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    Chemistry

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    Also known as: 3505-38-2, Carbinoxamine maleate salt, Lergefin, Clistin, Ciberon, Cliston
    Molecular Formula
    C20H23ClN2O5
    Molecular Weight
    406.9  g/mol
    InChI Key
    GVNWHCVWDRNXAZ-BTJKTKAUSA-N
    FDA UNII
    02O55696WH
    Carbinoxamine
    Carbinoxamine Maleate is an ethanolamine class of H1 antihistamines with mild antimuscarinic and sedative properties. Carbinoxamine diminishes the typical histaminergic effects on H1-receptors in bronchial smooth muscle, capillaries, and gastrointestinal smooth muscle, including vasodilation, bronchoconstriction, increased vascular permeability, pain, itching, and spasmodic contractions of gastrointestinal smooth muscle. Carbinoxamine maleate is used to provide symptomatic relieve of allergic symptoms.
    1 2D Structure

    Carbinoxamine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (Z)-but-2-enedioic acid;2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine
    2.1.2 InChI
    InChI=1S/C16H19ClN2O.C4H4O4/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-10,16H,11-12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
    2.1.3 InChI Key
    GVNWHCVWDRNXAZ-BTJKTKAUSA-N
    2.1.4 Canonical SMILES
    CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    02O55696WH
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Carbinoxamine

    2. Histex Ct

    3. Histex I-e

    4. Histex Pd

    2.3.2 Depositor-Supplied Synonyms

    1. 3505-38-2

    2. Carbinoxamine Maleate Salt

    3. Lergefin

    4. Clistin

    5. Ciberon

    6. Cliston

    7. P-carbinoxamine Maleate

    8. Allergefon Maleate

    9. Paracarbinoxamine Maleate

    10. Nsc-62362

    11. Chebi:31353

    12. 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine Maleate

    13. Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-n,n-dimethyl-, (z)-2-butenedioate (1:1)

    14. 02o55696wh

    15. 3505-38-2 (carbinoxamine Maleate)

    16. Hislosine

    17. Ziriton

    18. Histine Sirup

    19. Polistin T-caps

    20. 2-((4-chlorophenyl)(pyridin-2-yl)methoxy)-n,n-dimethylethan-1-amine Maleate

    21. Polistine T-caps

    22. Dsstox_cid_27805

    23. Dsstox_rid_82573

    24. Dsstox_gsid_47828

    25. Carbinoxamine Hydrogen Maleate

    26. Arbinoxa

    27. {2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]ethyl}dimethylamine Maleate

    28. Clistine Maleate

    29. Clistin-d

    30. Karbinal Er

    31. (z)-but-2-enedioic Acid;2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-n,n-dimethylethanamine

    32. Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-n,n-dimethyl-, (2z)-2-butenedioate (1:1)

    33. Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-n,n-dimethyl-, (2z)-2-butenedioate (1:1)

    34. Component Of Clistin-d

    35. Sr-01000736676

    36. Ncgc00166141-01

    37. Einecs 222-498-0

    38. Nsc 62362

    39. Clistin Maleate

    40. Unii-02o55696wh

    41. Carbinoxamine Maleate [usp:jan]

    42. Prestwick_238

    43. Arbinoxamine Maleate

    44. Clistin (tn)

    45. Karbinal Er (tn)

    46. 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-n,n-dimethylethanamine Maleate

    47. Carbinoxamine (maleate)

    48. Carbinoxaminemaleate

    49. 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine Bimaleate

    50. 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine Maleate (1:1)

    51. Cas-3505-38-2

    52. Schembl97703

    53. Spectrum1500161

    54. Chembl1200974

    55. Dtxsid0047828

    56. Hms502i21

    57. Hy-b1589a

    58. Carbinoxamine Maleate (jan/usp)

    59. Carbinoxamine Maleate [mi]

    60. Hms1570b03

    61. Hms1920i21

    62. Hms2091a04

    63. Hms2097b03

    64. Hms3259g22

    65. Hms3714b03

    66. Hms3885f18

    67. Pharmakon1600-01500161

    68. Carbinoxamine Maleate [jan]

    69. Bcp28449

    70. Nsc62362

    71. Tox21_112336

    72. Carbinoxamine Maleate [vandf]

    73. Ccg-40113

    74. Mfcd00050923

    75. Nsc756670

    76. S4696

    77. Carbinoxamine Maleate [mart.]

    78. Wln: Qv1u1vq -c &621

    79. Akos015962162

    80. Carbinoxamine Maleate [usp-rs]

    81. Carbinoxamine Maleate [who-dd]

    82. Tox21_112336_1

    83. Ac-5508

    84. Cs-8018

    85. Nc00602

    86. Nsc-756670

    87. Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-n,n-dimethyl-,(2z)-2-butenedioate (1:1)

