Lanolin

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

13 API Suppliers, 1 USDMF, 8 CEP/COS, 4 Listed Suppliers

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports

DOSSIERs // Finished Dosage Formulations

8 Dossiers, 6 Canada, 2 Listed Dossiers

MARKET PLACE

4 EXCIPIENTS

4 EXCIPIENTS

ANALYTICAL SOLUTION(s)

2 Other Ref. Standards

2 Other Ref. Standards

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: Stearyl palmitate, Octadecyl palmitate, Octadecyl hexadecanoate, 2598-99-4, Hexadecanoic acid, octadecyl ester, Palmitic acid stearyl ester

Molecular Formula

C₃₄H₆₈O₂

Molecular Weight

508.9 g/mol

InChI Key

BILPUZXRUDPOOF-UHFFFAOYSA-N

FDA UNII

214W90O2XZ

lanolin is a natural product found in Bombax ceiba with data available.

1 2D Structure

Lanolin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

octadecyl hexadecanoate

2.1.2 InChI

InChI=1S/C34H68O2/c1-3-5-7-9-11-13-15-17-18-19-21-23-25-27-29-31-33-36-34(35)32-30-28-26-24-22-20-16-14-12-10-8-6-4-2/h3-33H2,1-2H3

2.1.3 InChI Key

BILPUZXRUDPOOF-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC

2.2 Other Identifiers

2.2.1 UNII

214W90O2XZ

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Hexadecanoic Acid Octadecyl Ester

2. Octadecyl Hexadecanoate

3. Octadecyl Palmitate

4. Palmitic Acid Octadecyl Ester

5. Stearyl Palmitate

2.3.2 Depositor-Supplied Synonyms

1. Stearyl Palmitate

2. Octadecyl Palmitate

3. Octadecyl Hexadecanoate

4. 2598-99-4

5. Hexadecanoic Acid, Octadecyl Ester

6. Palmitic Acid Stearyl Ester

7. 100231-75-2

8. 8006-54-0

9. Octadecanyl Hexadecanoate

10. Palmitic Acid, Octadecyl Ester

11. 214w90o2xz

12. We(18:0/16:0)

13. Einecs 220-000-6

14. Unii-214w90o2xz

15. Wool Grease

16. Ai3-30713

17. Wool Wax

18. Einecs 309-376-3

19. Wool Wax;wool Grease

20. Stearyl Palmitate, >=99%

21. Schembl33919

22. Dtxsid0026048

23. Stearyl Palmitate [inci]

24. Chebi:84066

25. Caa59899

26. Palmitic Acid, Stearyl Ester

27. Lmfa07010049

28. Zinc60050365

29. Akos028115046

30. Ccg-269767

31. Db-046811

32. Ft-0634387

33. J-016213

34. Q27157447

2.4 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	C₃₄H₆₈O₂
Molecular Weight	508.9 g/mol
XLogP3	16.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	32
Exact Mass	508.52193141 g/mol
Monoisotopic Mass	508.52193141 g/mol
Topological Polar Surface Area	26.3 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	406
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Warning

Since certain individuals are allergic to this substance, it should not be used in ointments intended for use by sensitive persons.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1250

4.2 Minimum/Potential Fatal Human Dose

1= PRACTICALLY NONTOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) ABOVE 15 G/KG, MORE THAN 1 QT FOR 70 KG PERSON (150 LB).

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-152

4.3 Drug Indication

Used as a skin protectant, and to relieve dryness and irritation of the skin,. Helps prevent and treat diaper dermatitis.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Lanolin treats cracked, dry, irritated skin and minor burns. It prevents and treats sore nipples during breastfeeding,. Protects chafed skin or minor skin irritations due to various causes,.

5.2 Mechanism of Action

Lanolin is an emollient. Emollients soften the skin by forming an occlusive oil film on the stratum corneum layer of the epithelium, thus decreasing the transepidermal water loss.