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    Also known as: 148849-67-6, Ivabradine hcl, Procoralan, Corlentor, Corlanor, Ivabradine (hydrochloride)
    Molecular Formula
    C27H37ClN2O5
    Molecular Weight
    505.0  g/mol
    InChI Key
    HLUKNZUABFFNQS-ZMBIFBSDSA-N
    FDA UNII
    TP19837BZK
    Ivabradine Hydrochloride
    A benzazepine derivative and selective HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS inhibitor that lowers the heart rate. It is used in the treatment of CHRONIC STABLE ANGINA in patients unable to take BETA-ADRENERGIC BLOCKERS, and in the treatment of HEART FAILURE.
    1 2D Structure

    Ivabradine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;hydrochloride
    2.1.2 InChI
    InChI=1S/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1
    2.1.3 InChI Key
    HLUKNZUABFFNQS-ZMBIFBSDSA-N
    2.1.4 Canonical SMILES
    CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CC3CC4=CC(=C(C=C34)OC)OC.Cl
    2.1.5 Isomeric SMILES
    CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)C[C@H]3CC4=CC(=C(C=C34)OC)OC.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    TP19837BZK
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 7,8-dimethoxy-3-(3-(((4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2h-benzazepin-2-one

    2. Corlanor

    3. Ivabradine

    4. S 16257

    5. S 16257 2

    6. S 16257-2

    7. S 162572

    8. S 16260 2

    9. S 16260-2

    10. S 162602

    11. S-16257

    12. S-16257-2

    13. S-16260-2

    14. S16257

    15. S162572

    16. S162602

    2.3.2 Depositor-Supplied Synonyms

    1. 148849-67-6

    2. Ivabradine Hcl

    3. Procoralan

    4. Corlentor

    5. Corlanor

    6. Ivabradine (hydrochloride)

    7. Tp19837bzk

    8. (s)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2h-benzo[d]azepin-2-one Hydrochloride

    9. Ivabradine Hydrochloride [usan]

    10. Chebi:85969

    11. Amg 998

    12. Amg-998

    13. S-16257-2

    14. 2h-3-benzazepin-2-one, 3-[3-[[[(7s)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, Hydrochloride (1:1)

    15. Ncgc00181343-01

    16. 148849-67-6 (hcl)

    17. (s)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1h-benzo[d]azepin-2(3h)-one Hydrochloride

    18. 3-[3-[[[(7s)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2h-3-benzazepin-2-one Hydrochloride

    19. Ivabradinehydrochloride

    20. Ivabradine Hcl (procoralan)

    21. S16257

    22. Unii-tp19837bzk

    23. Corlentor (tn)

    24. Corlanor (tn)

    25. 2h-3-benzazepin-2-one, 3-(3-((((7s)-3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, Hydrochloride (1:1)

    26. 3-(3-((((7s)-3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2h-3-benzazepin-2-one Hydrochloride

    27. Coralan (tn)

    28. Ivabrandine Hydrochloride

    29. Ivabradine Monohydrochloride

    30. Dsstox_cid_26913

    31. Dsstox_rid_82011

    32. Dsstox_gsid_46913

    33. Schembl23470

    34. Mls006010110

    35. Ivabradine Hydrochloride- Bio-x

    36. Chembl2145077

    37. Dtxsid2046913

    38. Hy-b0162a

    39. 3-[3-[[(7s)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1h-3-benzazepin-4-one;hydrochloride

    40. Bcp05218

    41. Tox21_112802

    42. Ac-543

    43. Ivabradine Hydrochloride (jan/usan)

    44. Ivabradine Hydrochloride [mi]

    45. Mfcd00929899

    46. S2086

    47. Ivabradine Hydrochloride [jan]

    48. Akos015849582

    49. Akos016002249

    50. Bcp9000798

    51. Ccg-269739

    52. Cs-1994

    53. Gs-3584

    54. Ivabradine Hydrochloride [who-dd]

    55. (7,8-dimethoxy 3-(3-(((1s)-(4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2h-benzazepin-2-one Hydrochloride

    56. (s)-3-(3-(((4,5-dimethoxy-1,2-dihydrocyclobutabenzen-1-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1h-benzo[d]azepin-2(3h)-one Hydrochloride

