Synopsis
Synopsis
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DRUG PRODUCT COMPOSITIONS0
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1. Orungal
2. R 51211
3. R-51211
4. R51211
5. Sporanox
1. Sporanox
2. 84625-61-6
3. Oriconazole
4. Itrizole (tn)
5. Sporanox (tn)
6. Itcz
7. Itrizole
8. Itraconazol
9. Orungal
10. Sporonox
11. Itraconazole (sporanox)
12. 2-butan-2-yl-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one
13. 873066-43-4
14. R-51211
15. Itraconazol [spanish]
16. Itraconazolum [latin]
17. Triasporin
18. Candistat
19. Canditral
20. Itralek
21. Sempera
22. Sporamelt
23. Traconal
24. Chembl22587
25. Itrac
26. Cis-itraconazole
27. Chebi:6076
28. Spherazole Cr
29. Spherazole Ir
30. R51211
31. Nsc-759239
32. Itz
33. Dsstox_cid_3180
34. Dsstox_rid_76908
35. (2r,4s)-itraconazole (mixture Of Diastereomers)
36. Dsstox_gsid_23180
37. Fungitraxx
38. Cladosal 100
39. 2-(butan-2-yl)-4-{4-[4-(4-{[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1h-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3h-1,2,4-triazol-3-one
40. 4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-sec-butyl-1,2,4-triazol-3-one
41. Cas-84625-61-6
42. 304nug5gf4
43. Intraconazole
44. Itraconazolo
45. Sporanox(tm)
46. Ncgc00018268-03
47. 3h-1,2,4-triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1h-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-
48. 4-(4-{4-[4-({[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1h-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}oxy)phenyl]piperazin-1-yl}phenyl)-2-(1-methylpropyl)-2,4-dihydro-3h-1,2,4-triazol-3-one
49. 84604-65-9
50. Itraconazole & Nyotran
51. R 51,211
52. Itraconazole [mi]
53. Itraconazole [inn]
54. Itraconazole [jan]
55. Itraconazole [inci]
56. Itraconazole [usan]
57. Itraconazole (jp17/usp)
58. Itraconazole [vandf]
59. Schembl23934
60. Itraconazole [mart.]
61. Mls006011958
62. Itraconazole [usp-rs]
63. Itraconazole [who-dd]
64. Amy922
65. Dtxsid3023180
66. Gtpl11426
67. Itraconazole [green Book]
68. Itraconazole [ep Impurity]
69. Itraconazole [orange Book]
70. Pharmakon1600-01505756
71. Itraconazole [ep Monograph]
72. 4-(4-(4-(4-((2-((1h-1,2,4-triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3h-1,2,4-triazol-3-one
73. Itraconazole [usp Monograph]
74. Tox21_110854
75. Ac-542
76. Bdbm50127138
77. Nsc759239
78. S2476
79. Akos015842738
80. Akos015961385
81. Tox21_110854_1
82. Ccg-270391
83. Db01167
84. Ks-1268
85. Ncgc00274068-01
86. Ncgc00274068-02
87. Ncgc00274068-07
88. 1-(butan-2-yl)-4-{4-[4-(4-{[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1h-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1h-1,2,4-triazol-5-one
89. 4-(4-(4-(4-(((2r,4s)-2-((1h-1,2,4-triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3h-1,2,4-triazol-3-one
90. Hy-17514
91. Smr001827898
92. Itraconazole & Nyotran(liposomal Nystatin)
93. Sbi-0206914.p001
94. Itraconazole (ema Epar: Veterinary)
95. Sw219756-1
96. Itraconazole 2.0 Mg/ml In Dimethyl Sulfoxide
97. D00350
98. Suba-itraconazole Component Itraconazole
99. Ab01274818-01
100. Ab01274818_02
101. Ab01274818_03
102. A933954
103. Itraconazole Component Of Suba-itraconazole
104. Q411229
105. Brd-a23067620-001-01-7
106. (+/-)-1-sec-butyl-4-(p-(4-(p-(((2r*,4s*)-2-(2,4-dichlorophenyl)-2-(1h-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-.delta.(sup 2)-1,2,4-triazolin-5-one
107. 3h-1,2,4-triazol-3-one, 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1h-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-pipera-zinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)
108. 4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1h-1,2,4-triazole-1-ylmethyl)-1,3-dioxolane-4-yl]methoxy]phenyl]piperazino]phenyl]-2-(1-methylpropyl)-4h-1,2,4-triazole-3(2h)-one
| Molecular Weight | 705.6 g/mol |
|---|---|
| Molecular Formula | C35H38Cl2N8O4 |
| XLogP3 | 5.7 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 11 |
| Exact Mass | 704.2393071 g/mol |
| Monoisotopic Mass | 704.2393071 g/mol |
| Topological Polar Surface Area | 101 Ų |
| Heavy Atom Count | 49 |
| Formal Charge | 0 |
| Complexity | 1120 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
| 1 of 4 | |
|---|---|
| Drug Name | Itraconazole |
| PubMed Health | Itraconazole (By mouth) |
| Drug Classes | Antifungal |
| Drug Label | SPORANOX is the brand name for itraconazole, a synthetic triazole antifungal agent. Itraconazole is a 1:1:1:1 racemic mixture of four diastereomers (two enantiomeric pairs), each possessing three chiral centers. It may be represented by the followi... |
| Active Ingredient | Itraconazole |
| Dosage Form | Capsule |
| Route | Oral |
| Strength | 100mg |
| Market Status | Prescription |
| Company | Mylan Pharms; Sandoz |
| 2 of 4 | |
|---|---|
| Drug Name | Sporanox |
| PubMed Health | Itraconazole (By mouth) |
| Drug Classes | Antifungal |
| Drug Label | SPORANOX is the brand name for itraconazole, a synthetic triazole antifungal agent. Itraconazole is a 1:1:1:1 racemic mixture of four diastereomers (two enantiomeric pairs), each possessing three chiral centers. It may be represented by the followi... |
| Active Ingredient | Itraconazole |
| Dosage Form | Capsule; Solution |
| Route | oral; Oral |
| Strength | 10mg/ml; 100mg |
