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    Chemistry

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    Also known as: Fluphenazine dihydrochloride, 146-56-5, Prolixin, Anatensol, Permitil, Fluphenazine (dihydrochloride)
    Molecular Formula
    C22H28Cl2F3N3OS
    Molecular Weight
    510.4  g/mol
    InChI Key
    MBHNWCYEGXQEIT-UHFFFAOYSA-N
    FDA UNII
    ZOU145W1XL
    Fluphenazine
    A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE.
    1 2D Structure

    Fluphenazine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;dihydrochloride
    2.1.2 InChI
    InChI=1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;;/h1-2,4-7,16,29H,3,8-15H2;2*1H
    2.1.3 InChI Key
    MBHNWCYEGXQEIT-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO.Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    ZOU145W1XL
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Flufenazin

    2. Fluphenazine

    3. Hydrochloride, Fluphenazine

    4. Lyogen

    5. Prolixin

    2.3.2 Depositor-Supplied Synonyms

    1. Fluphenazine Dihydrochloride

    2. 146-56-5

    3. Prolixin

    4. Anatensol

    5. Permitil

    6. Fluphenazine (dihydrochloride)

    7. Tensofin

    8. Moditen

    9. Squibb 4918

    10. Dapotum

    11. Omca

    12. Fluphenazine Hcl

    13. Calmansial

    14. Flufenazin

    15. Lyorodin

    16. Liogen

    17. Fluphenazine Chloride

    18. Fluphenazine Dihcl

    19. Fluorophenazine Dihydrochloride

    20. Zou145w1xl

    21. Valamina

    22. 1-(2-hydroxyethyl)-4-(3-(2-trifluoromethyl-10-phenothiazinylpropyl)piperazine Dihydrochloride

    23. 1-piperazineethanol, 4-(3-(2-(trifluoromethyl)-10h-phenothiazin-10-yl)propyl)-, Dihydrochloride

    24. 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazineethanol Dihydrochloride

    25. Nsc-179197

    26. Trancin

    27. A 4077

    28. 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;dihydrochloride

    29. Permitil Hydrochloride

    30. 10-(3-(4-(2-hydroxyethyl)piperazinyl)propyl)-2-trifluoromethylphenothiazine Dihydrochloride

    31. 1-piperazineethanol, 4-[3-[2-(trifluoromethyl)-10h-phenothiazin-10-yl]propyl]-, Dihydrochloride

    32. 2-(4-(3-(2-(trifluoromethyl)-10h-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol Dihydrochloride

    33. Ccris 4032

    34. Nsc 62323

    35. Sr-01000003048

    36. Einecs 205-674-1

    37. Unii-zou145w1xl

    38. Nsc 179197

    39. Siqualone

    40. Fluphenazine 2hcl

    41. Prolixin (tn)

    42. 2-(4-(3-(2-(trifluoromethyl)-10h-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-ol Dihydrochloride

    43. 2-(4-{3-[2-(trifluoromethyl)-10h-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol Dihydrochloride

    44. Prestwick_225

    45. Fluphenazine Hydrochloride [usp:ban:jan]

    46. Schembl41634

    47. Spectrum1500994

    48. Chebi:5126

    49. Flufenazine Hydrochloride

    50. Chembl1448187

    51. Dtxsid00892922

    52. Hms1568p22

    53. Hms1921o14

    54. Bcp18079

    55. Hy-a0081

    56. Tox21_500555

    57. S4569

    58. Fluphenazine Hydrochloride (jan/usp)

    59. Akos015960787

    60. Ccg-212902

    61. Cs-4290

    62. Lp00555

    63. 1-piperazineethanol, 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-, Dihydrochloride

    64. Fluphenazine Hydrochloride [jan]

    65. Fluphenazine Dihydrochloride [mi]

    66. Ncgc00093941-01

    67. Ncgc00093941-02

    68. Ncgc00093941-03

    69. Ncgc00261240-01

    70. Ac-12201

    71. Bs-15804

    72. Fluphenazine Hydrochloride [mart.]

    73. Fluphenazine Hydrochloride [vandf]

    74. S4569 Fluphenazine (dihydrochloride).cd

    75. Fluphenazine Hydrochloride [usp-rs]

    76. Fluphenazine Hydrochloride [who-dd]

    77. Fluphenazine Hydrochloride [who-ip]

    78. Eu-0100555

    79. F1240

    80. Ft-0668755

    81. C72785

    82. D00791

    83. F 4765

    84. Fluphenazine Hydrochloride [orange Book]

    85. Fluphenazine Hydrochloride [usp Impurity]

    86. Fluphenazine Hydrochloride [usp Monograph]

    87. Fluphenazini Hydrochloridum [who-ip Latin]

    88. Sr-01000003048-2

    89. Sr-01000003048-9

    90. W-108125

    91. Fluphenazine Dihydrochloride 100 Microg/ml In Methanol

    92. Q27295826

    93. Z2784093501

    94. Fluphenazine Dihydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    95. Fluphenazine Dihydrochloride, European Pharmacopoeia (ep) Reference Standard

    96. Fluphenazine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    97. Fluphenazine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    98. 2-(4-(3-(2-(trifluoromethyl)-10h-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanoldihydrochloride

    99. 2-(4-{3-[2-(trifluoromethyl)-10h-phenothiazin-10-yl]propyl}-1-piperazinyl)ethanol Dihydrochloride