    57. Bi164596

    58. Smr004701246

    59. Ivabradine Hydrochloride [ema Epar]

    60. Ivabradine Hydrochloride, >=98% (hplc)

    61. Am20090729

    62. B1360

    63. Cas-148849-67-6

    64. I0847

    65. Ivabradine Hydrochloride [orange Book]

    66. D08095

    67. 974i008

    68. J-008523

    69. J-521616

    70. Q27158823

    71. (+)-s16257

    72. 2h-3-benzazepin-2-one, 3-(3-((((7s)-3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, Monohydrochloride

    73. 2h-3-benzazepin-2-one, 3-(3-(((3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, Monohydrochloride, (s)-

    74. 3-[3-({[(7s)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-2,3,4,5-tetrahydro-1h-3-benzazepin-2-one Hydrochloride

    75. 3-[3-[[(8s)-3,4-dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1h-3-benzazepin-4-one Hydrochloride

    76. 3-[3-[[(8s)-3,4-dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1h-3-benzazepin-4-one Hydrochloride3-[3-[[(8s)-3,4-dimethoxy-8-bicyclo[4.2.0]octa-1,3,

    77. 3-{3-[{[(7s)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2h-3-benzazepin-2-one Hydrochloride

    78. 3-{3-[{[(7s)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2h-3-benzazepin-2-one--hydrogen Chloride (1/1)

    79. N-{[(7s)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-3h-3-benzazepin-3-yl)-n-methylpropan-1-aminium Chloride

    2.4 Create Date
    2005-08-09
    3 Chemical and Physical Properties
    Molecular Weight 505.0 g/mol
    Molecular Formula C27H37ClN2O5
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count10
    Exact Mass504.2391000 g/mol
    Monoisotopic Mass504.2391000 g/mol
    Topological Polar Surface Area60.5 Ų
    Heavy Atom Count35
    Formal Charge0
    Complexity663
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Indication

    Symptomatic treatment of chronic stable angina pectoris Ivabradine is indicated for the symptomatic treatment of chronic stable angina pectoris in coronary artery disease adults with normal sinus rhythm and heart rate 70 bpm. Ivabradine is indicated:

    - in adults unable to tolerate or with a contra-indication to the use of beta-blockers

    or

    - in combination with beta-blockers in patients inadequately controlled with an optimal beta-blocker dose. Treatment of chronic heart failure Ivabradine is indicated in chronic heart failure NYHA II to IV class with systolic dysfunction, in patients in sinus rhythm and whose heart rate is 75 bpm, in combination with standard therapy including beta-blocker therapy or when beta-blocker therapy is contraindicated or not tolerated.

    * Symptomatic treatment of chronic stable angina pectoris:

    Ivabradine is indicated for the symptomatic treatment of chronic stable angina pectoris in coronary artery disease adults with normal sinus rhythm and heart rate 70 bpm. Ivabradine is indicated:

    - in adults unable to tolerate or with a contraindication to the use of beta-blockers

    - or in combination with beta-blockers in patients inadequately controlled with an optimal beta-blocker dose.

    * Treatment of chronic heart failure:

    Ivabradine is indicated in chronic heart failure NYHA II to IV class with systolic dysfunction, in patients in sinus rhythm and whose heart rate is 75 bpm, in combination with standard therapy including beta-blocker therapy or when beta-blocker therapy is contraindicated or not tolerated.

    Symptomatic treatment of chronic stable angina pectoris

    Ivabradine is indicated for the symptomatic treatment of chronic stable angina pectoris in coronary artery disease adults with normal sinus rhythm and heart rate 70 bpm. Ivabradine is indicated:

    - in adults unable to tolerate or with a contraindication to the use of beta-blockers

    - or in combination with beta-blockers in patients inadequately controlled with an optimal beta-blocker dose.

    Treatment of chronic heart failure

    Ivabradine is indicated in chronic heart failure NYHA II to IV class with systolic dysfunction, in patients in sinus rhythm and whose heart rate is 75 bpm, in combination with standard therapy including beta-blocker therapy or when beta-blocker therapy is contraindicated or not tolerated.

    * Symptomatic treatment of chronic stable angina pectoris:

    Ivabradine is indicated for the symptomatic treatment of chronic stable angina pectoris in coronary artery disease adults with normal sinus rhythm and heart rate 70 bpm.

    Ivabradine is indicated:

    - in adults unable to tolerate or with a contra-indication to the use of beta-blockers

    - or in combination with beta-blockers in patients inadequately controlled with an optimal beta-blocker dose.