| Market Status | Prescription |
| Company | Janssen Pharms; Janssen Pharma |
| 3 of 4 | |
|---|---|
| Drug Name | Itraconazole |
| PubMed Health | Itraconazole (By mouth) |
| Drug Classes | Antifungal |
| Drug Label | SPORANOX is the brand name for itraconazole, a synthetic triazole antifungal agent. Itraconazole is a 1:1:1:1 racemic mixture of four diastereomers (two enantiomeric pairs), each possessing three chiral centers. It may be represented by the followi... |
| Active Ingredient | Itraconazole |
| Dosage Form | Capsule |
| Route | Oral |
| Strength | 100mg |
| Market Status | Prescription |
| Company | Mylan Pharms; Sandoz |
| 4 of 4 | |
|---|---|
| Drug Name | Sporanox |
| PubMed Health | Itraconazole (By mouth) |
| Drug Classes | Antifungal |
| Drug Label | SPORANOX is the brand name for itraconazole, a synthetic triazole antifungal agent. Itraconazole is a 1:1:1:1 racemic mixture of four diastereomers (two enantiomeric pairs), each possessing three chiral centers. It may be represented by the followi... |
| Active Ingredient | Itraconazole |
| Dosage Form | Capsule; Solution |
| Route | oral; Oral |
| Strength | 10mg/ml; 100mg |
| Market Status | Prescription |
| Company | Janssen Pharms; Janssen Pharma |
Antifungal Agents; Antiprotozoal Agents
National Library of Medicine's Medical Subject Headings online file (MeSH, 2009)
Itraconazole capsules are indicated for the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: Blastomycosis, pulmonary and extrapulmonary; Histoplasmosis, including chronic cavitary pulmonary disease and disseminated, non-meningeal histoplasmosis and Aspergillosis, pulmonary and extrapulmonary, in patients who are intolerant of or who are refractory to amphotericin B therapy. /Included in US product label/
US Natl Inst Health; DailyMed. Current Medication Information for Itraconazole (itraconazole) capsule (February 2010). Available from, as of September 27, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=16279
Itraconazole capsules are also indicated for the treatment of the following fungal infections in non-immunocompromised patients: Onychomycosis of the toenail, with or without fingernail involvement, due to dermatophytes (tinea unguium) and Onychomycosis of the fingernail due to dermatophytes (tinea unguium). /Included in US product label/
US Natl Inst Health; DailyMed. Current Medication Information for Itraconazole (itraconazole) capsule (February 2010). Available from, as of September 27, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=16279
/BOXED WARNING/ Congestive Heart Failure, Cardiac Effects: Itraconazole capsules should not be administered for the treatment of onychomycosis in patients with evidence of ventricular dysfunction such as congestive heart failure (CHF) or a history of CHF. If signs or symptoms of congestive heart failure occur during administration of itraconazole capsules, discontinue administration. When itraconazole was administered intravenously to dogs and healthy human volunteers, negative inotropic effects were seen.
US Natl Inst Health; DailyMed. Current Medication Information for Itraconazole (itraconazole) capsule (Updated: June 2014). Available from, as of April 24, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d343050e-00bb-440c-a24b-7cd18c97e184
/BOXED WARNING/ Drug Interactions: Coadministration of the following drugs are contraindicated with itraconazole capsules: methadone, disopyramide, dofetilide, dronedarone, quinidine, ergot alkaloids (such as dihydroergotamine, ergometrine (ergonovine), ergotamine, methylergometrine (methylergonovine)), irinotecan, lurasidone, oral midazolam, pimozide, triazolam, felodipine, nisoldipine, ranolazine, eplerenone, cisapride, lovastatin, simvastatin and, in subjects with renal or hepatic impairment, colchicine. Coadministration with itraconazole can cause elevated plasma concentrations of these drugs and may increase or prolong both the pharmacologic effects and/or adverse reactions to these drugs. For example, increased plasma concentrations of some of these drugs can lead to QT prolongation and ventricular tachyarrhythmias including occurrences of torsades de pointes, a potentially fatal arrhythmia.
US Natl Inst Health; DailyMed. Current Medication Information for Itraconazole (itraconazole) capsule (Updated: June 2014). Available from, as of April 24, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d343050e-00bb-440c-a24b-7cd18c97e184
Itraconazole is contraindicated in patients with known hypersensitivity to the drug or any ingredient in the formulation. Although information concerning cross-sensitivity between itraconazole and other triazole or imidazole antifungal agents is not available, the manufacturer states that itraconazole should be used with caution in individuals hypersensitive to other azoles.
American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 531
Adverse GI effects have been reported in about 1-11% of patients receiving IV or oral itraconazole for the treatment of systemic fungal infections or oropharyngeal or esophageal candidiasis or for empiric anti-fungal therapy. These adverse GI effects usually are transient and respond to symptomatic treatment without alteration o