    88. Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)-, Maleate (1:1)

    89. Ncgc00095302-01

    90. Ncgc00166141-06

    91. Bs-43784

    92. Carbinoxamine Maleate [orange Book]

    93. Carbinoxamine Maleate [usp Monograph]

    94. Carbinoxamine Maleate Salt, Analytical Standard

    95. D01336

    96. Ethanamine,n-dimethyl-, (z)-2-butenedioate (1:1)

    97. Sr-01000736676-2

    98. Sr-01000736676-3

    99. Q27114280

    100. 2-[p-chloro-.alpha.-[2-(dimethylamino)ethoxy]benzyl]pyridine Bimaleate

    101. 2-[p-chloro-.alpha.-[2-(dimethylamino)ethoxy]benzyl]pyridine Maleate

    102. Carbinoxamine Maleate, United States Pharmacopeia (usp) Reference Standard

    103. 2-(p-chloro-.alpha.-(2-(dimethylamino)ethoxy)benzyl)pyridine Maleate (1:1)

    104. 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-n,n-dimethylethanamine (2z)-but-2-enedioate

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 406.9 g/mol
    Molecular Formula C20H23ClN2O5
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count8
    Exact Mass406.1295495 g/mol
    Monoisotopic Mass406.1295495 g/mol
    Topological Polar Surface Area100 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity386
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameCarbinoxamine maleate
    Drug LabelCarbinoxamine maleate is a histamine-H1 receptor blocking agent.Each 5 mL (teaspoonful) of oral solution contains 4 mg carbinoxamine maleate and the following inactive ingredients: artificial bubble gum flavor, citric acid (anhydrous), glycerin, meth...
    Active IngredientCarbinoxamine maleate
    Dosage FormTablet; Solution
    Routeoral; Oral
    Strength4mg; 4mg/5ml
    Market StatusPrescription
    CompanyVintage Pharms; Cypress Pharm; Lynrose Labs; Mikart; Invagen Pharms

    2 of 4  
    Drug NameKarbinal er
    PubMed HealthCarbinoxamine (By mouth)
    Drug ClassesCold/Cough Agent, Respiratory Agent
    Drug LabelEach 5 mL of Karbinal ER Extended-release Oral Suspension contains carbinoxamine complexed with polistirex equivalent to 4 mg carbinoxamine maleate and the following inactive ingredients: citric acid anhydrous, strawberry-banana flavor, glycerin, hig...
    Active IngredientCarbinoxamine maleate
    Dosage FormSuspension, extended release
    RouteOral
    Strength4mg/5ml
    Market StatusPrescription
    CompanyTris Pharma

    3 of 4  
    Drug NameCarbinoxamine maleate
    Drug LabelCarbinoxamine maleate is a histamine-H1 receptor blocking agent.Each 5 mL (teaspoonful) of oral solution contains 4 mg carbinoxamine maleate and the following inactive ingredients: artificial bubble gum flavor, citric acid (anhydrous), glycerin, meth...
    Active IngredientCarbinoxamine maleate
    Dosage FormTablet; Solution
    Routeoral; Oral
    Strength4mg; 4mg/5ml
    Market StatusPrescription
    CompanyVintage Pharms; Cypress Pharm; Lynrose Labs; Mikart; Invagen Pharms

    4 of 4  
    Drug NameKarbinal er
    PubMed HealthCarbinoxamine (By mouth)
    Drug ClassesCold/Cough Agent, Respiratory Agent
    Drug LabelEach 5 mL of Karbinal ER Extended-release Oral Suspension contains carbinoxamine complexed with polistirex equivalent to 4 mg carbinoxamine maleate and the following inactive ingredients: citric acid anhydrous, strawberry-banana flavor, glycerin, hig...
    Active IngredientCarbinoxamine maleate
    Dosage FormSuspension, extended release
    RouteOral
    Strength4mg/5ml
    Market StatusPrescription
    CompanyTris Pharma

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Histamine-1 Receptor Antagonist [EPC]; Histamine H1 Receptor Antagonists [MoA]

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    21-Jan-2022
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    ABOUT THIS PAGE

    Looking for 3505-38-2 / Carbinoxamine API manufacturers, exporters & distributors?

