Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

Contact Supplier

EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

DEVELOPMENTS

4 Drugs in Development

4 Drugs in Development

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

4DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

API REF. PRICE (USD/KG)

$ 0

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Regulatory FDF Prices

API/FDF Prices: Book a Demo to
explore the features and consider
upgrading later

MARKET PLACE

API

FDF

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 1421936-85-7, Iclepertin [inn], Bi-425809, M43zdu10dd, Unii-m43zdu10dd, Bi425809

Molecular Formula

C₂₀H₁₈F₆N₂O₅S

Molecular Weight

512.4 g/mol

InChI Key

MYHDQTVHHMSLEF-DDBGAENHSA-N

FDA UNII

M43ZDU10DD

ICLEPERTIN is a small molecule drug with a maximum clinical trial phase of III (across all indications) and has 3 investigational indications.

1 2D Structure

Iclepertin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[5-methylsulfonyl-2-[(2R)-1,1,1-trifluoropropan-2-yl]oxyphenyl]-[(1R,5R)-1-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-3-azabicyclo[3.1.0]hexan-3-yl]methanone

2.1.2 InChI

InChI=1S/C20H18F6N2O5S/c1-10(19(21,22)23)32-14-4-3-12(34(2,30)31)5-13(14)17(29)28-8-11-7-18(11,9-28)15-6-16(33-27-15)20(24,25)26/h3-6,10-11H,7-9H2,1-2H3/t10-,11+,18+/m1/s1

2.1.3 InChI Key

MYHDQTVHHMSLEF-DDBGAENHSA-N

2.2 Other Identifiers

2.2.1 UNII

M43ZDU10DD

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Bi 425809

2.3.2 Depositor-Supplied Synonyms

1. 1421936-85-7

2. Iclepertin [inn]

3. Bi-425809

4. M43zdu10dd

5. Unii-m43zdu10dd

6. Bi425809

7. Bi 425809

8. [5-methylsulfonyl-2-[(2r)-1,1,1-trifluoropropan-2-yl]oxyphenyl]-[(1r,5r)-1-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-3-azabicyclo[3.1.0]hexan-3-yl]methanone

9. Methanone, (5-(methylsulfonyl)-2-((1r)-2,2,2-trifluoro-1-methylethoxy)phenyl)((1r,5r)-1-(5-(trifluoromethyl)-3-isoxazolyl)-3-azabicyclo(3.1.0)hex-3-yl)-

10. [5-?(methylsulfonyl)?-?2-?[(1r)?-?2,?2,?2-?trifluoro-?1-?methylethoxy]?phenyl]?[(1r,?5r)?-?1-?[5-?(trifluoromethyl)?-?3-?isoxazolyl]?-?3-?azabicyclo[3.1.0]?hex-?3-?yl]?-methanone

11. Methanone, [5-(methylsulfonyl)-2-[(1r)-2,2,2-trifluoro-1-methylethoxy]phenyl][(1r,5r)-1-[5-(trifluoromethyl)-3-isoxazolyl]-3-azabicyclo[3.1.0]hex-3-yl]-

12. Iclepertin [usan]

13. Iclepertin (jan/usan/inn)

14. Chembl5314576

15. Schembl22621289

16. Gtpl12110

17. Myhdqtvhhmslef-ddbgaenhsa-n

18. Glxc-25863

19. Ex-a9180

20. Akos040755624

21. Ms-29509

22. Hy-138935

23. Cs-0173438

24. D12527

25. G18229

26. En300-33036645

27. Z5066614506

28. (1r,5r)-3-(5-methanesulfonyl-2-{[(2r)-1,1,1-trifluoropropan-2-yl]oxy}benzoyl)-1-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-3-azabicyclo[3.1.0]hexane

29. (5-(methylsulfonyl)-2-((r)-1,1,1-trifluoropropan-2-yloxy)phenyl)((1r,5r)-1-(5-(trifluoromethyl)isoxazol-3-yl)-3-azabicyclo[3.1.0]hexan-3-yl)methanone

30. [5-(methylsulfonyl)-2-[(1r)-2,2,2-trifluoro-1-methylethoxy]phenyl][(1r,5r)-1-[5-(trifluoromethyl)-3-isoxazolyl]-3-azabicyclo[3.1.0]hex-3-yl]-methanone

31. [5-(methylsulfonyl)-2-[(1r)-2,2,2-trifluoro-1-methylethoxy]phenyl][(1r,5r)-1-[5-(trifluoromethyl)-3-isoxazolyl]-3-azabicyclo[3.1.0]hex-3-yl]methanone

2.4 Create Date

2020-12-19

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₁₈F₆N₂O₅S
Molecular Weight	512.4 g/mol
XLogP3	3.5
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	5
Exact Mass	Da
Monoisotopic Mass	Da
Topological Polar Surface Area	98.1
Heavy Atom Count	34
Formal Charge	0
Complexity	907
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Treatment of schizophrenia

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Nootropic Agents

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. (See all compounds classified as Nootropic Agents.)

Drugs in Development