    * Treatment of chronic heart failure:

    Ivabradine is indicated in chronic heart failure NYHA II to IV class with systolic dysfunction, in patients in sinus rhythm and whose heart rate is 75 bpm, in combination with standard therapy including beta-blocker therapy or when beta-blocker therapy is contraindicated or not tolerated. (see section 5. 1)

    Symptomatic treatment of chronic stable angina pectoris in coronary artery disease adults with normal sinus rhythm and heart rate 70 bpm. Ivabradine is indicated: - in adults unable to tolerate or with a contra-indication to the use of beta-blockers - or in combination with beta-blockers in patients inadequately controlled with an optimal beta-blocker dose. Treatment of chronic heart failure Ivabradine is indicated in chronic heart failure NYHA II to IV class with systolic dysfunction, in patients in sinus rhythm and whose heart rate is 75 bpm, in combination with standard therapy including beta-blocker therapy or when beta-blocker therapy is contraindicated or not tolerated.

    Treatment of angina pectoris, Treatment of chronic heart failure, Treatment of coronary artery disease

    Treatment of angina pectoris, Treatment of chronic heart failure, Treatment of coronary artery disease

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Cardiovascular Agents

    Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume. (See all compounds classified as Cardiovascular Agents.)

    5.2 ATC Code

    C01EB17

    C01EB17

    C01EB17

    C01EB17

    C01EB17

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    IVABRADINE HYDROCHLORIDE

    About the Company : In the dinamic pharmaceutical field, DEAFARMA is the reference point for primaries Pharmaceutical Laboratories for over twenty years, even in the national and international territo...

    In the dinamic pharmaceutical field, DEAFARMA is the reference point for primaries Pharmaceutical Laboratories for over twenty years, even in the national and international territory. DEAFARMA works with success in the pharmaceutical raw materials field through Agencies and professional relations with the most important European and Asiatic factories. Our partners are well known, reliable producers and all of them are operating in accordance with the latest GMP Rules. The APIs mentioned in the DEAFARMA catalogue are always supported by DMF and/or CEP.
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    09

    Lunan Pharmaceutical

    China
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    Lunan Pharmaceutical

    China
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    Ivabradine Hydrochloride

    About the Company : Lunan Pharmaceutical Group is an integrated pharmaceutical group setting production, scientific research and sale of traditional Chinese medicines, chemicals, biological products i...

    Lunan Pharmaceutical Group is an integrated pharmaceutical group setting production, scientific research and sale of traditional Chinese medicines, chemicals, biological products in one, a national innovative enterprise, China Torch Program key high-tech enterprise. The group is composed of seven subsidiary enterprises including Lunan Hope Pharmaceutical Co., Ltd., Lunan Better Pharmaceutical Co., Ltd., Shandong New Time Pharmaceutical Co., Ltd., Lunan New Time Bio-Tech Co., Ltd., etc. It has been awarded the Top 500 Chinese Large Enterprise Group Competitiveness and Top 100 Taxpayers in Shandong Province for consecutive years.
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    10

    Shenzhen Haorui

    China
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    Shenzhen Haorui

    China
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    Ivabradine Hydrochloride

    About the Company : Haorui, established in 1997, is a manufacturer and supplier of APIs, intermediates, veterinary and food additives. Meanwhile, it is assisting global pharmaceutical companies to get...

    Haorui, established in 1997, is a manufacturer and supplier of APIs, intermediates, veterinary and food additives. Meanwhile, it is assisting global pharmaceutical companies to get the domestic registration of their finished dosage for their international expansion. Our USFDA approved products Flumazenil, Granisetron HCl, Granisetron Base, Docetaxel Anhydrous, Irinotecan HCl, Dasatinib Monohydrate, Oxaliplatin and Temozolomide have been recognized by our customers globally. In addition, our Amisulpride API acquired CEP, UK GMP & USDMF.
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Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1703269800,"product":"19270 - IVABRADINE HYDROCHLORIDE (FORMA IV)","address":"CENTAUR HOUSE, SHANTI NAGAR,","city":"MUMBAI ,MAHARASHTRA","supplier":"URQUIMA S A","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"CENTAUR PHARMACEUTICALS PRIVATE LTD","customerCountry":"INDIA","quantity":"0.15","actualQuantity":"0.15","unit":"KGS","unitRateFc":"10500","totalValueFC":"1747.3","currency":"EURO","unitRateINR":"969675","date":"23-Dec-2023","totalValueINR":"145451.25","totalValueInUsd":"1747.3","indian_port":"Bombay Air","hs_no":"29337990","bill_no":"9381692","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"POL,IND.RIERA DE CALDES PALAU-SOLITA I PIEGAMANS 08184 BARCELONA Barcelona, , Spain Spain","customerAddress":"CENTAUR HOUSE, SHANTI NAGAR,"},{"dataSource":"API 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Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730917800,"product":"IVABRADINE HYDROCHLORIDE","address":"304,ATLANTA ARCADE,","city":"MUMBAI MAHARASHTRA","supplier":"ZHEJIANG LIAOYUAN PHARMACEUTICAL CO","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"MACLEODS PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"1.10","actualQuantity":"1.1","unit":"KGS","unitRateFc":"7000","totalValueFC":"7751.3","currency":"USD","unitRateINR":"594650","date":"07-Nov-2024","totalValueINR":"654115","totalValueInUsd":"7751.3","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"6538541","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":".,LTD. 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    10-Jan-2022
    30-Sep-2025
    KGS
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    Average Price (USD/KGS)