    Carbinoxamine manufacturers, exporters & distributors 1

    54

    PharmaCompass offers a list of Carbinoxamine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Carbinoxamine manufacturer or Carbinoxamine supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Carbinoxamine manufacturer or Carbinoxamine supplier.

    PharmaCompass also assists you with knowing the Carbinoxamine API Price utilized in the formulation of products. Carbinoxamine API Price is not always fixed or binding as the Carbinoxamine Price is obtained through a variety of data sources. The Carbinoxamine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Carbinoxamine

    Synonyms

    3505-38-2, Carbinoxamine maleate salt, Lergefin, Clistin, Ciberon, Cliston

    Cas Number

    3505-38-2

    Unique Ingredient Identifier (UNII)

    02O55696WH

    About Carbinoxamine

    Carbinoxamine Maleate is an ethanolamine class of H1 antihistamines with mild antimuscarinic and sedative properties. Carbinoxamine diminishes the typical histaminergic effects on H1-receptors in bronchial smooth muscle, capillaries, and gastrointestinal smooth muscle, including vasodilation, bronchoconstriction, increased vascular permeability, pain, itching, and spasmodic contractions of gastrointestinal smooth muscle. Carbinoxamine maleate is used to provide symptomatic relieve of allergic symptoms.

    Karbinal ER Manufacturers

    A Karbinal ER manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Karbinal ER, including repackagers and relabelers. The FDA regulates Karbinal ER manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Karbinal ER API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Karbinal ER manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Karbinal ER Suppliers

    A Karbinal ER supplier is an individual or a company that provides Karbinal ER active pharmaceutical ingredient (API) or Karbinal ER finished formulations upon request. The Karbinal ER suppliers may include Karbinal ER API manufacturers, exporters, distributors and traders.

    click here to find a list of Karbinal ER suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Karbinal ER USDMF

    A Karbinal ER DMF (Drug Master File) is a document detailing the whole manufacturing process of Karbinal ER active pharmaceutical ingredient (API) in detail. Different forms of Karbinal ER DMFs exist exist since differing nations have different regulations, such as Karbinal ER USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Karbinal ER DMF submitted to regulatory agencies in the US is known as a USDMF. Karbinal ER USDMF includes data on Karbinal ER's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Karbinal ER USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Karbinal ER suppliers with USDMF on PharmaCompass.

    Karbinal ER WC

    A Karbinal ER written confirmation (Karbinal ER WC) is an official document issued by a regulatory agency to a Karbinal ER manufacturer, verifying that the manufacturing facility of a Karbinal ER active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Karbinal ER APIs or Karbinal ER finished pharmaceutical products to another nation, regulatory agencies frequently require a Karbinal ER WC (written confirmation) as part of the regulatory process.

    click here to find a list of Karbinal ER suppliers with Written Confirmation (WC) on PharmaCompass.

    Karbinal ER NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Karbinal ER as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Karbinal ER API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Karbinal ER as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Karbinal ER and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Karbinal ER NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Karbinal ER suppliers with NDC on PharmaCompass.

    Karbinal ER GMP

    Karbinal ER Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Karbinal ER GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Karbinal ER GMP manufacturer or Karbinal ER GMP API supplier for your needs.

    Karbinal ER CoA

    A Karbinal ER CoA (Certificate of Analysis) is a formal document that attests to Karbinal ER's compliance with Karbinal ER specifications and serves as a tool for batch-level quality control.

    Karbinal ER CoA mostly includes findings from lab analyses of a specific batch. For each Karbinal ER CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Karbinal ER may be tested according to a variety of international standards, such as European Pharmacopoeia (Karbinal ER EP), Karbinal ER JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Karbinal ER USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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