Bora CDMO Bora CDMO

X

Find Linuron manufacturers, exporters & distributors on PharmaCompass

PharmaCompass
API SUPPLIERS
API Suppliers

API Suppliers

0

US DMFs Filed

US DMFs Filed

0

CEP/COS Certifications

CEP/COS Certifications

0

JDMFs Filed

JDMFs Filed

0

Other Certificates

Other Certificates

0

Other Suppliers

Other Suppliers

0

API REF. PRICE (USD / KG)

0

INTERMEDIATES

0

DOSSIERS // FDF
USA (Orange Book)

USA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Uploaded Dossiers

Uploaded Dossiers

0

GLOBAL SALES (USD Million)

U.S. Medicaid

0

Annual Reports

0

EXCIPIENTS

0

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

0

USFDA Exclusivities

0

DIGITAL CONTENT

Blog #PharmaFlow

0

News

0

REF STANDARD

EDQM

0

USP

0

JP

0

Other Listed Suppliers

0

SERVICES

0

Linuron
Also known as: 330-55-2, 3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea, Methoxydiuron, Afalon, Cephalon, Aphalon
Molecular Formula
C9H10Cl2N2O2
Molecular Weight
249.09  g/mol
InChI Key
XKJMBINCVNINCA-UHFFFAOYSA-N
FDA UNII
01XP1SU59O

A selective pre- and post-emergence herbicide. (From Merck Index, 11th ed)
1 2D Structure

Linuron

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea
2.1.2 InChI
InChI=1S/C9H10Cl2N2O2/c1-13(15-2)9(14)12-6-3-4-7(10)8(11)5-6/h3-5H,1-2H3,(H,12,14)
2.1.3 InChI Key
XKJMBINCVNINCA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN(C(=O)NC1=CC(=C(C=C1)Cl)Cl)OC
2.2 Other Identifiers
2.2.1 UNII
01XP1SU59O
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Afalon

2.3.2 Depositor-Supplied Synonyms

1. 330-55-2

2. 3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea

3. Methoxydiuron

4. Afalon

5. Cephalon

6. Aphalon

7. Linurex

8. Garnitan

9. Lorox

10. Herbicide 326

11. Afalon Inuron

12. Linorox

13. Rotalin

14. Sarclex

15. Sinuron

16. Du Pont 326

17. Linex 4l

18. Laroks

19. N'-(3,4-dichlorophenyl)-n-methoxy-n-methylurea

20. Dupont Herbicide 326

21. Urea, N'-(3,4-dichlorophenyl)-n-methoxy-n-methyl-

22. Lorox Linuron Weed Killer

23. 1-methoxy-1-methyl-3-(3,4-dichlorophenyl)urea

24. Hoe 2810

25. Urea, 3-(3,4-dichlorophenyl)-1-methoxy-1-methyl-

26. 3-(3,4-dichlorophenyl)-1-methoxy-1-methyl-urea

27. N-(3,4-dichlorophenyl)-n'-methyl-n'-methoxyurea

28. 01xp1su59o

29. Chebi:6482

30. Linex

31. 1-(3,4-dichlorophenyl)3-methoxy-3-methyluree

32. 3-(3,4-dichloor-fenyl)-1-methoxy-1-methylureum

33. 3-(3,4-dichloro-fenil)-1-metossi-1-metil-urea

34. 3-(4,5-dichlorphenyl)-1-methoxy-1-methylharnstoff

35. N-(3,4-dwuchlorofenylo)n'-metoksy-n'-metylomocznik

36. Linuron 10 Microg/ml In Acetonitrile

37. 3-(3,4-dichlor-phenyl)-1-methoxy-1-methyl-harnstoff

38. Linuron 100 Microg/ml In Acetonitrile

39. Malurane

40. Profalon

41. Soilcid

42. Certroli-lin

43. Dsstox_cid_4163

44. Laroks [polish]

45. Du Pont Herbicide 326

46. Dsstox_rid_77311

47. Lorox Weed Killer

48. Dsstox_gsid_24163

49. Linuron (herbicide)

50. Caswell No. 528

51. Alfalon

52. Linuron Solution

53. Linuron [ansi:bsi:iso]

54. Cas-330-55-2

55. Linuron [iso]

56. Hsdb 1733

57. Hoe 002810

58. Hoe 02 810

59. Einecs 206-356-5

60. Epa Pesticide Chemical Code 035506

61. Brn 2128725

62. Unii-01xp1su59o

63. Norunil

64. Scarclex

65. Atlas Linuron

66. 1-(3,4-dichlorophenyl)3-methoxy-3-methyluree [french]

67. 3-(3,4-dichloor-fenyl)-1-methoxy-1-methylureum [dutch]

68. 3-(3,4-dicloro-fenil)-1-metossi-1-metil-urea [italian]

69. 3-(3,4-dichloro-fenil)-1-metossi-1-metil-urea [italian]

70. 3-(4,5-dichlorphenyl)-1-methoxy-1-methylharnstoff [german]

71. 3-(3,4-dichlor-phenyl)-1-methoxy-1-methyl-harnstoff [german]

