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    Chemistry

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    Also known as: Hyoscyamine sulfate, Schembl34273, Chembl1697729
    Molecular Formula
    C17H25NO7S
    Molecular Weight
    387.4  g/mol
    InChI Key
    VJFQPODMEGSXHC-BXSBZORQSA-N
    Hyoscyamine Sulfate
    The 3(S)-endo isomer of atropine.
    1 2D Structure

    Hyoscyamine Sulfate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2S)-3-hydroxy-2-phenylpropanoate;sulfuric acid
    2.1.2 InChI
    InChI=1S/C17H23NO3.H2O4S/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4/h2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4)/t13-,14+,15?,16-;/m1./s1
    2.1.3 InChI Key
    VJFQPODMEGSXHC-BXSBZORQSA-N
    2.1.4 Canonical SMILES
    CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.OS(=O)(=O)O
    2.1.5 Isomeric SMILES
    CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)[C@H](CO)C3=CC=CC=C3.OS(=O)(=O)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Anaspaz

    2. Atropine Sulfate, 3(s)-endo-isomer

    3. Atropine, 3(s)-endo-isomer

    4. Cytospaz

    5. Hyoscyamine

    6. Hyoscyamine Hydrobromide

    7. Hyoscyamine Hydrochloride

    8. Hyoscyamine Sulfate

    9. Hyoscyamine Sulfate Anhydrous

    2.2.2 Depositor-Supplied Synonyms

    1. Hyoscyamine Sulfate

    2. Schembl34273

    3. Chembl1697729

    2.3 Create Date
    2007-12-12
    3 Chemical and Physical Properties
    Molecular Weight 387.4 g/mol
    Molecular Formula C17H25NO7S
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count5
    Exact Mass387.13517331 g/mol
    Monoisotopic Mass387.13517331 g/mol
    Topological Polar Surface Area133 Ų
    Heavy Atom Count26
    Formal Charge0
    Complexity434
    Isotope Atom Count0
    Defined Atom Stereocenter Count3
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Adjuvants, Anesthesia

    Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage. (See all compounds classified as Adjuvants, Anesthesia.)

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

    Bronchodilator Agents

    Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

    Muscarinic Antagonists

    Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

    Mydriatics

    Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics. (See all compounds classified as Mydriatics.)

    Parasympatholytics

    Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

    API Reference Price

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LTD","supplierCountry":"INDIA","foreign_port":"BEIRUT","customer":"UNDISCLOSED","customerCountry":"LEBANON","quantity":"0.05","actualQuantity":"0.05","unit":"KGS","unitRateFc":"34000","totalValueFC":"1673.1","currency":"USD","unitRateINR":2850900,"date":"07-May-2025","totalValueINR":"142545","totalValueInUsd":"1673.1","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"1586649","productDescription":"API","marketType":"","country":"LEBANON","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"VENKATESH,MAHANT ROAD EXTN,, VILE PARLE[E],MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1690396200,"product":"HYOSCYAMINE SULFATE","address":"PLOT NO-51,MEENAKSHI BAMBOO,GACHIB","city":"HYDERABAD,TELANGANA","supplier":"XXANSXXHARXXUSAXXLC","supplierCountry":"CHINA","foreign_port":"N\/A","customer":"CRONUS PHARMA SPECIALITIES INDIA PRIVATE LTD","customerCountry":"INDIA","quantity":"0.05","actualQuantity":"50","unit":"GMS","unitRateFc":"38.8","totalValueFC":"1956.3","currency":"USD","unitRateINR":"3215.7","date":"27-Jul-2023","totalValueINR":"160786","totalValueInUsd":"1956.3","indian_port":"GMR HYDERABAD AVIATION-SEZ","hs_no":"29391900","bill_no":"1003827","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"PLOT NO-51,MEENAKSHI BAMBOO,GACHIB"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1747938600,"product":"HYOSCYAMINE SULFATE","address":"PLOT NO-51,MEENAKSHI BAMBOO,GACHIB","city":"HYDERABAD,TELANGANA","supplier":"TRANSO PHARM USA LLC","supplierCountry":"UNITED STATES","foreign_port":"BEIJING","customer":"CRONUS PHARMA SPECIALITIES INDIA PRIVATE LTD","customerCountry":"INDIA","quantity":"0.05","actualQuantity":"50","unit":"GMS","unitRateFc":"39","totalValueFC":"1977.4","currency":"USD","unitRateINR":"3369.6","date":"23-May-2025","totalValueINR":"168480","totalValueInUsd":"1977.4","indian_port":"GMR HYDERABAD AVIATION-SEZ","hs_no":"29214290","bill_no":"2234512","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"216 Hazeltine Circle Blue Bell, PA SDNF UNITED STATES","customerAddress":"PLOT NO-51,MEENAKSHI BAMBOO,GACHIB"}]
    09-Jul-2022
    23-May-2025
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    ABOUT THIS PAGE

    Looking for 6835-16-1 / Hyoscyamine Sulfate API manufacturers, exporters & distributors?

