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Chemistry

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Also known as: 33125-97-2, Ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate, Ethnor, Absele, 15301-65-2, C14h16n2o2
Molecular Formula
C14H16N2O2
Molecular Weight
244.29  g/mol
InChI Key
NPUKDXXFDDZOKR-UHFFFAOYSA-N

Etomidate
Etomidate is an imidazole derivative with short-acting sedative, hypnotic, and general anesthetic properties. Etomidate appears to have gamma-aminobutyric acid (GABA) like effects, mediated through GABA-A receptor. The action enhances the inhibitory effect of GABA on the central nervous system by causing chloride channel opening events which leads to membrane hyperpolarization.
1 2D Structure

Etomidate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
ethyl 3-(1-phenylethyl)imidazole-4-carboxylate
2.1.2 InChI
InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3
2.1.3 InChI Key
NPUKDXXFDDZOKR-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCOC(=O)C1=CN=CN1C(C)C2=CC=CC=C2
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Absele

2. Ethnor

2.2.2 Depositor-Supplied Synonyms

1. 33125-97-2

2. Ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate

3. Ethnor

4. Absele

5. 15301-65-2

6. C14h16n2o2

7. Radenarcon

8. Amidate (pharmaceutical)

9. Mls000034952

10. 1h-imidazole-5-carboxylic Acid, 1-(1-phenylethyl)-, Ethyl Ester, (r)-

11. Smr000010931

12. Dsstox_cid_3033

13. 1h-imidazole-5-carboxylic Acid, 1-(1-phenylethyl)-, Ethyl Ester, (+-)-

14. Dsstox_rid_76841

15. Dsstox_gsid_23033

16. 1-(1-phenylethyl)-1h-imidazole-5-carboxylic Acid Ethyl Ester

17. Ethyl 3-(1-phenylethyl)imidazole-4-carboxylate

18. Sr-01000325781

19. Rac-etomidate

20. Ncgc00016817-01

21. Cas-33125-97-2

22. Cpd000010931

23. Opera_id_1830

24. Prestwick0_001041

25. Prestwick1_001041

26. Prestwick2_001041

27. (+)-ethyl 1-(.alpha.-methylbenzyl)imidazole-5-carboxylate

28. Schembl39485

29. Mls001240191

30. Mls006011948

31. Chembl23731

32. Spbio_002901

33. Chebi:91759

34. Imidazole-5-carboxylic Acid, 1-(.alpha.-methylbenzyl)-, Ethyl Ester, (r)-(+)-

35. Bdbm238149

36. Dtxsid101347652

37. Hms1571a04

38. Hms1612g10

39. Hms2093p17

40. Hms2235k14

41. Hms3259f15

42. Hms3369p19

43. Hms3371k15

44. Hms3393p18

45. Hms3428l14

46. Hms3654n15

47. Pharmakon1600-01505599

48. Bcp21365

49. Us9394290, Eto (etomidate)

50. Tox21_110628

51. Nsc759160

52. S1329

53. Akos000548952

54. Akos021628930

55. Tox21_110628_1

56. Ac-5898

57. Ccg-266910

58. Nc00657

59. Ncgc00025176-02

60. Ncgc00036076-03

61. Ds-14867

62. Sbi-0206822.p001

63. Db-015827

64. Cs-0081287

65. Ft-0630568

66. Sw197275-2

67. En300-50290

68. Ab00439988-11

69. Ab00439988_13

70. Ethyl 3-(1-phenylethyl)imidazole-4-carboxylate.

71. A821630

72. Ethyl1-(1-phenylethyl)-1h-imidazole-5-carboxylate

73. Sr-01000325781-1

74. Sr-01000325781-3

75. Sr-01000325781-5

76. Brd-a54880345-001-11-8

77. Q27163565

78. 3-(1-phenylethyl)-4-imidazolecarboxylic Acid Ethyl Ester

79. Z802671476

80. (-)-ethyl 1-(1-phenylethyl)-1h-imidazole- 5-carboxylate

81. (-)-ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate

82. Ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate, (+)-

83. R-(+) Ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate

84. 1-(.alpha.-methylbenzyl)-1h-imidazole-5-carboxylic Acid Ethyl Ester

85. (r)-(+)-1-(.alpha.-methylbenzyl)imidazole-5-carboxylic Acid Ethyl Ester

86. [r,(+)]-1-(alpha-methylbenzyl)-1h-imidazole-5-carboxylic Acid Ethyl Ester

87. 1h-imidazole-5-carboxylic Acid, 1-(.alpha.-methylbenzyl)-, Ethyl Ester, (+)-

88. R 16659 Pound>>r-16659 Pound>>r16659 Pound>>r 26490 Pound>>r-26490 Pound>>r26490

2.3 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 244.29 g/mol
Molecular Formula C14H16N2O2
XLogP33
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass244.121177757 g/mol
Monoisotopic Mass244.121177757 g/mol
Topological Polar Surface Area44.1 Ų
Heavy Atom Count18
Formal Charge0
Complexity277
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameAmidate
Drug LabelAmidate (Etomidate Injection, USP) is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0).It is intended for the induction of general anesthesia by intravenous injection.The...
Active IngredientEtomidate
Dosage FormInjectable
RouteInjection
Strength2mg/ml
Market StatusPrescription
CompanyHospira