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    Europe

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    01

    ALFRED E TIEFENBACHER GmbH & Co KG

    Germany
    arrow
    AIChE Annual Meeting
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

    Contact Supplier Contact Supplier
    Flag Germany
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : EU Dossier Readiness-Q4 2020

    Registration Country : Germany

    IVABRADINE HYDROCHLORIDE; Carvedilol

    Brand Name :

    Dosage Form : Hard Capsule

    Dosage Strength : 5MG; 12.5MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : EU Dossier Readiness-Q4 2020

    Registration Country : Germany

    Tiefenbacher Compnay Banner

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    02

    ALFRED E TIEFENBACHER GmbH & Co KG

    Germany
    arrow
    AIChE Annual Meeting
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

    Contact Supplier Contact Supplier
    Flag Germany
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : EU Dossier Readiness-Q4 2020

    Registration Country : Germany

    IVABRADINE HYDROCHLORIDE; Carvedilol

    Brand Name :

    Dosage Form : Hard Capsule

    Dosage Strength : 5MG; 25MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : EU Dossier Readiness-Q4 2020

    Registration Country : Germany

    Tiefenbacher Compnay Banner

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    03

    ALFRED E TIEFENBACHER GmbH & Co KG

    Germany
    arrow
    AIChE Annual Meeting
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

    Contact Supplier Contact Supplier
    Flag Germany
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : EU Dossier Readiness-Q4 2020

    Registration Country : Germany

    IVABRADINE HYDROCHLORIDE; Carvedilol

    Brand Name :

    Dosage Form : Hard Capsule

    Dosage Strength : 5MG; 6.25MG

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    ALFRED E TIEFENBACHER GmbH & Co KG

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    IVABRADINE HYDROCHLORIDE; Carvedilol

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    Dosage Form : Hard Capsule

    Dosage Strength : 7.5MG; 12.5MG

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    IVABRADINE HYDROCHLORIDE; Carvedilol

    Brand Name :

    Dosage Form : Hard Capsule

    Dosage Strength : 7.5MG; 25MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : EU Dossier Readiness-Q4 2020

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    ALFRED E TIEFENBACHER GmbH & Co KG

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    IVABRADINE HYDROCHLORIDE; Carvedilol

    Brand Name :

    Dosage Form : Hard Capsule

    Dosage Strength : 7.5MG; 6.25MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : EU Dossier Readiness-Q4 2020

    Registration Country : Germany

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    ALFRED E TIEFENBACHER GmbH & Co KG

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    Regulatory Info : Registered in EU

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    IVABRADINE HYDROCHLORIDE

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    Dosage Form : Film Coated Tablet

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    Regulatory Info : Registered in EU

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    ALFRED E TIEFENBACHER GmbH & Co KG

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    IVABRADINE HYDROCHLORIDE

    Brand Name :

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    Dosage Strength : 7.5MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : Registered in EU

    Registration Country : Germany

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    Ivabradine Hydrochloride

    Brand Name : Ivabradine Pharmathen

    Dosage Form : Film Coated Tablet

    Dosage Strength : 5MG

    Packaging :

    Approval Date : 2017-04-21

    Application Number : 81977

    Regulatory Info : Cancelled

    Registration Country : Spain

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    Regulatory Info : Cancelled

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    Ivabradine Hydrochloride

    Brand Name : Ivabradine Pharmathen

    Dosage Form : Film Coated Tablet

    Dosage Strength : 7.5MG

    Packaging :

    Approval Date : 2017-04-21

    Application Number : 81978

    Regulatory Info : Cancelled

    Registration Country : Spain

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    ABOUT THIS PAGE

    Looking for 148849-67-6 / Ivabradine Hydrochloride API manufacturers, exporters & distributors?

