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Also known as: 775351-61-6, Imeglimin (hydrochloride), Imeglimin hcl, Imeglimin monohydrochloride, Mn7p3p5byb, Emd 387008 hydrochloride
Molecular Formula
C6H14ClN5
Molecular Weight
191.66  g/mol
InChI Key
UXHLCYMTNMEXKZ-PGMHMLKASA-N
FDA UNII
MN7P3P5BYB

Imeglimin Hydrochloride
1 2D Structure

Imeglimin Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4R)-6-N,6-N,4-trimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine;hydrochloride
2.1.2 InChI
InChI=1S/C6H13N5.ClH/c1-4-8-5(7)10-6(9-4)11(2)3;/h4H,1-3H3,(H3,7,8,9,10);1H/t4-;/m1./s1
2.1.3 InChI Key
UXHLCYMTNMEXKZ-PGMHMLKASA-N
2.1.4 Canonical SMILES
CC1N=C(NC(=N1)N(C)C)N.Cl
2.1.5 Isomeric SMILES
C[C@@H]1N=C(NC(=N1)N(C)C)N.Cl
2.2 Other Identifiers
2.2.1 UNII
MN7P3P5BYB
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 775351-61-6

2. Imeglimin (hydrochloride)

3. Imeglimin Hcl

4. Imeglimin Monohydrochloride

5. Mn7p3p5byb

6. Emd 387008 Hydrochloride

7. Imeglimin Hydrochloride [jan]

8. Imeglimin Hydrochloride [who-dd]

9. Imeglimin Hydrochloride (jan)

10. (4r)-6-n,6-n,4-trimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine;hydrochloride

11. 1,3,5-triazine-2,4-diamine, 3,6-dihydro-n2,n2,6-trimethyl-, Hydrochloride (1:1), (6r)-

12. 2650481-44-8

13. R-imeglimin Hydrochloride

14. Unii-mn7p3p5byb

15. Schembl2157885

16. (r)-n2,n2,6-trimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine Hydrochloride

17. Bcp11078

18. Hy-14771a

19. Mfcd28167741

20. Akos037643759

21. As-35168

22. D11807

23. A914496

24. Emd 387008 Hydrochloride;emd387008 Hydrochloride;emd-387008 Hydrochloride

2.4 Create Date
2012-01-16
3 Chemical and Physical Properties
Molecular Weight 191.66 g/mol
Molecular Formula C6H14ClN5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass191.0937732 g/mol
Monoisotopic Mass191.0937732 g/mol
Topological Polar Surface Area66 Ų
Heavy Atom Count12
Formal Charge0
Complexity205
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

API Reference Price

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LTD","customerCountry":"JAPAN","quantity":"2449.78","actualQuantity":"2449.78","unit":"KGS","unitRateFc":"147.2","totalValueFC":"354963.4","currency":"USD","unitRateINR":12345.235519107837,"date":"07-May-2025","totalValueINR":"30243111.07","totalValueInUsd":"354963.4","indian_port":"Hyderabad ICD","hs_no":"29335990","bill_no":"1605865","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad ICD","supplierAddress":"7-2-A2, HETERO CORPORATE,, HYDERABAD-A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1747765800,"product":"IMEGLIMIN HYDROCHLORIDE","address":"7-2-A2, HETERO CORPORATE,","city":"HYDERABAD-A.P.","supplier":"HETERO DRUGS LIMITED","supplierCountry":"INDIA","foreign_port":"KOBE","customer":"SUMITOMO PHARMA CO LTD","customerCountry":"JAPAN","quantity":"3055.53","actualQuantity":"3055.53","unit":"KGS","unitRateFc":"147.2","totalValueFC":"447222.2","currency":"USD","unitRateINR":12470.380948640661,"date":"21-May-2025","totalValueINR":"38103623.1","totalValueInUsd":"447222.2","indian_port":"Hyderabad ICD","hs_no":"29335990","bill_no":"2027631","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad ICD","supplierAddress":"7-2-A2, HETERO CORPORATE,, HYDERABAD-A.P.","customerAddress":""}]
04-Feb-2022
21-May-2025
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Drugs in Development

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Details:

The financing will be used to monetize a portion of Poxel's future royalties and sales-based payments from Twymeeg (imeglimin) sales by Sumitomo Pharma in Japan.