2 of 4  
Drug NameEtomidate
Drug LabelEtomidate Injection, USP is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0).It is intended for the induction of general anesthesia by intravenous injection.The drug etom...
Active IngredientEtomidate
Dosage FormInjectable
RouteInjection
Strength2mg/ml
Market StatusPrescription
CompanyPar Sterile Products; Bedford; Emcure Pharms; Luitpold; Zydus Pharms Usa; Agila Speclts

3 of 4  
Drug NameAmidate
Drug LabelAmidate (Etomidate Injection, USP) is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0).It is intended for the induction of general anesthesia by intravenous injection.The...
Active IngredientEtomidate
Dosage FormInjectable
RouteInjection
Strength2mg/ml
Market StatusPrescription
CompanyHospira

4 of 4  
Drug NameEtomidate
Drug LabelEtomidate Injection, USP is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0).It is intended for the induction of general anesthesia by intravenous injection.The drug etom...
Active IngredientEtomidate
Dosage FormInjectable
RouteInjection
Strength2mg/ml
Market StatusPrescription
CompanyPar Sterile Products; Bedford; Emcure Pharms; Luitpold; Zydus Pharms Usa; Agila Speclts

5 Pharmacology and Biochemistry
5.1 FDA Pharmacological Classification
5.1.1 Pharmacological Classes
General Anesthetic [EPC]; General Anesthesia [PE]
5.2 ATC Code

N01AX07

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


N - Nervous system

N01 - Anesthetics

N01A - Anesthetics, general

N01AX - Other general anesthetics

N01AX07 - Etomidate


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28-Feb-2022
24-Apr-2025
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ABOUT THIS PAGE

Looking for 33125-97-2 / Etomidate API manufacturers, exporters & distributors?

Etomidate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Etomidate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Etomidate manufacturer or Etomidate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Etomidate manufacturer or Etomidate supplier.

PharmaCompass also assists you with knowing the Etomidate API Price utilized in the formulation of products. Etomidate API Price is not always fixed or binding as the Etomidate Price is obtained through a variety of data sources. The Etomidate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Etomidate

Synonyms

33125-97-2, Ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate, Ethnor, Absele, 15301-65-2, C14h16n2o2

Cas Number

33125-97-2

About Etomidate

Etomidate is an imidazole derivative with short-acting sedative, hypnotic, and general anesthetic properties. Etomidate appears to have gamma-aminobutyric acid (GABA) like effects, mediated through GABA-A receptor. The action enhances the inhibitory effect of GABA on the central nervous system by causing chloride channel opening events which leads to membrane hyperpolarization.

Hypnomidate Manufacturers

A Hypnomidate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Hypnomidate, including repackagers and relabelers. The FDA regulates Hypnomidate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Hypnomidate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Hypnomidate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Hypnomidate Suppliers

A Hypnomidate supplier is an individual or a company that provides Hypnomidate active pharmaceutical ingredient (API) or Hypnomidate finished formulations upon request. The Hypnomidate suppliers may include Hypnomidate API manufacturers, exporters, distributors and traders.

click here to find a list of Hypnomidate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Hypnomidate USDMF

A Hypnomidate DMF (Drug Master File) is a document detailing the whole manufacturing process of Hypnomidate active pharmaceutical ingredient (API) in detail. Different forms of Hypnomidate DMFs exist exist since differing nations have different regulations, such as Hypnomidate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Hypnomidate DMF submitted to regulatory agencies in the US is known as a USDMF. Hypnomidate USDMF includes data on Hypnomidate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Hypnomidate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Hypnomidate suppliers with USDMF on PharmaCompass.

Hypnomidate CEP

A Hypnomidate CEP of the European Pharmacopoeia monograph is often referred to as a Hypnomidate Certificate of Suitability (COS). The purpose of a Hypnomidate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Hypnomidate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Hypnomidate to their clients by showing that a Hypnomidate CEP has been issued for it. The manufacturer submits a Hypnomidate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Hypnomidate CEP holder for the record. Additionally, the data presented in the Hypnomidate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Hypnomidate DMF.

A Hypnomidate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Hypnomidate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Hypnomidate suppliers with CEP (COS) on PharmaCompass.

Hypnomidate WC

A Hypnomidate written confirmation (Hypnomidate WC) is an official document issued by a regulatory agency to a Hypnomidate manufacturer, verifying that the manufacturing facility of a Hypnomidate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Hypnomidate APIs or Hypnomidate finished pharmaceutical products to another nation, regulatory agencies frequently require a Hypnomidate WC (written confirmation) as part of the regulatory process.

click here to find a list of Hypnomidate suppliers with Written Confirmation (WC) on PharmaCompass.

Hypnomidate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Hypnomidate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Hypnomidate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Hypnomidate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Hypnomidate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Hypnomidate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Hypnomidate suppliers with NDC on PharmaCompass.

Hypnomidate GMP

Hypnomidate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Hypnomidate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Hypnomidate GMP manufacturer or Hypnomidate GMP API supplier for your needs.

Hypnomidate CoA

A Hypnomidate CoA (Certificate of Analysis) is a formal document that attests to Hypnomidate's compliance with Hypnomidate specifications and serves as a tool for batch-level quality control.

Hypnomidate CoA mostly includes findings from lab analyses of a specific batch. For each Hypnomidate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Hypnomidate may be tested according to a variety of international standards, such as European Pharmacopoeia (Hypnomidate EP), Hypnomidate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Hypnomidate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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