-799

11. 5-(7-methanesulfonyl-2-morpholin-4-yl-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-ylamine

12. (5-(7-methylsulfonyl-2-(morpholin-4-yl)-6,7-dihydro-5h-pyrrolo(2,3-d)pyrimidin-4-yl)pyrimidin-2-yl)amine

13. Unii-jcl936w835

14. 5-(7-methylsulfonyl-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine

15. Izorlisib [inn]

16. Mls006010989

17. Gtpl7743

18. Schembl2377154

19. Dtxsid40678540

20. Ex-a997

21. Men1611

22. Hms3656h15

23. Hms3750i19

24. Bcp02894

25. Men-1611

26. Bdbm50338197

27. Mfcd22419020

28. Nsc762382

29. Nsc800984

30. S2699

31. Zinc66074200

32. Akos025404886

33. Bcp9000513

34. Ccg-264982

35. Cs-0981

36. Db13051

37. Nsc-762382

38. Nsc-800984

39. Sb20410

40. Ncgc00346650-01

41. Ncgc00346650-06

42. 5-[7-(methanesulfonyl)-2-(morpholin-4-yl)-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine

43. Ac-28422

44. As-16285

45. Hy-15466

46. Smr004702790

47. Bcp0726000261

48. Sw220190-1

49. J-000203

50. Q27075949

51. 2-pyrimidinamine, 5-[6,7-dihydro-7-(methylsulfonyl)-2-(4-morpholinyl)-5h-pyrrolo[2,3-d]pyrimidin-4-yl]-

52. 5-[7-(methylsulfonyl)-2-(morpholin-4-yl)-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine

53. 5-[7-methanesulfonyl-2-(morpholin-4-yl)-5h,6h,7h-pyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine

2.4 Create Date
2010-12-06
3 Chemical and Physical Properties
Molecular Weight 377.4 g/mol
Molecular Formula C15H19N7O3S
XLogP3-0.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count3
Exact Mass377.12700867 g/mol
Monoisotopic Mass377.12700867 g/mol
Topological Polar Surface Area136 Ų
Heavy Atom Count26
Formal Charge0
Complexity587
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1007207-67-1 / MEN1611 API manufacturers, exporters & distributors?

MEN1611 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of MEN1611 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right MEN1611 manufacturer or MEN1611 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred MEN1611 manufacturer or MEN1611 supplier.

PharmaCompass also assists you with knowing the MEN1611 API Price utilized in the formulation of products. MEN1611 API Price is not always fixed or binding as the MEN1611 Price is obtained through a variety of data sources. The MEN1611 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

MEN1611

Synonyms

Ch5132799, 1007207-67-1, Ch-5132799, Ch 5132799, Izorlisib, Chembl1684984

Cas Number

1007207-67-1

Unique Ingredient Identifier (UNII)

JCL936W835

About MEN1611

Izorlisib is an orally bioavailable inhibitor of the class I phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) catalytic subunit alpha (PIK3CA), with potential antineoplastic activity. Upon administration, izorlisib selectively binds to and inhibits PIK3CA and its mutated forms in the PI3K/Akt (protein kinase B)/mammalian target of rapamycin (mTOR) pathway. This results in both apoptosis and growth inhibition in PIK3CA-expressing tumor cells. By specifically targeting PIK3CA, izorlisib may be more efficacious and less toxic than pan-PI3K inhibitors. In addition, izorlisib also targets mutated forms of PI3K gamma (PI3Kg). It may also stimulate the immune system to restore CD8+ T-cell activation and cytotoxicity. Dysregulation of the PI3K/Akt/mTOR pathway is often found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to chemo- and radio-therapy. PIK3CA, one of the most frequently mutated oncogenes, encodes the p110-alpha catalytic subunit of the class I PI3K. In most solid tumors, the activation of the PI3K pathway is induced by mutations of PIK3CA.

MEN1611 Manufacturers

A MEN1611 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of MEN1611, including repackagers and relabelers. The FDA regulates MEN1611 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. MEN1611 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

MEN1611 Suppliers

A MEN1611 supplier is an individual or a company that provides MEN1611 active pharmaceutical ingredient (API) or MEN1611 finished formulations upon request. The MEN1611 suppliers may include MEN1611 API manufacturers, exporters, distributors and traders.

MEN1611 GMP

MEN1611 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of MEN1611 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right MEN1611 GMP manufacturer or MEN1611 GMP API supplier for your needs.

MEN1611 CoA

A MEN1611 CoA (Certificate of Analysis) is a formal document that attests to MEN1611's compliance with MEN1611 specifications and serves as a tool for batch-level quality control.

MEN1611 CoA mostly includes findings from lab analyses of a specific batch. For each MEN1611 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

MEN1611 may be tested according to a variety of international standards, such as European Pharmacopoeia (MEN1611 EP), MEN1611 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (MEN1611 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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