    Hyoscyamine Sulfate manufacturers, exporters & distributors 1

    57

    PharmaCompass offers a list of Hyoscyamine Sulfate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Hyoscyamine Sulfate manufacturer or Hyoscyamine Sulfate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Hyoscyamine Sulfate manufacturer or Hyoscyamine Sulfate supplier.

    PharmaCompass also assists you with knowing the Hyoscyamine Sulfate API Price utilized in the formulation of products. Hyoscyamine Sulfate API Price is not always fixed or binding as the Hyoscyamine Sulfate Price is obtained through a variety of data sources. The Hyoscyamine Sulfate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Hyoscyamine Sulfate

    Synonyms

    Schembl34273, Chembl1697729

    Cas Number

    6835-16-1

    About Hyoscyamine Sulfate

    The 3(S)-endo isomer of atropine.

    Hyospaz Manufacturers

    A Hyospaz manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Hyospaz, including repackagers and relabelers. The FDA regulates Hyospaz manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Hyospaz API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Hyospaz manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Hyospaz Suppliers

    A Hyospaz supplier is an individual or a company that provides Hyospaz active pharmaceutical ingredient (API) or Hyospaz finished formulations upon request. The Hyospaz suppliers may include Hyospaz API manufacturers, exporters, distributors and traders.

    click here to find a list of Hyospaz suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Hyospaz USDMF

    A Hyospaz DMF (Drug Master File) is a document detailing the whole manufacturing process of Hyospaz active pharmaceutical ingredient (API) in detail. Different forms of Hyospaz DMFs exist exist since differing nations have different regulations, such as Hyospaz USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Hyospaz DMF submitted to regulatory agencies in the US is known as a USDMF. Hyospaz USDMF includes data on Hyospaz's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Hyospaz USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Hyospaz suppliers with USDMF on PharmaCompass.

    Hyospaz JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Hyospaz Drug Master File in Japan (Hyospaz JDMF) empowers Hyospaz API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Hyospaz JDMF during the approval evaluation for pharmaceutical products. At the time of Hyospaz JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Hyospaz suppliers with JDMF on PharmaCompass.

    Hyospaz CEP

    A Hyospaz CEP of the European Pharmacopoeia monograph is often referred to as a Hyospaz Certificate of Suitability (COS). The purpose of a Hyospaz CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Hyospaz EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Hyospaz to their clients by showing that a Hyospaz CEP has been issued for it. The manufacturer submits a Hyospaz CEP (COS) as part of the market authorization procedure, and it takes on the role of a Hyospaz CEP holder for the record. Additionally, the data presented in the Hyospaz CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Hyospaz DMF.

    A Hyospaz CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Hyospaz CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Hyospaz suppliers with CEP (COS) on PharmaCompass.

    Hyospaz WC

    A Hyospaz written confirmation (Hyospaz WC) is an official document issued by a regulatory agency to a Hyospaz manufacturer, verifying that the manufacturing facility of a Hyospaz active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Hyospaz APIs or Hyospaz finished pharmaceutical products to another nation, regulatory agencies frequently require a Hyospaz WC (written confirmation) as part of the regulatory process.

    click here to find a list of Hyospaz suppliers with Written Confirmation (WC) on PharmaCompass.

    Hyospaz NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Hyospaz as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Hyospaz API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Hyospaz as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Hyospaz and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Hyospaz NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Hyospaz suppliers with NDC on PharmaCompass.

    Hyospaz GMP

    Hyospaz Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Hyospaz GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Hyospaz GMP manufacturer or Hyospaz GMP API supplier for your needs.

    Hyospaz CoA

    A Hyospaz CoA (Certificate of Analysis) is a formal document that attests to Hyospaz's compliance with Hyospaz specifications and serves as a tool for batch-level quality control.

    Hyospaz CoA mostly includes findings from lab analyses of a specific batch. For each Hyospaz CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Hyospaz may be tested according to a variety of international standards, such as European Pharmacopoeia (Hyospaz EP), Hyospaz JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Hyospaz USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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