Find Ketamine Hydrochloride manufacturers, exporters & distributors on PharmaCompass

Ketamine

Ketamine

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

15 API Suppliers, 8 USDMF, 6 CEP/COS, 1 JDMF, 1 EU WC, 18 NDC API, 11 Listed Suppliers

DEVELOPMENTS

111 Drug(s) in Development

111 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports

DOSSIERs // Finished Dosage Formulations

61 Dossiers, 18 FDA Orange Book, 9 Europe, 9 Canada, 6 South Africa, 19 Listed Dossiers

DRUG PRODUCT COMPOSITION

INJECTABLE;INJECTION - EQ 100MG BASE/ML, INJECTABLE;INJECTION - EQ 10MG BASE/ML, INJECTABLE;INJECTION - EQ 50MG BASE/ML

INJECTABLE;INJECTION - EQ 100MG BASE/ML
INJECTABLE;INJECTION - EQ 10MG BASE/ML
INJECTABLE;INJECTION - EQ 50MG BASE/ML

RELATED EXCIPIENT COMPANIES

Suppliers, 3 Actylis, 2 Nanjing Well Pharmaceutical, 1 BASF, 1 Finar, 1 Kerry

EXCIPIENTS BY APPLICATIONS

4 Parenteral, 3 Solubilizers, 2 Film Formers & Plasticizers, 2 Topical, 1 Thickeners and Stabilizers, 1 Fillers, Diluents & Binders, 1 Coating Systems & Additives, 1 Emulsifying Agents, 1 Controlled & Modified Release

GLOBAL SALES INFORMATION

5 Finished Drug Prices

5 Finished Drug Prices

MARKET PLACE

11 APIs, 7 DOSSIERS // FDF

ANALYTICAL SOLUTION(s)

1 Analytical Solutions, 2 EDQM Standards, 2 USP Standards, 2 Other Ref. Standards

DIGITAL CONTENT

92 News

92 News

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

330

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: 1867-66-9, Vetalar, Ketaset, Ketalar, Ketamine hcl, Ketanest

Molecular Formula

C₁₃H₁₇Cl₂NO

Molecular Weight

274.18 g/mol

InChI Key

VCMGMSHEPQENPE-UHFFFAOYSA-N

FDA UNII

O18YUO0I83

A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.

1 2D Structure

Ketamine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one;hydrochloride

2.1.2 InChI

InChI=1S/C13H16ClNO.ClH/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14;/h2-3,6-7,15H,4-5,8-9H2,1H3;1H

2.1.3 InChI Key

VCMGMSHEPQENPE-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CNC1(CCCCC1=O)C2=CC=CC=C2Cl.Cl

