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Chemistry

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Also known as: Jdq443, Jdq-443, 2653994-08-0, Q3w0h3v1lq, Nvp-jdq-443, Jdq-443 [who-dd]
Molecular Formula
C29H28ClN7O
Molecular Weight
526.0  g/mol
InChI Key
AZUYLZMQTIKGSC-UHFFFAOYSA-N
FDA UNII
Q3W0H3V1LQ

JDQ443
KRAS G12C Inhibitor JDQ443 is an inhibitor of the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic activity. Upon administration, KRAS G12C inhibitor JDQ443 selectively targets the KRAS G12C mutant and inhibits KRAS G12C mutant-dependent signaling. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.
1 2D Structure

JDQ443

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[6-[4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one
2.1.2 InChI
InChI=1S/C29H28ClN7O/c1-5-24(38)36-14-29(15-36)10-20(11-29)37-17(3)25(26-21-13-31-33-22(21)8-16(2)27(26)30)28(34-37)18-6-7-23-19(9-18)12-32-35(23)4/h5-9,12-13,20H,1,10-11,14-15H2,2-4H3,(H,31,33)
2.1.3 InChI Key
AZUYLZMQTIKGSC-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC2=C(C=NN2)C(=C1Cl)C3=C(N(N=C3C4=CC5=C(C=C4)N(N=C5)C)C6CC7(C6)CN(C7)C(=O)C=C)C
2.2 Other Identifiers
2.2.1 UNII
Q3W0H3V1LQ
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Jdq443

2. Jdq-443

3. 2653994-08-0

4. Q3w0h3v1lq

5. Nvp-jdq-443

6. Jdq-443 [who-dd]

7. Schembl23533580

8. Gtpl11715

9. Jdq 443

10. Glxc-25533

11. Ex-a5693

12. Compound 5 [pmid: 35404998]

13. Example 1a [wo2021120890a1]

14. Cs-0226220

15. 1-[6-[4-(5-chloro-6-methyl-1h-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one

2.4 Create Date
2021-08-21
3 Chemical and Physical Properties
Molecular Weight 526.0 g/mol
Molecular Formula C29H28ClN7O
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass525.2043862 g/mol
Monoisotopic Mass525.2043862 g/mol
Topological Polar Surface Area84.6 Ų
Heavy Atom Count38
Formal Charge0
Complexity936
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for / JDQ443 API manufacturers, exporters & distributors?

JDQ443 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of JDQ443 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right JDQ443 manufacturer or JDQ443 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred JDQ443 manufacturer or JDQ443 supplier.

PharmaCompass also assists you with knowing the JDQ443 API Price utilized in the formulation of products. JDQ443 API Price is not always fixed or binding as the JDQ443 Price is obtained through a variety of data sources. The JDQ443 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

JDQ443

Synonyms

Jdq-443, 2653994-08-0, Q3w0h3v1lq, Nvp-jdq-443, Jdq-443 [who-dd], Schembl23533580

Unique Ingredient Identifier (UNII)

Q3W0H3V1LQ

About JDQ443

KRAS G12C Inhibitor JDQ443 is an inhibitor of the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic activity. Upon administration, KRAS G12C inhibitor JDQ443 selectively targets the KRAS G12C mutant and inhibits KRAS G12C mutant-dependent signaling. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.

JDQ443 Manufacturers

A JDQ443 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of JDQ443, including repackagers and relabelers. The FDA regulates JDQ443 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. JDQ443 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

JDQ443 Suppliers

A JDQ443 supplier is an individual or a company that provides JDQ443 active pharmaceutical ingredient (API) or JDQ443 finished formulations upon request. The JDQ443 suppliers may include JDQ443 API manufacturers, exporters, distributors and traders.

JDQ443 GMP

JDQ443 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of JDQ443 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right JDQ443 GMP manufacturer or JDQ443 GMP API supplier for your needs.

JDQ443 CoA

A JDQ443 CoA (Certificate of Analysis) is a formal document that attests to JDQ443's compliance with JDQ443 specifications and serves as a tool for batch-level quality control.

JDQ443 CoA mostly includes findings from lab analyses of a specific batch. For each JDQ443 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

JDQ443 may be tested according to a variety of international standards, such as European Pharmacopoeia (JDQ443 EP), JDQ443 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (JDQ443 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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