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Chemistry

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Also known as: 172152-36-2, Iy-81149, Noltec, Iy 81149, Ilaprazole [inn], Iy81149
Molecular Formula
C19H18N4O2S
Molecular Weight
366.4  g/mol
InChI Key
HRRXCXABAPSOCP-UHFFFAOYSA-N
FDA UNII
776Q6XX45J

Ilaprazole
Ilaprazole is a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. A weak base, ilaprazole accumulates in the acidic environment of the secretory canaliculus of the gastric parietal cell where it is converted to an active sulfenamide form that binds to cysteine sulfhydryl groups on the luminal aspect of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.
1 2D Structure

Ilaprazole

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-6-pyrrol-1-yl-1H-benzimidazole
2.1.2 InChI
InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22)
2.1.3 InChI Key
HRRXCXABAPSOCP-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C=CN=C1CS(=O)C2=NC3=C(N2)C=C(C=C3)N4C=CC=C4)OC
2.2 Other Identifiers
2.2.1 UNII
776Q6XX45J
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Iy 81149

2. Iy-81149

3. Iy81149

2.3.2 Depositor-Supplied Synonyms

1. 172152-36-2

2. Iy-81149

3. Noltec

4. Iy 81149

5. Ilaprazole [inn]

6. Iy81149

7. 2-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-6-pyrrol-1-yl-1h-benzimidazole

8. 2-(((4-methoxy-3-methylpyridin-2-yl)methyl)sulfinyl)-6-(1h-pyrrol-1-yl)-1h-benzo[d]imidazole

9. 776q6xx45j

10. 2-[(4-methoxy-3-methyl-pyridin-2-yl)methylsulfinyl]-5-pyrrol-1-yl-3h-benzoimidazole

11. Aldenon

12. 1h-benzimidazole,2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-5-(1h-pyrrol-1-yl)- (9ci)

13. 2-((rs)-((4-methoxy-3-methylpyridin-2-yl)methyl)sulfinyl)-5-(1h-pyrrol-1-yl)-1h-benzimidazole

14. Unii-776q6xx45j

15. Ilaprazole [mart.]

16. Ilaprazole [who-dd]

17. Schembl1179039

18. Chembl2106370

19. Gtpl10512

20. Dtxsid10870115

21. Chebi:135544

22. Amy42072

23. Bcp08220

24. Xga15236

25. Iy81149;iy 81149;ilaprazole

26. S3666

27. Akos025401705

28. Ccg-268243

29. Cs-6444

30. Db11964

31. 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1h-pyrrol-1-yl)-1h-benzimidazole

32. Iy 81149iy81149

33. Ac-24701

34. Bs-15650

35. Db-064841

36. Hy-101664

37. Ft-0704889

38. Q15051261

39. 2-[(4-methoxy-3-methyl-pyridin-2-yl)methylsulfinyl]-6-pyrrol-1-yl-1h-benzoimidazole

40. 2-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-5-pyrrol-1-yl-3h-benzoimidazole

41. 2-{[(4-methoxy-3-methylpyridin-2-yl)methyl]sulfinyl}-5-(1h-pyrrol-1-yl)-1h-benzimidazole

2.4 Create Date
2005-08-09
3 Chemical and Physical Properties
Molecular Weight 366.4 g/mol
Molecular Formula C19H18N4O2S
XLogP32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass366.11504700 g/mol
Monoisotopic Mass366.11504700 g/mol
Topological Polar Surface Area92 Ų
Heavy Atom Count26
Formal Charge0
Complexity502
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

API SUPPLIERS

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Metrochem API Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothMetrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

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Metrochem

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Zhejiang Hengkang Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothZhejiang Hengkang Pharm Group is a dynamic pharmaceutical entity, spanning drug research, large-scale production, and global marketing.

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Zhejiang Hengkang Pharmaceutical

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Shandong Loncom Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothShandong Loncom is an R&D-focused manufacturer of Anti-cancer APIs.

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Aspire Lifesciences Pvt Ltd

India

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Everest Organics

India

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Maithri Drugs

India

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SPC Pharm

South Korea

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SPC Pharm

South Korea

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Jiangsu Sinopep Allsino Biopharmac...

China

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Tianjin Hankang Pharmaceutical Bio...

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Guangzhou Tosun Pharmaceutical

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HL Genomics

South Korea
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HL Genomics

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Ilaprazole

Registrant Name : Dasan Pharmaceutical Co., Ltd.

Registration Date : 2019-11-14

Registration Number : 2243-10-ND

Manufacturer Name : HL Genomics Co., Ltd. @ Dasa...