    100. 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol,dihydrochloride

    101. Fluphenazine Dihydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 510.4 g/mol
    Molecular Formula C22H28Cl2F3N3OS
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count6
    Exact Mass509.1282236 g/mol
    Monoisotopic Mass509.1282236 g/mol
    Topological Polar Surface Area55.2 Ų
    Heavy Atom Count32
    Formal Charge0
    Complexity544
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameFluphenazine hydrochloride
    PubMed HealthFluphenazine Hydrochloride (By mouth)
    Drug ClassesAnalgesic, Antipsychotic
    Drug LabelFluphenazine hydrochloride is a trifluoromethyl phenothiazine derivative intended for the management of schizophrenia. Chemically it is 4-[3-[2-(Trifluoromethyl) phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride which may be represented...
    Active IngredientFluphenazine hydrochloride
    Dosage FormElixir; Tablet; Concentrate; Injectable
    RouteInjection; Oral
    Strength2.5mg; 1mg; 2.5mg/ml; 2.5mg/5ml; 5mg; 5mg/ml; 10mg
    Market StatusPrescription
    CompanyPharm Assoc; Sandoz; Fresenius Kabi Usa; Lannett; Mylan

    2 of 2  
    Drug NameFluphenazine hydrochloride
    PubMed HealthFluphenazine Hydrochloride (By mouth)
    Drug ClassesAnalgesic, Antipsychotic
    Drug LabelFluphenazine hydrochloride is a trifluoromethyl phenothiazine derivative intended for the management of schizophrenia. Chemically it is 4-[3-[2-(Trifluoromethyl) phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride which may be represented...
    Active IngredientFluphenazine hydrochloride
    Dosage FormElixir; Tablet; Concentrate; Injectable
    RouteInjection; Oral
    Strength2.5mg; 1mg; 2.5mg/ml; 2.5mg/5ml; 5mg; 5mg/ml; 10mg
    Market StatusPrescription
    CompanyPharm Assoc; Sandoz; Fresenius Kabi Usa; Lannett; Mylan

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Phenothiazines [CS]; Phenothiazine [EPC]

    API Reference Price

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    05-Jan-2021
    11-Apr-2025
    KGS
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    ABOUT THIS PAGE

    Looking for 146-56-5 / Fluphenazine API manufacturers, exporters & distributors?

    Fluphenazine manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Fluphenazine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Fluphenazine manufacturer or Fluphenazine supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Fluphenazine manufacturer or Fluphenazine supplier.

    PharmaCompass also assists you with knowing the Fluphenazine API Price utilized in the formulation of products. Fluphenazine API Price is not always fixed or binding as the Fluphenazine Price is obtained through a variety of data sources. The Fluphenazine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Fluphenazine

    Synonyms

    Fluphenazine dihydrochloride, 146-56-5, Prolixin, Anatensol, Permitil, Fluphenazine (dihydrochloride)

    Cas Number

    146-56-5

    Unique Ingredient Identifier (UNII)

    ZOU145W1XL

    About Fluphenazine

    A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE.

    Lyogen Manufacturers

    A Lyogen manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Lyogen, including repackagers and relabelers. The FDA regulates Lyogen manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Lyogen API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Lyogen manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Lyogen Suppliers

    A Lyogen supplier is an individual or a company that provides Lyogen active pharmaceutical ingredient (API) or Lyogen finished formulations upon request. The Lyogen suppliers may include Lyogen API manufacturers, exporters, distributors and traders.

    click here to find a list of Lyogen suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Lyogen USDMF

    A Lyogen DMF (Drug Master File) is a document detailing the whole manufacturing process of Lyogen active pharmaceutical ingredient (API) in detail. Different forms of Lyogen DMFs exist exist since differing nations have different regulations, such as Lyogen USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Lyogen DMF submitted to regulatory agencies in the US is known as a USDMF. Lyogen USDMF includes data on Lyogen's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Lyogen USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Lyogen suppliers with USDMF on PharmaCompass.

    Lyogen CEP

    A Lyogen CEP of the European Pharmacopoeia monograph is often referred to as a Lyogen Certificate of Suitability (COS). The purpose of a Lyogen CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Lyogen EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Lyogen to their clients by showing that a Lyogen CEP has been issued for it. The manufacturer submits a Lyogen CEP (COS) as part of the market authorization procedure, and it takes on the role of a Lyogen CEP holder for the record. Additionally, the data presented in the Lyogen CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Lyogen DMF.

    A Lyogen CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Lyogen CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Lyogen suppliers with CEP (COS) on PharmaCompass.

    Lyogen WC

    A Lyogen written confirmation (Lyogen WC) is an official document issued by a regulatory agency to a Lyogen manufacturer, verifying that the manufacturing facility of a Lyogen active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Lyogen APIs or Lyogen finished pharmaceutical products to another nation, regulatory agencies frequently require a Lyogen WC (written confirmation) as part of the regulatory process.

    click here to find a list of Lyogen suppliers with Written Confirmation (WC) on PharmaCompass.

    Lyogen NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Lyogen as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Lyogen API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Lyogen as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Lyogen and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Lyogen NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Lyogen suppliers with NDC on PharmaCompass.

    Lyogen GMP

    Lyogen Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Lyogen GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Lyogen GMP manufacturer or Lyogen GMP API supplier for your needs.

    Lyogen CoA

    A Lyogen CoA (Certificate of Analysis) is a formal document that attests to Lyogen's compliance with Lyogen specifications and serves as a tool for batch-level quality control.

    Lyogen CoA mostly includes findings from lab analyses of a specific batch. For each Lyogen CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Lyogen may be tested according to a variety of international standards, such as European Pharmacopoeia (Lyogen EP), Lyogen JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Lyogen USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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