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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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API Suppliers

API Suppliers

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

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Listed Suppliers

Other Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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Others

FINISHED DOSAGE FORMULATIONS

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FDF Dossiers

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FDA Orange Book

FDA (Orange Book)

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Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

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US Patents

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US Exclusivities

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Health Canada Patents

API REF. PRICE (USD/KG)

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GLOBAL SALES INFORMATION

US Medicaid

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Chemistry

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Also known as: Gdc-0068, 1001264-89-6, Ipatasertib (gdc-0068), Rg7440, Rg-7440, Gdc0068
Molecular Formula
C24H32ClN5O2
Molecular Weight
458.0  g/mol
InChI Key
GRZXWCHAXNAUHY-NSISKUIASA-N
FDA UNII
524Y3IB4HQ

Ipatasertib
Ipatasertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Ipatasertib binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
1 2D Structure

Ipatasertib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one
2.1.2 InChI
InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
2.1.3 InChI Key
GRZXWCHAXNAUHY-NSISKUIASA-N
2.1.4 Canonical SMILES
CC1CC(C2=C1C(=NC=N2)N3CCN(CC3)C(=O)C(CNC(C)C)C4=CC=C(C=C4)Cl)O
2.1.5 Isomeric SMILES
C[C@@H]1C[C@H](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[C@H](CNC(C)C)C4=CC=C(C=C4)Cl)O
2.2 Other Identifiers
2.2.1 UNII
524Y3IB4HQ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(4-chlorophenyl)-1-(4-(7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta(d)pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one

2. Gdc-0068

3. Gdc0068

2.3.2 Depositor-Supplied Synonyms

1. Gdc-0068

2. 1001264-89-6

3. Ipatasertib (gdc-0068)

4. Rg7440

5. Rg-7440

6. Gdc0068

7. Gdc 0068

8. Gdc-0068 (rg7440)

9. 524y3ib4hq

10. (s)-2-(4-chlorophenyl)-1-(4-((5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one

11. Chembl2177390

12. Rg 7440

13. (2s)-2-(4-chlorophenyl)-1-(4-((5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta(d)pyrimidin-4-yl)piperazin-1-yl(-3-((propan-2-yl)amino)propan-1-one

14. (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-6,7-dihydro-7-hydroxy-5-methyl-5h-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone

15. (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

16. 1-propanone, 2-(4-chlorophenyl)-1-(4-((5r,7r)-6,7-dihydro-7-hydroxy-5-methyl-5h-cyclopentapyrimidin-4-yl)-1-piperazinyl)-3-((1-methylethyl)amino)-, (2s)-

17. (2s)-2-(4-chlorophenyl)-1-{4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl}-3-(propan-2-ylamino)propan-1-one

18. Ipatasertib [inn]

19. Ipatasertib [usan:inn]

20. Unii-524y3ib4hq

21. Mfcd22124514

22. 1-propanone, 2-(4-chlorophenyl)-1-[4-[(5r,7r)-6,7-dihydro-7-hydroxy-5-methyl-5h-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-, (2s)-

23. Gdc0068 Di-hcl

24. Ipatasertib (usan/inn)

25. Ipatasertib [usan]

26. Gdc-0068 Di-hcl

27. Ipatasertib; Gdc-0068

28. Rg-7440 Di-hcl

29. Ipatasertib [who-dd]

30. Schembl191659

31. Gtpl7887

32. Chebi:95089

33. Dtxsid101025595

34. Ex-a2077

35. Bdbm50398379

36. Nsc767898

37. Nsc781451

38. Nsc800986

39. Nsc832484

40. S2808

41. Zinc68250459

42. Akos025396463

43. Bcp9000712

44. Ccg-269312

45. Cs-0975

46. Db11743

47. Nsc-767898

48. Nsc-781451

49. Nsc-800986

50. Nsc-832484

51. Ncgc00346714-01

52. 2-(4-chlorophenyl)-1-(4-(7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta(d)pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one

53. Ac-28420

54. As-17027

55. Hy-15186

56. Bcp0726000195

57. J3.478.537f

58. D10641

59. Q27078088

60. (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[e]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

61. 0rf

2.4 Create Date
2008-05-19
3 Chemical and Physical Properties
Molecular Weight 458.0 g/mol
Molecular Formula C24H32ClN5O2
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass457.2244530 g/mol
Monoisotopic Mass457.2244530 g/mol
Topological Polar Surface Area81.6 Ų
Heavy Atom Count32
Formal Charge0
Complexity622
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of breast cancer , Treatment of prostate cancer


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)


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ABOUT THIS PAGE

Looking for 1001264-89-6 / Ipatasertib API manufacturers, exporters & distributors?

Ipatasertib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Ipatasertib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ipatasertib manufacturer or Ipatasertib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ipatasertib manufacturer or Ipatasertib supplier.

PharmaCompass also assists you with knowing the Ipatasertib API Price utilized in the formulation of products. Ipatasertib API Price is not always fixed or binding as the Ipatasertib Price is obtained through a variety of data sources. The Ipatasertib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Ipatasertib

Synonyms

Gdc-0068, 1001264-89-6, Ipatasertib (gdc-0068), Rg7440, Rg-7440, Gdc0068

Cas Number

1001264-89-6

Unique Ingredient Identifier (UNII)

524Y3IB4HQ

About Ipatasertib

Ipatasertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Ipatasertib binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Ipatasertib Manufacturers

A Ipatasertib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ipatasertib, including repackagers and relabelers. The FDA regulates Ipatasertib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ipatasertib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ipatasertib Suppliers

A Ipatasertib supplier is an individual or a company that provides Ipatasertib active pharmaceutical ingredient (API) or Ipatasertib finished formulations upon request. The Ipatasertib suppliers may include Ipatasertib API manufacturers, exporters, distributors and traders.

Ipatasertib GMP

Ipatasertib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ipatasertib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ipatasertib GMP manufacturer or Ipatasertib GMP API supplier for your needs.

Ipatasertib CoA

A Ipatasertib CoA (Certificate of Analysis) is a formal document that attests to Ipatasertib's compliance with Ipatasertib specifications and serves as a tool for batch-level quality control.

Ipatasertib CoA mostly includes findings from lab analyses of a specific batch. For each Ipatasertib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ipatasertib may be tested according to a variety of international standards, such as European Pharmacopoeia (Ipatasertib EP), Ipatasertib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ipatasertib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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