72. Linuron [hsdb]

73. N-(3,4-dwuchlorofenylo)n'-metoksy-n'-metylomocznik [polish]

74. Linuron [mi]

75. 3-(3,4-dicloro-fenil)-1-metossi-1-metil-urea

76. Schembl56566

77. N-(3,4-dichlorophenyl)-n'-methoxy-n'-methylurea

78. Bidd:er0455

79. Chembl448213

80. Dtxsid2024163

81. Xkjmbincvninca-uhfffaoysa-

82. Zinc900693

83. Hy-b1866

84. Linuron 100 Microg/ml In Methanol

85. Tox21_201281

86. Tox21_300732

87. Linuron 100 Microg/ml In N-hexane

88. Stk664290

89. Akos015889915

90. Ncgc00160429-01

91. Ncgc00160429-02

92. Ncgc00160429-03

93. Ncgc00160429-04

94. Ncgc00160429-05

95. Ncgc00160429-06

96. Ncgc00254638-01

97. Ncgc00258833-01

98. Db-048328

99. Linuron, Pestanal(r), Analytical Standard

100. Cs-0013933

101. Ft-0603379

102. L0395

103. 330l552

104. A821586

105. N'-(3,4-dichlorophenyl)-n-methoxy-n-methyl Urea

106. Q421476

107. J-018993

108. Linuron Solution, 100 Mug/ml In Methanol, Pestanal(r), Analytical Standard

2.4 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 249.09 g/mol
Molecular Formula C9H10Cl2N2O2
XLogP33.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass248.0119330 g/mol
Monoisotopic Mass248.0119330 g/mol
Topological Polar Surface Area41.6 Ų
Heavy Atom Count15
Formal Charge0
Complexity228
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Herbicides

Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE. (See all compounds classified as Herbicides.)


4.2 Absorption, Distribution and Excretion

IN CHRONIC TOXICITY STUDIES ... LINURON ... CONTINUOUSLY FED TO RATS & DOGS FOR ... TWO YR AT DIETARY LEVELS ... FROM 25 TO 2500 PPM ... TOTAL ANILINE-CONTAINING RESIDUES IN BLOOD & ... (MUSCLE, FAT, LIVER, KIDNEY, SPLEEN) WERE A FEW TO 100 PPM. ... RESIDUES REPRESENTED ONLY MINUTE FRACTION OF ... HERBICIDE INGESTED BY ANIMALS.

Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 237


LINURON IS MOST READILY ABSORBED THROUGH THE ROOT SYSTEM; LESS SO THROUGH FOLIAGE & STEMS. HOWEVER, FOLIAR ABSORPTION ... IS SIGNIFICANTLY GREATER THAN THAT OF DIURON, MONURON, OR FENURON. ... TRANSLOCATION IS PRIMARILY UPWARD IN THE XYLEM.

Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983., p. 287


... RESIDUE DATA ... OBTAINED IN SHORT TERM ELIMINATION EXPERIMENTS ... . AMT OFRADIOACTIVITY WHICH PERSISTED IN BLOOD & DIFFERENT TISSUES AT END OF 72 HR ... PERIODS WERE NO MORE & USUALLY MUCH LESS THAN 1% OF DOSE APPLIED.

Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 237


4.3 Metabolism/Metabolites

... LINURON-INDUCIBLE ENZYME WAS OBTAINED FROM BACILLUS SPHAERICUS. THIS ACYLAMIDASE DEGRADED LINURON BY HYDROLYSIS OF AMIDE BOND WITH ... RELEASE OF CARBON DIOXIDE & N,O-DIMETHYL HYDROXYLAMINE. ... ENZYME WAS SPECIFIC FOR METHOXY-SUBSTITUTED PHENYLUREAS & DID NOT HYDROLYZE 1,1-DIMETHYL PHENYLUREAS ... .

Menzie, C. M. Metabolism of Pesticides, An Update. U.S. Department of the Interior, Fish, Wild-life Service, Special Scientific Report - Wildlife No. 184, Washington, DC: U.S. Government Printing Office, l974., p. 382


IN GREENHOUSE STUDIES, LINURON ENTERED CORN (ZEA MAYS L), SOYBEAN (GLYCINE MAX L) & CRABGRASS (DIGITARIA SANGUINALIS L) WITH ABSORBED WATER. DEMETHYL LINURON & 3,4-DICHLORO-ANILINE WERE FOUND IN TISSUES. ... SOME LINURON BOUND WITHIN PLANT ... .

Menzie, C. M. Metabolism of Pesticides, An Update. U.S. Department of the Interior, Fish, Wild-life Service, Special Scientific Report - Wildlife No. 184, Washington, DC: U.S. Government Printing Office, l974., p. 382


LINURON ... FED TO ALBINO RATS. URINE ... ANALYZED FOR METABOLITES /&/ N-(3,4-DICHLOROPHENYL)UREA, N-(3,4-DICHLOROPHENYL)-N'-METHYLUREA & 3,4-DICHLOROANILINE WERE FOUND FREE. N-(2-HYDROXY-4,5-DICHLOROPHENYL)-N'-METHYLUREA, N-(5-HYDROXY-3,4-DICHLOROPHENYL)UREA & 6-ACETAMIDO-2,3-DICHLOROPHENOL ... /WERE IDENTIFIED/ AS GLUCURONIDES OR SULFATES.

Menzie, C.M. Metabolism of Pesticides. U.S. Department of the Interior, Bureau of Sport Fisheries and Wildlife, Publication 127. Washington, DC: U.S. Government Printing Office, 1969., p. 340


In rats linuron is metabolized by demethoxylation followed by hydroxylation of the benzene ring. Major urinary metabolites are urea derivatives; no unchanged linuron could be demonstrated. Only trace amounts of 3,4-dichloroaniline were found. If metabolism to dichloroaniline is major pathway in humans, ... methemoglobinemia should be anticipated after toxic doses.

Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-331


For more Metabolism/Metabolites (Complete) data for LINURON (9 total), please visit the HSDB record page.


4.4 Mechanism of Action

Inhibits photosynthesis.

Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook. 2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987., p. A248/Aug 87


Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty
Post Enquiry
POST ENQUIRY