    Ivabradine Hydrochloride manufacturers, exporters & distributors 1

    30

    PharmaCompass offers a list of Ivabradine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ivabradine Hydrochloride manufacturer or Ivabradine Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ivabradine Hydrochloride manufacturer or Ivabradine Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Ivabradine Hydrochloride API Price utilized in the formulation of products. Ivabradine Hydrochloride API Price is not always fixed or binding as the Ivabradine Hydrochloride Price is obtained through a variety of data sources. The Ivabradine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Ivabradine Hydrochloride

    Synonyms

    148849-67-6, Ivabradine hcl, Procoralan, Corlentor, Corlanor, Ivabradine (hydrochloride)

    Cas Number

    148849-67-6

    Unique Ingredient Identifier (UNII)

    TP19837BZK

    About Ivabradine Hydrochloride

    A benzazepine derivative and selective HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS inhibitor that lowers the heart rate. It is used in the treatment of CHRONIC STABLE ANGINA in patients unable to take BETA-ADRENERGIC BLOCKERS, and in the treatment of HEART FAILURE.

    Ivabradine Hydrochloride Manufacturers

    A Ivabradine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ivabradine Hydrochloride, including repackagers and relabelers. The FDA regulates Ivabradine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ivabradine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Ivabradine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Ivabradine Hydrochloride Suppliers

    A Ivabradine Hydrochloride supplier is an individual or a company that provides Ivabradine Hydrochloride active pharmaceutical ingredient (API) or Ivabradine Hydrochloride finished formulations upon request. The Ivabradine Hydrochloride suppliers may include Ivabradine Hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Ivabradine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Ivabradine Hydrochloride USDMF

    A Ivabradine Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Ivabradine Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Ivabradine Hydrochloride DMFs exist exist since differing nations have different regulations, such as Ivabradine Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Ivabradine Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Ivabradine Hydrochloride USDMF includes data on Ivabradine Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ivabradine Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Ivabradine Hydrochloride suppliers with USDMF on PharmaCompass.

    Ivabradine Hydrochloride JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Ivabradine Hydrochloride Drug Master File in Japan (Ivabradine Hydrochloride JDMF) empowers Ivabradine Hydrochloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Ivabradine Hydrochloride JDMF during the approval evaluation for pharmaceutical products. At the time of Ivabradine Hydrochloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Ivabradine Hydrochloride suppliers with JDMF on PharmaCompass.

    Ivabradine Hydrochloride KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Ivabradine Hydrochloride Drug Master File in Korea (Ivabradine Hydrochloride KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Ivabradine Hydrochloride. The MFDS reviews the Ivabradine Hydrochloride KDMF as part of the drug registration process and uses the information provided in the Ivabradine Hydrochloride KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Ivabradine Hydrochloride KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Ivabradine Hydrochloride API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Ivabradine Hydrochloride suppliers with KDMF on PharmaCompass.

    Ivabradine Hydrochloride WC

    A Ivabradine Hydrochloride written confirmation (Ivabradine Hydrochloride WC) is an official document issued by a regulatory agency to a Ivabradine Hydrochloride manufacturer, verifying that the manufacturing facility of a Ivabradine Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Ivabradine Hydrochloride APIs or Ivabradine Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Ivabradine Hydrochloride WC (written confirmation) as part of the regulatory process.

    click here to find a list of Ivabradine Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

    Ivabradine Hydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Ivabradine Hydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Ivabradine Hydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Ivabradine Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Ivabradine Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Ivabradine Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Ivabradine Hydrochloride suppliers with NDC on PharmaCompass.

    Ivabradine Hydrochloride GMP

    Ivabradine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Ivabradine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ivabradine Hydrochloride GMP manufacturer or Ivabradine Hydrochloride GMP API supplier for your needs.

    Ivabradine Hydrochloride CoA

    A Ivabradine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Ivabradine Hydrochloride's compliance with Ivabradine Hydrochloride specifications and serves as a tool for batch-level quality control.

    Ivabradine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Ivabradine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Ivabradine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Ivabradine Hydrochloride EP), Ivabradine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ivabradine Hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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