Lodoxamide Tromethamine

Synopsis, Chemistry

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Also known as: Schembl24175, Chembl1201175, Dtxsid20979825, Akos015894824

Molecular Formula

C₁₅H₁₇ClN₄O₉

Molecular Weight

432.77 g/mol

InChI Key

KUGJPYZIWCRREB-UHFFFAOYSA-N

1 2D Structure

Lodoxamide Tromethamine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-amino-2-(hydroxymethyl)propane-1,3-diol;2-[2-chloro-5-cyano-3-(oxaloamino)anilino]-2-oxoacetic acid

2.1.2 InChI

InChI=1S/C11H6ClN3O6.C4H11NO3/c12-7-5(14-8(16)10(18)19)1-4(3-13)2-6(7)15-9(17)11(20)21;5-4(1-6,2-7)3-8/h1-2H,(H,14,16)(H,15,17)(H,18,19)(H,20,21);6-8H,1-3,5H2

2.1.3 InChI Key

KUGJPYZIWCRREB-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1=C(C=C(C(=C1NC(=O)C(=O)O)Cl)NC(=O)C(=O)O)C#N.C(C(CO)(CO)N)O

2.2 Synonyms

2.2.1 Depositor-Supplied Synonyms

1. Schembl24175

2. Chembl1201175

3. Dtxsid20979825

4. Akos015894824

2.3 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₁₇ClN₄O₉
Molecular Weight	432.77 g/mol
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	7
Exact Mass	432.0684058 g/mol
Monoisotopic Mass	432.0684058 g/mol
Topological Polar Surface Area	243 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	543
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Alomide
PubMed Health	Lodoxamide (Into the eye)
Drug Classes	Ophthalmologic Agent
Drug Label	ALOMIDE (lodoxamide tromethamine ophthalmic solution) 0.1% is a sterile ophthalmic solution containing the mast cell stabilizer lodoxamide tromethamine for topical administration to the eyes. Lodoxamide tromethamine is a white, crystalline, water-s...
Active Ingredient	Lodoxamide tromethamine
Dosage Form	Solution/drops
Route	Ophthalmic
Strength	eq 0.1% base
Market Status	Prescription
Company	Alcon

2 of 2
Drug Name	Alomide
PubMed Health	Lodoxamide (Into the eye)
Drug Classes	Ophthalmologic Agent
Drug Label	ALOMIDE (lodoxamide tromethamine ophthalmic solution) 0.1% is a sterile ophthalmic solution containing the mast cell stabilizer lodoxamide tromethamine for topical administration to the eyes. Lodoxamide tromethamine is a white, crystalline, water-s...
Active Ingredient	Lodoxamide tromethamine
Dosage Form	Solution/drops
Route	Ophthalmic
Strength	eq 0.1% base
Market Status	Prescription
Company	Alcon