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Also known as: 1058137-23-7, E-3810, E-3810 amine, E-3810 free base, Al-3810, Pp449xa4bh

Molecular Formula

C₂₆H₂₅N₃O₄

Molecular Weight

443.5 g/mol

InChI Key

CUDVHEFYRIWYQD-UHFFFAOYSA-N

FDA UNII

PP449XA4BH

Lucitanib is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. Lucitanib inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types.

1 2D Structure

Lucitanib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-N-methylnaphthalene-1-carboxamide

2.1.2 InChI

InChI=1S/C26H25N3O4/c1-28-25(30)19-5-3-4-16-12-17(6-7-18(16)19)33-22-8-11-29-21-14-24(23(31-2)13-20(21)22)32-15-26(27)9-10-26/h3-8,11-14H,9-10,15,27H2,1-2H3,(H,28,30)

2.1.3 InChI Key

CUDVHEFYRIWYQD-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CNC(=O)C1=CC=CC2=C1C=CC(=C2)OC3=C4C=C(C(=CC4=NC=C3)OCC5(CC5)N)OC

2.2 Other Identifiers

2.2.1 UNII

PP449XA4BH

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Al-3810

2. E-3810

2.3.2 Depositor-Supplied Synonyms

1. 1058137-23-7

2. E-3810

3. E-3810 Amine

4. E-3810 Free Base

5. Al-3810

6. Pp449xa4bh

7. 6-((7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-n-methyl-1-naphthamide

8. Chebi:65209

9. 6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-n-methylnaphthalene-1-carboxamide

10. Co-3810

11. S 80881

12. S-80881

13. 1-naphthalenecarboxamide, 6-((7-((1-aminocyclopropyl)methoxy)-6-methoxy-4-quinolinyl)oxy)-n-methyl-

14. 6-((7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-n-methylnaphthalene-1-carboxamide

15. 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-n-methyl-1-naphthamide

16. Chembl2180605

17. Lucitanib [inn]

18. 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-n-methylnaphthalene-1-carboxamide

19. Lucitanib [usan:inn]

20. Unii-pp449xa4bh

21. Lucitanib(e3810)

22. E-3810; Lucitanib

23. Lucitanib (usan/inn)

24. Lucitanib [usan]

25. Lucitanib [who-dd]

26. Schembl381394

27. Gtpl7649

28. Chembl2220486

29. E 3810;e3810;lucitanib

30. Dtxsid30147356

31. Amy24149

32. Bcp05747

33. Ex-a2052

34. Bdbm50399539

35. Nsc782762

36. Nsc800786

37. Zinc77024213

38. Bcp9000632

39. Cs-0782

40. Db11845

41. Nsc-782762

42. Nsc-800786

43. Sb16928

44. 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-n-methyl-1-naphthamide

45. Ncgc00378878-02

46. Ncgc00378878-03

47. Ac-35833

48. As-82279

49. Da-33429

50. Hy-15391

51. Ft-0704073

52. D11762

53. E-3810e-3810

54. Q27082198

55. 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxy-quinolin-4-yloxy)-n-methyl-1-naphthamide

56. 3zc

2.4 Create Date

2008-11-17

3 Chemical and Physical Properties

Molecular Formula	C₂₆H₂₅N₃O₄
Molecular Weight	443.5 g/mol
XLogP3	3.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	443.18450629 g/mol
Monoisotopic Mass	443.18450629 g/mol
Topological Polar Surface Area	95.7 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	686
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1