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    Hydrocortisone Hemisuccinate Hydrate

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    Hydrocortisone Hemisuccinate Hydrate
    Also known as: 83784-20-7, Hydrocortisone hemisuccinate, Liu00z1z84, Cortisol 21-(hydrogen succinate) monohydrate, 4-[2-[(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid;hydrate, Unii-liu00z1z84
    Molecular Formula
    C25H36O9
    Molecular Weight
    480.5  g/mol
    InChI Key
    AFLWPAGYTPJSEY-CODXZCKSSA-N
    FDA UNII
    LIU00Z1Z84
    Hydrocortisone Hemisuccinate is the synthetic hemisuccinate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties. Hydrocortisone acetate initially binds to the cytoplasmic glucocorticoid receptor; then the receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes.
    1 2D Structure

    Hydrocortisone Hemisuccinate Hydrate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid;hydrate
    2.1.2 InChI
    InChI=1S/C25H34O8.H2O/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);1H2/t16-,17-,18-,22+,23-,24-,25-;/m0./s1
    2.1.3 InChI Key
    AFLWPAGYTPJSEY-CODXZCKSSA-N
    2.1.4 Canonical SMILES
    CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)COC(=O)CCC(=O)O)O)C)O.O
    2.1.5 Isomeric SMILES
    C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)COC(=O)CCC(=O)O)O)C)O.O
    2.2 Other Identifiers
    2.2.1 UNII
    LIU00Z1Z84
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. A-hyrocort

    2. Cortisol Hemisuccinate

    3. Cortisol Succinate

    4. Cortisol Succinate, Sodium Salt

    5. Cortisol-21-(hydrogen Succinate)

    6. Hydrocortisone 21-sodium Succinate

    7. Hydrocortisone Hemisuccinate

    8. Hydrocortisone Hemisuccinate Anhydrous

    9. Hydrocortisone Succinate

    10. Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11beta)-

    11. Solu-cortef

    12. Sopolcort H

    13. Sopolkort

    2.3.2 Depositor-Supplied Synonyms

    1. 83784-20-7

    2. Hydrocortisone Hemisuccinate

    3. Liu00z1z84

    4. Cortisol 21-(hydrogen Succinate) Monohydrate

    5. 4-[2-[(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic Acid;hydrate

    6. Unii-liu00z1z84

    7. Nsc-757049

    8. Hydrocortisone Hemisuccinate [usan:usp]

    9. Chembl3989663

    10. Schembl22527563

    11. Dtxsid80894227

    12. Hydrocortisone Hemisuccinate (usp)

    13. Akos015896574

    14. Nsc 757049

    15. Hydrocortisone Hemisuccinate [usp-rs]

    16. D04467

    17. Hydrocortisone Hydrogen Succinate [mart.]

    18. Hydrocortisone Hemisuccinate [usp Monograph]

    19. Q27283005

    20. 21-(3-carboxypropanoyl)-11beta,17-dihydroxypregn-4-ene-3,20-dione Monohydrate

    21. 4-[2-[(10r,11s,13s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic Acid

    22. Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11 Beta)-, Monohydrate

    23. Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11.beta.)-, Monohydrate

    24. Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11beta)-, Monohydrate

    25. Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, Hydrate (1:1), (11beta)-

    2.4 Create Date
    2005-08-09
    3 Chemical and Physical Properties
    Molecular Weight 480.5 g/mol
    Molecular Formula C25H36O9
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count7
    Exact Mass480.23593272 g/mol
    Monoisotopic Mass480.23593272 g/mol
    Topological Polar Surface Area139 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity908
    Isotope Atom Count0
    Defined Atom Stereocenter Count7
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents

    Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

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