Lead Product(s): Imeglimin Hydrochloride

Therapeutic Area: Endocrinology Brand Name: Twymeeg

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: OrbiMed Advisors

Deal Size: $50.0 million Upfront Cash: Undisclosed

Deal Type: Financing September 30, 2024

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01

Poxel

France
arrow
APS Symposium
Not Confirmed

Poxel

France
arrow
APS Symposium
Not Confirmed

Details : The financing will be used to monetize a portion of Poxel's future royalties and sales-based payments from Twymeeg (imeglimin) sales by Sumitomo Pharma in Japan.

Product Name : Twymeeg

Product Type : Other Small Molecule

Upfront Cash : Undisclosed

September 30, 2024

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Details:

TWYMEEG (imeglimin hydrochloride), enhances insulin action by inhibiting hepatic glucose output and improving insulin signalling in both liver and skeletal muscle, in type 2 diabetes patients.


Lead Product(s): Imeglimin Hydrochloride

Therapeutic Area: Endocrinology Brand Name: Twymeeg

Study Phase: Phase IVProduct Type: Other Small Molecule

Sponsor: Poxel

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable July 08, 2024

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02

APS Symposium
Not Confirmed
APS Symposium
Not Confirmed

Details : TWYMEEG (imeglimin hydrochloride), enhances insulin action by inhibiting hepatic glucose output and improving insulin signalling in both liver and skeletal muscle, in type 2 diabetes patients.

Product Name : Twymeeg

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

July 08, 2024

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Details:

The companies entered into a strategic partnership for the development and commercialization of Twymeeg (imeglimin hydrochloride) in Japan, China, South Korea, Taiwan and nine other Southeast Asian countries.


Lead Product(s): Imeglimin Hydrochloride

Therapeutic Area: Endocrinology Brand Name: Twymeeg

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Sumitomo Pharma

Deal Size: $299.0 million Upfront Cash: $42.0 million

Deal Type: Partnership June 23, 2021

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03

Poxel

France
arrow
APS Symposium
Not Confirmed

Poxel

France
arrow
APS Symposium
Not Confirmed

Details : The companies entered into a strategic partnership for the development and commercialization of Twymeeg (imeglimin hydrochloride) in Japan, China, South Korea, Taiwan and nine other Southeast Asian countries.

Product Name : Twymeeg

Product Type : Other Small Molecule

Upfront Cash : $42.0 million

June 23, 2021

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Details:

Metavant will return all rights to Imeglimin to Poxel, as well as all data, materials, and information, including FDA regulatory filings, related to the program. Metavant is not entitled to any payment from Poxel as part of the return of the program.


Lead Product(s): Imeglimin Hydrochloride

Therapeutic Area: Endocrinology Brand Name: Twymeeg

Study Phase: Phase IIProduct Type: Other Small Molecule

Sponsor: Metavant Sciences

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Termination January 14, 2021

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04

Poxel

France
arrow
APS Symposium
Not Confirmed

Poxel

France
arrow
APS Symposium
Not Confirmed

Details : Metavant will return all rights to Imeglimin to Poxel, as well as all data, materials, and information, including FDA regulatory filings, related to the program. Metavant is not entitled to any payment from Poxel as part of the return of the program.

Product Name : Twymeeg

Product Type : Other Small Molecule

Upfront Cash : Undisclosed

January 14, 2021

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Details:

Metavant has conducted a strategic review and has decided not to move forward with the development of Imeglimin. Metavant will actively explore options for a potential out-licensing of Imeglimin rights for a period of 60 day.


Lead Product(s): Imeglimin Hydrochloride

Therapeutic Area: Endocrinology Brand Name: Twymeeg

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Poxel

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable November 20, 2020

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05

APS Symposium
Not Confirmed
APS Symposium
Not Confirmed

Details : Metavant has conducted a strategic review and has decided not to move forward with the development of Imeglimin. Metavant will actively explore options for a potential out-licensing of Imeglimin rights for a period of 60 day.

Product Name : Twymeeg

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

November 20, 2020

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Details:

Phase 3 TIMES 2 and TIMES 3 trial results demonstrate that Imeglimin met its primary endpoints and objectives and was observed to exhibit a favorable safety and tolerability profile.


Lead Product(s): Imeglimin Hydrochloride

Therapeutic Area: Endocrinology Brand Name: Twymeeg

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable September 24, 2020

blank

06

Poxel

France
arrow
APS Symposium
Not Confirmed

Poxel

France
arrow
APS Symposium
Not Confirmed

Details : Phase 3 TIMES 2 and TIMES 3 trial results demonstrate that Imeglimin met its primary endpoints and objectives and was observed to exhibit a favorable safety and tolerability profile.