Manufacturer Address : 1552 Bogaewonsam-ro, Wonsam-myeon, Cheoin-gu, Yongin-si, Gyeonggi-do @ 342 Deokamsan-...

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ILYANG PHARM CO LTD

South Korea
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ILYANG PHARM CO LTD

South Korea
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Ilaprazole

Registrant Name : Ilyang Pharmaceutical Co., Ltd.

Registration Date : 2008-05-29

Registration Number : 1336-1-ND

Manufacturer Name : Ilyang Pharmaceutical Co., L...

Manufacturer Address : 110 Hagal-ro, Giheung-gu, Yongin-si, Gyeonggi-do

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Polaris AI Pharma

South Korea
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Polaris AI Pharma

South Korea
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Ilaprazole

Registrant Name : Ilyang Pharmaceutical Co., Ltd.

Registration Date : 2016-11-24

Registration Number : 1336-3-ND

Manufacturer Name : Polaris AI Pharma Co., Ltd.

Manufacturer Address : 25 Balan Industrial Complex-ro, Hyangnam-eup, Hwaseong-si, Gyeonggi-do, 34 Block 10-1...

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SPC Pharm

South Korea
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SPC Pharm

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Ilaprazole

Registrant Name : Dasan Pharmaceutical Co., Ltd.

Registration Date : 2023-12-26

Registration Number : 2243-12-ND

Manufacturer Name : SPC Co., Ltd. @ Dasan Pharma...

Manufacturer Address : 386 Pyeongtaek Port Road, Poseung-eup, Pyeongtaek-si, Gyeonggi-do @ 342 Deokamsan-ro,...

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API Reference Price

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LABORATORIES","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"6955","totalValueFC":"7029.3","currency":"USD","unitRateINR":"587002","date":"27-Apr-2024","totalValueINR":"587002","totalValueInUsd":"7029.3","indian_port":"Hyderabad Air","hs_no":"29333990","bill_no":"3223514","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"14\/F, BUILDING-1, NINGBO R&D PARK,NO.999, YANGFAN RD. HI-TECH DISTRICT, NINGBO, CHINA China China","customerAddress":"H.NO. 8-2-337,BESIDE TV9 OFFICE"}]
02-Jan-2022
16-May-2025
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Looking for 172152-36-2 / Ilaprazole API manufacturers, exporters & distributors?

Ilaprazole manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Ilaprazole API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ilaprazole manufacturer or Ilaprazole supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ilaprazole manufacturer or Ilaprazole supplier.

PharmaCompass also assists you with knowing the Ilaprazole API Price utilized in the formulation of products. Ilaprazole API Price is not always fixed or binding as the Ilaprazole Price is obtained through a variety of data sources. The Ilaprazole Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Ilaprazole

Synonyms

172152-36-2, Iy-81149, Noltec, Iy 81149, Ilaprazole [inn], Iy81149

Cas Number

172152-36-2

Unique Ingredient Identifier (UNII)

776Q6XX45J

About Ilaprazole

Ilaprazole is a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. A weak base, ilaprazole accumulates in the acidic environment of the secretory canaliculus of the gastric parietal cell where it is converted to an active sulfenamide form that binds to cysteine sulfhydryl groups on the luminal aspect of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.

Ilaprazole Manufacturers

A Ilaprazole manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ilaprazole, including repackagers and relabelers. The FDA regulates Ilaprazole manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ilaprazole API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Ilaprazole manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Ilaprazole Suppliers

A Ilaprazole supplier is an individual or a company that provides Ilaprazole active pharmaceutical ingredient (API) or Ilaprazole finished formulations upon request. The Ilaprazole suppliers may include Ilaprazole API manufacturers, exporters, distributors and traders.

click here to find a list of Ilaprazole suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ilaprazole KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Ilaprazole Drug Master File in Korea (Ilaprazole KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Ilaprazole. The MFDS reviews the Ilaprazole KDMF as part of the drug registration process and uses the information provided in the Ilaprazole KDMF to evaluate the safety and efficacy of the drug.

After submitting a Ilaprazole KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Ilaprazole API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Ilaprazole suppliers with KDMF on PharmaCompass.

Ilaprazole GMP

Ilaprazole Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ilaprazole GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ilaprazole GMP manufacturer or Ilaprazole GMP API supplier for your needs.

Ilaprazole CoA

A Ilaprazole CoA (Certificate of Analysis) is a formal document that attests to Ilaprazole's compliance with Ilaprazole specifications and serves as a tool for batch-level quality control.

Ilaprazole CoA mostly includes findings from lab analyses of a specific batch. For each Ilaprazole CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ilaprazole may be tested according to a variety of international standards, such as European Pharmacopoeia (Ilaprazole EP), Ilaprazole JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ilaprazole USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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