Iothalamate Meglumine

Synopsis, Chemistry

DOSSIERs // Finished Dosage Formulations

7 Dossiers, 6 FDA Orange Book, 1 Canada

DRUG PRODUCT COMPOSITION

INJECTABLE;INJECTION - 43%, INJECTABLE;INJECTION - 60%, INJECTABLE;INJECTION - 30%

INJECTABLE;INJECTION - 43%
INJECTABLE;INJECTION - 60%
INJECTABLE;INJECTION - 30%

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Also known as: 13087-53-1, Meglumine iotalamate, Conray, Meglumine iothalamate, Iotalamate meglumine, Xuw72gop7w

Molecular Formula

C₁₈H₂₆I₃N₃O₉

Molecular Weight

809.1 g/mol

InChI Key

VLHUSFYMPUDOEL-WZTVWXICSA-N

FDA UNII

XUW72GOP7W

A radiopaque medium used for urography, angiography, venography, and myelography. It is highly viscous and binds to plasma proteins.

1 2D Structure

Iothalamate Meglumine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-acetamido-2,4,6-triiodo-5-(methylcarbamoyl)benzoic acid;(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol

2.1.2 InChI

InChI=1S/C11H9I3N2O4.C7H17NO5/c1-3(17)16-9-7(13)4(10(18)15-2)6(12)5(8(9)14)11(19)20;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-2H3,(H,15,18)(H,16,17)(H,19,20);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

2.1.3 InChI Key

VLHUSFYMPUDOEL-WZTVWXICSA-N

2.1.4 Canonical SMILES

CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)C(=O)NC)I.CNCC(C(C(C(CO)O)O)O)O

2.1.5 Isomeric SMILES

CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)C(=O)NC)I.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

2.2 Other Identifiers

2.2.1 UNII

XUW72GOP7W

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Conray 60

2. Iotalamate Meglumine

3. Iotalamate, Meglumine

4. Iotalamate, Methylglucamine

5. Iothalamate, Meglumine

6. Iothalamate, Methylglucamine

7. Iothalamic Acid Meglumine

8. Iothalamic Acid Methylglucamine

9. Meglumine Iotalamate

10. Meglumine Iothalamate

11. Meglumine, Iotalamate

12. Meglumine, Iothalamate

13. Meglumine, Iothalamic Acid

14. Methylglucamine Iotalamate

15. Methylglucamine Iothalamate

16. Methylglucamine, Iothalamic Acid

2.3.2 Depositor-Supplied Synonyms

1. 13087-53-1

2. Meglumine Iotalamate

3. Conray

4. Meglumine Iothalamate

5. Iotalamate Meglumine

6. Xuw72gop7w

7. Iothalamate Meglumine [usp]

8. Meglumine Iotalamate Injection

9. 1-deoxy-1-(methylamino)-d-glucitol 3-(acetylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl]benzoate

10. 3-acetamido-2,4,6-triiodo-5-(methylcarbamoyl)benzoic Acid;(2r,3r,4r,5s)-6-(methylamino)hexane-1,2,3,4,5-pentol

11. 1-deoxy-1-(methylamino)-d-glucitol 5-acetamido-2,4,6-triiodo-n-methylisophthalamate (salt)

12. Iothalamate Meglumine (usp)

13. Conray 60

14. Conray Meglumin

15. Meglumine Conray

16. Methylglucamine Iotalamate

17. Cysto-conray

18. Methylglucamine Iothalamate

19. Cysto-conray Ii

20. 3-acetamido-2,4,6-triiodo-5-(methylcarbamoyl)benzoic Acid;6-(methylamino)hexane-1,2,3,4,5-pentol

21. Benzoic Acid, 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)-, Compd. With 1-deoxy-1-(methylamino)-d-glucitol (1:1)

22. Contrix 28

23. Conray 30

24. Conray 43

25. Meglumine Isothalamate

26. Conray Meglumine 282

27. Iothalamate Methylglucamine

28. Iotalamate De Methylglucamine

29. Iothalamate Methylglucamine Salt

30. Jotalamsaeure Methylglucaminesalz

31. 1-deoxy-1-(methylamino)-d-glucitol 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoate

32. Einecs 235-998-9

33. Conray (tn)

34. Iothalamic Acid N-methylgucamine Salt

35. Iotalamate De Methylglucamine [french]

36. Iotalamic Acid Meglumine

37. Jotalamsaeure Methylglucaminesalz [german]

38. Unii-xuw72gop7w

39. Meglumine Iothalamate [ban]

40. D-glucitol, 1-deoxy-1-(methylamino)-, 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoate (salt)

41. Meglumine Iotalamate (jp17)

42. Schembl180546

43. Chembl1201125

44. Chebi:31714

45. Dtxsid10926949

46. Iothalamate Meglumine [vandf]

47. Meglumine Iotalamate [mart.]

48. Iotalamate Meglumine [who-dd]

49. Isophthalamic Acid, 5-acetamido-2,4,6-triiodo-n-methyl-, Compd. With 1-deoxy-1-(methylamino)-d-glucitol (1:1)

50. Iothalamate Meglumine [orange Book]

51. Iothalamate Meglumine [usp Impurity]

52. D01999

53. Vascoray Component Iothalamate Meglumine

54. Iothalamate Meglumine Component Of Vascoray

55. Iothalamic Acid N-methylglucamine Salt [mi]

56. Q27294007

57. 5-acetamido-2,4,6-triiodo-n-methylisophthalamic Acid-methylglucamine

58. Benzoic Acid, 3-(acetylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl]-, Compd. With D-glucitol, 1-deoxy-1-(methylamino)- (1:1)

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₂₆I₃N₃O₉
Molecular Weight	809.1 g/mol
Hydrogen Bond Donor Count	9
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	9
Exact Mass	808.8803 g/mol
Monoisotopic Mass	808.8803 g/mol
Topological Polar Surface Area	209 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	555
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 8
Drug Name	Conray 30
Drug Label	Conray 30 is a sterile aqueous solution intended for use as a diagnostic radiopaque medium. Conray 30 contains 30% w/v iothalamate meglumine which is 1-deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6 triiodo-N-methylisophthalamate (salt), and has...
Active Ingredient	Iothalamate meglumine
Dosage Form	Injectable
Route	Injection
Strength	30%
Market Status	Prescription
Company	Mallinckrodt

2 of 8
Drug Name	Conray 43
Drug Label	Conray 43 is a sterile aqueous solution intended for use as a diagnostic radiopaque medium. Conray 43 contains 43% w/v iothalamate meglumine which is 1-deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6-triiodo-N-methylisophthalamate (salt), and has...
Active Ingredient	Iothalamate meglumine
Dosage Form	Injectable
Route	Injection
Strength	43%
Market Status	Prescription
Company	Mallinckrodt

3 of 8
Drug Name	Cysto-conray
Drug Label	Cysto-Conray II is a sterile aqueous solution intended for instillation as a diagnostic radiopaque medium. Cysto-Conray II contains 17.2% w/v iothalamate meglumine which is 1-Deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6-triiodo-N-methylisophtha...
Active Ingredient	Iothalamate meglumine
Dosage Form	Solution
Route	intravesical, ureteral
Strength	43%
Market Status	Prescription
Company	Mallinckrodt

4 of 8
Drug Name	Cysto-conray ii
Drug Label	Cysto-Conray II is a sterile aqueous solution intended for instillation as a diagnostic radiopaque medium. Cysto-Conray II contains 17.2% w/v iothalamate meglumine which is 1-Deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6-triiodo-N-methylisophtha...
Active Ingredient	Iothalamate meglumine
Dosage Form	Solution
Route	Intravesical
Strength	17.2%
Market Status	Prescription
Company	Mallinckrodt

5 of 8
Drug Name	Conray 30
Drug Label	Conray 30 is a sterile aqueous solution intended for use as a diagnostic radiopaque medium. Conray 30 contains 30% w/v iothalamate meglumine which is 1-deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6 triiodo-N-methylisophthalamate (salt), and has...
Active Ingredient	Iothalamate meglumine
Dosage Form	Injectable
Route	Injection
Strength	30%
Market Status	Prescription
Company	Mallinckrodt

6 of 8
Drug Name	Conray 43
Drug Label	Conray 43 is a sterile aqueous solution intended for use as a diagnostic radiopaque medium. Conray 43 contains 43% w/v iothalamate meglumine which is 1-deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6-triiodo-N-methylisophthalamate (salt), and has...
Active Ingredient	Iothalamate meglumine
Dosage Form	Injectable
Route	Injection
Strength	43%
Market Status	Prescription
Company	Mallinckrodt

7 of 8
Drug Name	Cysto-conray
Drug Label	Cysto-Conray II is a sterile aqueous solution intended for instillation as a diagnostic radiopaque medium. Cysto-Conray II contains 17.2% w/v iothalamate meglumine which is 1-Deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6-triiodo-N-methylisophtha...
Active Ingredient	Iothalamate meglumine
Dosage Form	Solution
Route	intravesical, ureteral
Strength	43%
Market Status	Prescription
Company	Mallinckrodt

8 of 8
Drug Name	Cysto-conray ii
Drug Label	Cysto-Conray II is a sterile aqueous solution intended for instillation as a diagnostic radiopaque medium. Cysto-Conray II contains 17.2% w/v iothalamate meglumine which is 1-Deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6-triiodo-N-methylisophtha...
Active Ingredient	Iothalamate meglumine
Dosage Form	Solution
Route	Intravesical
Strength	17.2%
Market Status	Prescription
Company	Mallinckrodt