Product Name : Twymeeg

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

September 24, 2020

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Details:

Sumitomo Dainippon Pharma has submitted a Japanese New Drug Application (J-NDA) to the Pharmaceuticals and Medical Devices Agency (PMDA) to request approval for the manufacturing and marketing of Imeglimin for the treatment of type 2 diabetes.


Lead Product(s): Imeglimin Hydrochloride

Therapeutic Area: Endocrinology Brand Name: Twymeeg

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Sumitomo Pharma

Deal Size: $21.3 million Upfront Cash: Undisclosed

Deal Type: Agreement July 30, 2020

blank

07

Poxel

France
arrow
APS Symposium
Not Confirmed

Poxel

France
arrow
APS Symposium
Not Confirmed

Details : Sumitomo Dainippon Pharma has submitted a Japanese New Drug Application (J-NDA) to the Pharmaceuticals and Medical Devices Agency (PMDA) to request approval for the manufacturing and marketing of Imeglimin for the treatment of type 2 diabetes.

Product Name : Twymeeg

Product Type : Other Small Molecule

Upfront Cash : Undisclosed

July 30, 2020

blank

Details:

Two drug-drug interaction studies assessed the effect of repeated co-administration of commonly prescribed medications, metformin or sitagliptin (Januvia®; Merck & Co.), with Imeglimin.


Lead Product(s): Imeglimin Hydrochloride

Therapeutic Area: Endocrinology Brand Name: Twymeeg

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable April 20, 2020

blank

08

Poxel

France
arrow
APS Symposium
Not Confirmed

Poxel

France
arrow
APS Symposium
Not Confirmed

Details : Two drug-drug interaction studies assessed the effect of repeated co-administration of commonly prescribed medications, metformin or sitagliptin (Januvia®; Merck & Co.), with Imeglimin.

Product Name : Twymeeg

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

April 20, 2020

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ABOUT THIS PAGE

Looking for 2650481-44-8 / Imeglimin Hydrochloride API manufacturers, exporters & distributors?

Imeglimin Hydrochloride manufacturers, exporters & distributors 1

100

PharmaCompass offers a list of Imeglimin Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Imeglimin Hydrochloride manufacturer or Imeglimin Hydrochloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Imeglimin Hydrochloride manufacturer or Imeglimin Hydrochloride supplier.

PharmaCompass also assists you with knowing the Imeglimin Hydrochloride API Price utilized in the formulation of products. Imeglimin Hydrochloride API Price is not always fixed or binding as the Imeglimin Hydrochloride Price is obtained through a variety of data sources. The Imeglimin Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Imeglimin Hydrochloride

Synonyms

775351-61-6, Imeglimin (hydrochloride), Imeglimin hcl, Imeglimin monohydrochloride, Mn7p3p5byb, Emd 387008 hydrochloride

Cas Number

2650481-44-8

Unique Ingredient Identifier (UNII)

MN7P3P5BYB

Imeglimin Hydrochloride Manufacturers

A Imeglimin Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Imeglimin Hydrochloride, including repackagers and relabelers. The FDA regulates Imeglimin Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Imeglimin Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Imeglimin Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Imeglimin Hydrochloride Suppliers

A Imeglimin Hydrochloride supplier is an individual or a company that provides Imeglimin Hydrochloride active pharmaceutical ingredient (API) or Imeglimin Hydrochloride finished formulations upon request. The Imeglimin Hydrochloride suppliers may include Imeglimin Hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Imeglimin Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Imeglimin Hydrochloride USDMF

A Imeglimin Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Imeglimin Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Imeglimin Hydrochloride DMFs exist exist since differing nations have different regulations, such as Imeglimin Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Imeglimin Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Imeglimin Hydrochloride USDMF includes data on Imeglimin Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Imeglimin Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Imeglimin Hydrochloride suppliers with USDMF on PharmaCompass.

Imeglimin Hydrochloride NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Imeglimin Hydrochloride as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Imeglimin Hydrochloride API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Imeglimin Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Imeglimin Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Imeglimin Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Imeglimin Hydrochloride suppliers with NDC on PharmaCompass.

Imeglimin Hydrochloride GMP

Imeglimin Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Imeglimin Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Imeglimin Hydrochloride GMP manufacturer or Imeglimin Hydrochloride GMP API supplier for your needs.

Imeglimin Hydrochloride CoA

A Imeglimin Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Imeglimin Hydrochloride's compliance with Imeglimin Hydrochloride specifications and serves as a tool for batch-level quality control.

Imeglimin Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Imeglimin Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Imeglimin Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Imeglimin Hydrochloride EP), Imeglimin Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Imeglimin Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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