2.2 Other Identifiers

2.2.1 UNII

O18YUO0I83

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone

2. Calipsol

3. Calypsol

4. Ci 581

5. Ci-581

6. Ci581

7. Kalipsol

8. Ketalar

9. Ketamine

10. Ketanest

11. Ketaset

2.3.2 Depositor-Supplied Synonyms

1. 1867-66-9

2. Vetalar

3. Ketaset

4. Ketalar

5. Ketamine Hcl

6. Ketanest

7. Ketolar

8. 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride

9. Cl 369

10. Cn-52,372-2

11. (+-)-ketamine Hydrochloride

12. Ci-581

13. Ketamine Hydrochloride Ciii

14. Ketamine (as Hydrochloride)

15. O18yuo0i83

16. Calipsol

17. Kalipsol

18. Ketavet

19. (+-)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride

20. Cl-369

21. Dea No. 7285

22. Cn-523722

23. 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one;hydrochloride

24. Cn-52372-2

25. Ketamine Chloride

26. Ketavet 100

27. Ketavet (veterinary)

28. Ci 581

29. Chebi:650657

30. Einecs 217-484-6

31. Unii-o18yuo0i83

32. Ketalar (tn)

33. Ketamini Hydrochloridum

34. Ketamine Hydrochloride [usan:usp:jan]

35. Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, Hydrochloride

36. Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, Hydrochloride, (+-)-

37. Ec 217-484-6

38. Chembl1714

39. Schembl26999

40. Dtxsid4040137

41. Ketamine Hydrochloride [mi]

42. 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one Hydrochloride

43. Bcp25943

44. Ketamine Hydrochloride (jp17/usp)

45. Ketamine Hydrochloride [jan]

46. (+/-)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride

47. Ketamine Hydrochloride [usan]

48. Nsc116131

49. (+/-)-ketamine Hydrochloride, Solid

50. Ketamine Hydrochloride [vandf]

51. Akos005287313

52. Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, Hydrochloride, (+-)-

53. Ketamine Hydrochloride [mart.]

54. Ab02117

55. Ketamine Hydrochloride [who-dd]

56. Ketamine Hydrochloride [who-ip]

57. Nsc-116131

58. Ketamine Hydrochloride [green Book]

59. Db-044614

60. Db-048467

61. Ketamine Hydrochloride [ep Impurity]

62. Ketamine Hydrochloride [orange Book]

63. Ketamine Hydrochloride [ep Monograph]

64. Ketamine Hydrochloride Ciii [usp-rs]

65. Ketamine Hydrochloride [usp Monograph]

66. Ketamini Hydrochloridum [who-ip Latin]

67. C07843

68. D00711

69. 867k669

70. A813079

71. Q-201266

72. Q27105184

73. Ketamine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

74. 2-(2-chlorophenyl)-2-(methylamino)-1-cyclohexanone Hydrochloride

75. Ketamine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

76. Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, Hydrochloride (1:1)

77. Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, Hydrochloride, (+/-)-

78. Ketamine (+-)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanonehydrochloride

79. Ketamine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₃H₁₇Cl₂NO
Molecular Weight	274.18 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	273.0687196 g/mol
Monoisotopic Mass	273.0687196 g/mol
Topological Polar Surface Area	29.1 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	269
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Ketalar
Drug Label	Ketalar is a nonbarbiturate anesthetic chemically designated dl 2-(0-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. It is formulated as a slightly acid (pH 3.5-5.5) sterile solution for intravenous or intramuscular injection in concentrat...
Active Ingredient	Ketamine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml; eq 50mg base/ml; eq 100mg base/ml
Market Status	Prescription
Company	Par Sterile Products

2 of 4
Drug Name	Ketamine hydrochloride
PubMed Health	Ketamine (Injection)
Drug Label	Ketamine hydrochloride is a nonbarbiturate anesthetic chemically designated dl 2-(0-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. It is formulated as a slightly acid (pH 3.5-5.5) sterile solution for intravenous or intramuscular injectio...
Active Ingredient	Ketamine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml; eq 50mg base/ml; eq 100mg base/ml
Market Status	Prescription
Company	Hospira; Mylan Institutional; Eurohlth Intl

3 of 4
Drug Name	Ketalar
Drug Label	Ketalar is a nonbarbiturate anesthetic chemically designated dl 2-(0-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. It is formulated as a slightly acid (pH 3.5-5.5) sterile solution for intravenous or intramuscular injection in concentrat...
Active Ingredient	Ketamine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml; eq 50mg base/ml; eq 100mg base/ml
Market Status	Prescription
Company	Par Sterile Products

4 of 4
Drug Name	Ketamine hydrochloride
PubMed Health	Ketamine (Injection)
Drug Label	Ketamine hydrochloride is a nonbarbiturate anesthetic chemically designated dl 2-(0-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. It is formulated as a slightly acid (pH 3.5-5.5) sterile solution for intravenous or intramuscular injectio...
Active Ingredient	Ketamine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml; eq 50mg base/ml; eq 100mg base/ml
Market Status	Prescription
Company	Hospira; Mylan Institutional; Eurohlth Intl

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anesthetics, Dissociative

Intravenous anesthetics that induce a state of sedation, immobility, amnesia, and marked analgesia. Subjects may experience a strong feeling of dissociation from the environment. The condition produced is similar to NEUROLEPTANALGESIA, but is brought about by the administration of a single drug. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) (See all compounds classified as Anesthetics, Dissociative.)

Analgesics

Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)

Excitatory Amino Acid Antagonists

Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists. (See all compounds classified as Excitatory Amino Acid Antagonists.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

General Anesthetic [EPC]; General Anesthesia [PE]